Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kah-Leong Lim"'
Autor:
Chao‐Chieh Lin, Jin Yan, Meghan D Kapur, Kristi L Norris, Cheng‐Wei Hsieh, De Huang, Nicolas Vitale, Kah‐Leong Lim, Ziqiang Guan, Xiao‐Fan Wang, Jen‐Tsan Chi, Wei‐Yuan Yang, Tso‐Pang Yao
Publikováno v:
EMBO reports. 23
Autophagy has emerged as the prime machinery for implementing organelle quality control. In the context of mitophagy, the ubiquitin E3 ligase Parkin tags impaired mitochondria with ubiquitin to activate autophagic degradation. Although ubiquitination
Autor:
Mui Hoon Nai, Hoang-Dai Tran, Huck-Hui Ng, Chwee Teck Lim, Kah-Leong Lim, Haidun Yan, Koji Itahana, Menglan Zhang, Stephanie Wai Lin Lim, Qiang Yuan, Yoko Itahana, Giuseppe D'Agostino, Yong-hui Jiang, Alfred Xuyang Sun, Eng-King Tan, Danlei Wang, Hidayat Lokman, Owen J. L. Rackham, Weonjin Yu, Stuart A. Cook, Grace Lim, Ya Yin Chang, Masahiro Fukuda, Hyunsoo Shawn Je, Jiong Tang
Publikováno v:
Science. 366:1486-1492
Hyperexcitable neurons in brain organoids Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing f
Autor:
Tong Zhou, Naidi Yang, Lin Li, Qiong Wu, Kah-Leong Lim, Wei Huang, Yaqi Ding, Jiajia Xu, Qi Wang, Chenqi Xin, Ma Bo, Chengwu Zhang, Xiaomei Lu, Deqin Kong, Hang Zhang
Publikováno v:
NeuroMolecular Medicine. 22:56-67
Parkinson's disease (PD), the most common neurodegenerative movement disorder, is characterized by the progressive loss of dopaminergic neurons in substantia nigra. The underlying mechanisms of PD pathogenesis have not been fully illustrated and curr
Autor:
Fai Tsang, Katherine C. M. Chew, Yee Kit Tai, Tuck Wah Soong, Eugenia T. E. Hong, Kah-Leong Lim, A.B.M.A. Asad, Kai-Hsiang Chuang, Eng-Tat Ang, Bryce W.Q. Tan, Bing Han Chai, Chengwu Zhang
Publikováno v:
Neuromolecular Medicine
Exposure to divalent metals such as iron and manganese is thought to increase the risk for Parkinson’s disease (PD). Under normal circumstances, cellular iron and manganese uptake is regulated by the divalent metal transporter 1 (DMT1). Accordingly
Autor:
Kah-Leong Lim, Bin Xiao, Zhi Dong Zhou, Xiao Deng, Wei Zhou, Eng-King Tan, Wuan-Ting Saw, Grace Lim
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864:1308-1317
Parkin/PINK1-mediated mitophagy is implicated in the pathogenesis of Parkinson's disease (PD). Prior to elimination of damaged mitochondria, Parkin translocates to mitochondria and induces mitochondrial clustering. While the mechanism of PINK1-depend
Publikováno v:
Neuromolecular Medicine
Parkinson's disease (PD) is a prevalent neurodegenerative movement disorder that is characterized pathologically by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive rese
Autor:
Chee-Hoe Ng, Vered Shani, Xiaofang Wang, Leslie G. Nucifora, Wanli W. Smith, Kah-Leong Lim, Tianxia Li, Elaine Roby, Dong Wei, Ted M. Dawson, Yajuan Guo, Frederick C. Nucifora, Darren J. Moore, Christopher A. Ross, Simone Engelender, Olga Pletnikova, Akira Sawa, Nicolas Arbez, Juan C. Troncoso
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications
A common genetic form of Parkinson's disease (PD) is caused by mutations in LRRK2. We identify WSB1 as a LRRK2 interacting protein. WSB1 ubiquitinates LRRK2 through K27 and K29 linkage chains, leading to LRRK2 aggregation and neuronal protection in p
Autor:
Chee-Hoe Ng, Henry Basil Adeline, Chengwu Zhang, Eugenia T. E. Hong, Bing Han Chai, Kah-Leong Lim
Publikováno v:
Neurodegenerative Diseases. 16:304-316
Mutations of parkin are a prevalent genetic contributor to familial Parkinson's disease (PD). As a key regulator of protein and mitochondrial homeostasis, parkin plays a pivotal role in maintaining dopaminergic neuronal survival. However, whereas Dro
Defective mitophagy linked to dysfunction in the proteins Parkin and PTEN-induced putative kinase 1 (PINK1) is implicated in the pathogenesis of Parkinson's disease. Although the mechanism by which Parkin mediates mitophagy in a PINK1-dependent manne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2b2b38565d938d834001262cfca734
https://europepmc.org/articles/PMC5633131/
https://europepmc.org/articles/PMC5633131/
Autor:
Adeline H. Basil, Chee-Hoe Ng, Sharon Philomena O'Neill, Fengwei Yu, Royston Tan, Kah-Leong Lim, Kian-Leong Goh, Liting Hang, Xiao-Dong Zhang
Publikováno v:
Neurobiology of Aging.
Despite intensive research, the etiology of Parkinson's disease (PD) remains poorly understood and the disease remains incurable. However, compelling evidence gathered over decades of research strongly support a role for mitochondrial dysfunction in