Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Aleksey V. Matveyenko"'
Autor:
Adrian Vella, Giuseppe De Nicolao, John G. Jones, Marcello C. Laurenti, James C. Andrews, Robert A. Rizza, Chiara Dalla Man, Aleksey V. Matveyenko, Cristina Barosa, Claudio Cobelli, Kent R. Bailey, Ron T. Varghese
Publikováno v:
J Clin Endocrinol Metab
Objective Pulsatile insulin secretion is impaired in diseases such as type 2 diabetes that are characterized by insulin resistance. This has led to the suggestion that changes in insulin pulsatility directly impair insulin signaling. We sought to exa
Autor:
Peiyu Wang, Aleksey V. Matveyenko, Peter C. Butler, Scott E. Fraser, Madeline Rosenberger, Jason A. Junge, David Elashoff, Raymond C. Stevens, Tatyana Gurlo, Zhongying Wang, Kate L. White
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Type 2 diabetes is characterized by β and α cell dysfunction. We used phasor-FLIM (Fluorescence Lifetime Imaging Microscopy) to monitor oxidative phosphorylation and glycolysis in living islet cells before and after glucose stimulation. In healthy
Autor:
Anu Sharma, Chiara Dalla Man, James C. Andrews, Claudio Cobelli, Robert A. Rizza, Ron T. Varghese, Adrian Vella, Giuseppe De Nicolao, Aleksey V. Matveyenko, Nana Esi Kittah, Marcello C. Laurenti
Publikováno v:
Am J Physiol Endocrinol Metab
The characteristics of pulsatile insulin secretion are important determinants of type 2 diabetes pathophysiology, but they are understudied due to the difficulties in measuring pulsatile insulin secretion noninvasively. Deconvolution of either periph
Autor:
Ron T. Varghese, John Thomas Jones, Marcello C. Laurenti, Giuseppe De Nicolao, Robert A. Rizza, Aleksey V. Matveyenko, Cristina Barosa, Claudio Cobelli, Chiara Dalla Man, Adrian Vella
Publikováno v:
Diabetes. 69
Insulin is secreted into the portal vein in a pulsatile manner. Portal vein insulin concentrations directly and rapidly alter endogenous glucose production (EGP). Pulse frequency has been inversely correlated with hepatic insulin action in some, but
Autor:
Adrian Vella, Chiara Dalla Man, Marcello C. Laurenti, Aleksey V. Matveyenko, Giuseppe De Nicolao, James C. Andrews, Claudio Cobelli, Ron T. Varghese, Robert A. Rizza
Publikováno v:
JCI Insight
BACKGROUND: Metabolic disorders such as type 2 diabetes have been associated with a decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at rs7903146 in TCF7L2, previously associated with β cell dysfunction, would be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a60e999b93c34caf4976b62c7009b8
http://hdl.handle.net/11577/3391360
http://hdl.handle.net/11577/3391360
Autor:
Katherine L O'Grady, Brianne S Thicke, João F. Passos, Jennifer L. Rowsey, Olga P. Bondar, Aleksey V. Matveyenko, Brittany A. Eckhardt, David G. Monroe, Anthony B. Lagnado, Ravinder J. Singh, Sundeep Khosla, Daniel G. Fraser, Adrian Vella, Jolaine M. Hines, Joshua N. Farr, Andrew R. Thoreson, Kuntol Rakshit
Publikováno v:
JCI Insight
The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part, from poor bone quality. Advanced glycation endproducts (AGEs) and
Autor:
Sajan Jiv Singh Nagpal, Shilpa Sannapaneni, Aleksey V. Matveyenko, Ayush Sharma, Pruthvi R. Velamala, Shounak Majumder, Harika Kandlakunta, Suresh T. Chari
Publikováno v:
American Journal of Gastroenterology. 113:S26-S28
Publikováno v:
Metabolites
Metabolites, Vol 11, Iss 409, p 409 (2021)
Metabolites, Vol 11, Iss 409, p 409 (2021)
Pancreatic β-cells are responsible for the synthesis and exocytosis of insulin in response to an increase in circulating glucose. Insulin secretion occurs in a pulsatile manner, with oscillatory pulses superimposed on a basal secretion rate. Insulin
Autor:
Anu Sharma, Aleksey V. Matveyenko, Claudio Cobelli, Adrian Vella, Robert A. Rizza, Marcello C. Laurenti, Ron T. Varghese, Chiara Dalla Man
Publikováno v:
Diabetologia. 60:1483-1490
Shift-work is associated with circadian rhythm disruption and an increased risk of obesity and type 2 diabetes. We sought to determine the effect of rotational shift-work on glucose metabolism in humans. We studied 12 otherwise healthy nurses perform
Autor:
Jeong Heon Lee, Tracy K. Her, Matthew R. Brown, Kuntol Rakshit, Tamas Ordog, Naureen Javeed, Aleksey V. Matveyenko, Zhenqing Ye
Intrinsic β-cell circadian clocks are a prerequisite for the control of glucose homeostasis through regulation of β-cell function and turnover. However, little is known about the contributions of circadian clock disruption to the natural progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27382e49d6ef58246cea81014d1a94a