Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Jeffrey J Headd, Kathy N. Williams, Jacqueline B Plesset, Ashley A. Lento, Rosemarie Mick, Andres J. Klein-Szanto, Priya Chatterji, Rei Mizuno, Anil K. Rustgi, Sarah F. Andres, Kathryn E. Hamilton
Publikováno v:
Carcinogenesis
The RNA-binding protein insulin-like growth factor 2 mRNA binding protein 1 (IMP1) is overexpressed in colorectal cancer (CRC); however, evidence for a direct role for IMP1 in CRC metastasis is lacking. IMP1 is regulated by let-7 microRNA, which bind
Publikováno v:
Molecular Carcinogenesis. 54:1122-1131
PACE4 (PCSK6) is a proprotein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco-associated carcinogen benzo[a]pyrene (B(a)P) we investigated whe
Autor:
Daniel E. Bassi, Tianyu Li, Emmanuelle Nicolas, Jirong Zhang, Andres J. Klein-Szanto, Jian Fu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 4, Pp 271-282 (2012)
Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several proteins that contribute to tumor progression. In vitro studies using cancer cell lines and clini
Autor:
Ricardo Garcia, Susana Minguet, Teresa Osteso-Ibánez, Ana Cerezo, Teijo Pellinen, Paloma Sánchez-Mateos, Andres J. Klein-Szanto, Patricia J. Keely, Asier Echarri, Rafael Samaniego, Miguel A. del Pozo, Inmaculada Navarro-Lérida, Enrique Calvo, Jacky G. Goetz, Juan José Lazcano, Edna Cukierman, M. J. Tello
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
eLife
instname
eLife
Marta Tello...et al.
Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is driven by intercellular adhesions, cell contractility, and forces generated within the microenvironment and is dependent on extracel
Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is driven by intercellular adhesions, cell contractility, and forces generated within the microenvironment and is dependent on extracel
RAD001 (Everolimus) Delays Tumor Onset and Progression in a Transgenic Mouse Model of Ovarian Cancer
Autor:
Harvey Hensley, Thomas C. Hamilton, Andres J. Klein-Szanto, Samuel Litwin, Denise C. Connolly, Deborah A. Altomare, Matthew K. Hoelzle, Joseph R. Testa, Seiji Mabuchi
Publikováno v:
Cancer Research. 67:2408-2413
The mammalian target of rapamycin (mTOR) is thought to play a critical role in regulating cell growth, cell cycle progression, and tumorigenesis. Because the AKT-mTOR pathway is frequently hyperactivated in ovarian cancer, we hypothesized that the mT
Autor:
Jonathan D. Cheng, John S. Lee, Hyung-Ok Lee, Leonard R. Henry, Andres J. Klein-Szanto, Eric A. Ross, Wen-Tien Chen, Perry Watts
Publikováno v:
Clinical Cancer Research. 13:1736-1741
Purpose: Human fibroblast activation protein (FAP)/seprase is a 97-kDa surface glycoprotein expressed on tumor associated fibroblasts in the majority of epithelial cancers including colon adenocarcinomas. FAP overexpression in human tumor cells has b
Autor:
Russell J. Schilder, Daniel E. Bassi, Robert E. Page, Eric A. Ross, Samuel Litwin, Andres J. Klein-Szanto, Peter Alexander, Emmanuelle Nicolas, Andrew K. Godwin, Raid Al-Jumaily
Publikováno v:
Cellular Oncology, Vol 29, Iss 4, Pp 289-299 (2007)
Cellular Oncology : the Official Journal of the International Society for Cellular Oncology
Cellular Oncology : the Official Journal of the International Society for Cellular Oncology
Background: Proprotein convertases (PCs) are serine proteases that after restricted proteolysis activate many proteins that play a crucial role in cancer such as metalloproteinases, growth factors and growth factor receptors, adhesion molecules, and
Autor:
Daniel E. Bassi, Edna Cukierman, Ricardo Lopez de Cicco, Jonathan M. Cenna, Samuel Litwin, Andres J. Klein-Szanto
Publikováno v:
Cancer Research. 65:7310-7319
Collagen type IV degradation results in disruption and breakdown of the normal basement membrane architecture, a key process in the initiation of tumor microinvasion into the connective tissue. PACE4, a proprotein convertase, activates membrane type
Publikováno v:
Molecular Carcinogenesis. 44:151-161
Proprotein convertases (PCs) are a group of Ca2+-dependent serine proteases that have homology to the endoproteases subtilisin (bacteria) and kexin (yeast). This group is comprised of less than a dozen members, known as furin/PACE, PC1/PC3, PC2, PC4,
Autor:
James C. Watson, Andres J. Klein-Szanto, Daniel E. Bassi, Ricardo Lopez de Cicco, Samuel Litwin
Publikováno v:
Clinical Cancer Research. 10:4480-4488
Purpose: Squamous cell carcinoma (SCC) of the tongue is a common malignancy of the oral cavity. Furin convertase activates several precursor matrix metalloproteinases involved in the degradation of the extracellular matrix. The pattern of expression