Zobrazeno 1 - 6
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pro vyhledávání: '"William Y. Kim"'
Publikováno v:
Cell Cycle. 6:2810-2816
The most prevalent mutations associated with the development of clear-cell renal cell carcinoma (CC-RCC) are the loss-of-function mutations of von Hippel-Lindau (VHL) tumor suppressor gene. These mutations invariably result in an inappropriate accumu
Autor:
Marcus Bosenberg, William G. Kaelin, William Y. Kim, Jonathan N. Glickman, Marshall R M Buckley, Meredith M. Regan, Michal Safran, Benjamin L. Ebert
Publikováno v:
The EMBO Journal. 25:4650-4662
Many functions have been assigned to the von Hippel-Lindau tumor suppressor gene product (pVHL), including targeting the alpha subunits of the heterodimeric transcription factor HIF (hypoxia-inducible factor) for destruction. The binding of pVHL to H
Autor:
William G. Kaelin, William Y. Kim
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 22(24)
Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have been linked to the development of sporadic hemangioblastomas and clear-cell re
Publikováno v:
Oxygen Sensing ISBN: 9780121827854
Publisher Summary This chapter focuses on oxygen sensing during the analysis of von Hippel–Lindau (VHL) hereditary cancer syndrome and the implications of oxygen sensing. VHL disease is a hereditary cancer syndrome caused by germline mutations that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fff27ef2545821e4e2f6de2ca3b83662
https://doi.org/10.1016/s0076-6879(04)81022-x
https://doi.org/10.1016/s0076-6879(04)81022-x
Publikováno v:
PLoS Biology, Vol 1, Iss 3, p E83 (2003)
PLoS Biology
PLoS Biology
Biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is linked to the development of hereditary (VHL-associated) and sporadic clear-cell renal carcinomas as well as other abnormalities. The VHL gene product, pVHL, is part of
Autor:
Norman E. Sharpless, William Y. Kim
Publikováno v:
Cancer Cell. (4):295-297
Loss of the VHL tumor suppressor gene promotes cancer in several ways, including activation of the HIF transcription factors. HIF overexpression is associated with increased malignancy in many tumor types. So why is the spectrum of tumors associated