Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Liza Makowski"'
Autor:
Manjul Rana, Rita Kansal, Mehdi Chaib, Bin Teng, Michelle Morrrison, David Neil Hayes, Ansley G. Stanfill, David Shibata, James A. Carson, Liza Makowski, Evan S. Glazer
Publikováno v:
Molecular Carcinogenesis. 61:549-557
Pancreatic ductal adenocarcinoma (PDA) tumors have a highly immunosuppressive desmoplastic tumor microenvironment (TME) where immune checkpoint inhibition (ICI) therapy has been exceptionally ineffective. Transforming growth factor-β (TGF-β) recept
Autor:
Ajeeth K. Pingili, Jared C Clements, Joseph F. Pierre, Mehdi Chaib, Neena A John, Emily B. Korba, Mary C Lovely, Laura M. Sipe, Liza Makowski
Publikováno v:
Cancer Research. 81:PS17-29
Background: Obesity leads to a higher risk of cancer invasion, metastases, recurrence, mortality, and impaired therapeutic response through various mechanisms. One of these mechanisms is microenvironment dysfunction, where changes in immune cells, mi
Autor:
Mehdi, Chaib, Laura M, Sipe, Johnathan R, Yarbro, Margaret S, Bohm, Brittany R, Counts, Ubaid, Tanveer, Ajeeth K, Pingili, Deidre, Daria, Tony N, Marion, James A, Carson, Paul G, Thomas, Liza, Makowski
Publikováno v:
Cancer letters. 531
Myeloid-derived suppressor cells (MDSCs) are an immature innate cell population that expands in pathological conditions such as cancer and suppresses T cells via production of immunosuppressive factors. Conversely, efficient cytotoxic T cell priming
Autor:
Mehdi Chaib, Bilal B. Hafeez, Hassan Mandil, Deidre Daria, Ajeeth K. Pingili, Sonam Kumari, Mohammed Sikander, Vivek K. Kashyap, Guo-Yun Chen, Emmanuel Anning, Manish K. Tripathi, Sheema Khan, Stephen Behrman, Murali M. Yallapu, Meena Jaggi, Liza Makowski, Subhash C. Chauhan
Publikováno v:
Communications biology. 5(1)
There is increasing evidence suggesting the role of microbiome alterations in relation to pancreatic adenocarcinoma and tumor immune functionality. However, molecular mechanisms of the interplay between microbiome signatures and/or their metabolites
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The tumor microenvironment (TME) is a complex network of epithelial and stromal cells, wherein stromal components provide support to tumor cells during all stages of tumorigenesis. Among these stromal cell populations are myeloid cells, which are com
Publikováno v:
Comprehensive Physiology
Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell-intrinsic anomalies. Due to the ubiquitous nature of adipose tiss
Autor:
Hyo Young Choi, Tahliyah S. Mims, Alina M Hamilton, Bin Teng, Katherine L. Cook, D. Neil Hayes, Ajeeth K. Pingili, Emily J. Miller, Joseph F. Pierre, Radhika Sekhri, Deidre Daria, Heejoon Jo, Rahul Sharma, Laura M. Sipe, Ramesh Narayanan, Melissa A. Troester, Liza Makowski, Sarah Asemota, Johnathan R. Yarbro, Tony N. Marion, Mehdi Chaib, Qusai Al Abdallah
Publikováno v:
Cell reports
SUMMARY Immune checkpoint blockade (ICB) has improved outcomes in some cancers. A major limitation of ICB is that most patients fail to respond, which is partly attributable to immunosuppression. Obesity appears to improve immune checkpoint therapies
Autor:
Deidra Daria, Radhika Sekhri, D. Neil Hayes, Mehdi Chaib, Joseph F. Pierre, Rahul Sharma, Mims S Tahliyah, Ajeeth K. Pingili, Heejoon Jo, Laura M. Sipe, Liza Makowski, Bin Teng, Qusai Ai Abdallah, Emily J. Miller
Publikováno v:
Cancer Research. 81:PS17-04
Few targeted therapies exist for triple negative breast cancer (TNBC), an aggressive and deadly subtype. Obesity exacerbates poor outcomes in TNBC due to elevated invasion and metastasis leading to increased mortality. Obesity has paradoxically been
Publikováno v:
Trends in cancer. 4(5)
Obesity has been linked to the increased risk and aggressiveness of many types of carcinoma. A state of chronic inflammation in adipose tissue, resulting in genotoxic stress, may contribute to carcinogenesis and cancer initiation. Evidence that adipo
Autor:
Patricia Casbas-Hernandez, Lindsay J. Lang, Monica D'Arcy, Liza Makowski, Melissa A. Troester, Alex J. Freemerman, Erick Roman-Perez, Katherine A. Hoadley, Charles M. Perou, Heather Ann Brauer
Publikováno v:
Clinical Cancer Research. 19:571-585
Purpose: Cancer cells have altered metabolism, with increased glucose uptake, glycolysis, and biomass production. This study conducted genomic and metabolomic analyses to elucidate how tumor and stromal genomic characteristics influence tumor metabol