Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anthony Possemato"'
Autor:
Matthew P. Stokes, Anthony Possemato, Randall K. Wetzel, Jeffrey Mitchell, Michael J. Comb, Julie Nardone, Kimberly Lee, Judit Villén, Joan MacNeill, Roberto D. Polakiewicz, Jon M. Kornhauser, Gregory Innocenti, John Rush, Ailan Guo, Klarisa Rikova, Yi Wang, Steven P. Gygi
Publikováno v:
Proceedings of the National Academy of Sciences. 105:692-697
A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why some tumors respond and others do not. The observation that many tumors express EGF receptor (EGFR), yet only a small subset with EGFR-activating mutation
Autor:
Peter Hornbeck, John Rush, Jing Zhou, Steven P. Gygi, Michael J. Comb, Jian Min Ren, Judit Villén, Albrecht Moritz, Yu Li, Kam Sprott, Ailan Guo, Anthony Possemato, Jon M. Kornhauser, Lewis C. Cantley, Yi Wang, Joan MacNeill
Publikováno v:
Science signaling. 3(136)
Receptor tyrosine kinases (RTKs) activate pathways mediated by serine-threonine kinases, such as the PI3K (phosphatidylinositol 3-kinase)-Akt pathway, the Ras-MAPK (mitogen-activated protein kinase)-RSK (ribosomal S6 kinase) pathway, and the mTOR (ma
Autor:
Jon M. Kornhauser, Joan MacNeill, Jin Yuan, Roberto D. Polakiewicz, Qingfu Zeng, John Rush, Anthony Possemato, Zhi-Ping Tan, Julie Nardone, Daiqiang Li, Herbert Haack, Xinmin Zhou, Jeffrey Mitchell, Michael J. Comb, Matthew P. Stokes, Bradley L. Smith, Jian Min Ren, Cynthia Reeves, Jian Yu, Laura Sullivan, Ting-Lei Gu, Corey E. Bakalarski, Ailan Guo, Klarisa Rikova, Kimberly Lee, Judit Villén, Yerong Hu, Randy Wetzel, Steven P. Gygi, Yu Li
Publikováno v:
Cell. 131(6)
SummaryDespite the success of tyrosine kinase-based cancer therapeutics, for most solid tumors the tyrosine kinases that drive disease remain unknown, limiting our ability to identify drug targets and predict response. Here we present the first large