Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lance L. Munn"'
Autor:
Mohammad Souri, M. Soltani, Farshad Moradi Kashkooli, Mohammad Kiani Shahvandi, Mohsen Chiani, Fatemeh Sadat Shariati, Mohammad Reza Mehrabi, Lance L. Munn
Publikováno v:
Materials Today Bio, Vol 13, Iss , Pp 100208- (2022)
Nanotechnology in medical applications, especially in oncology as drug delivery systems, has recently shown promising results. However, although these advances have been promising in the pre-clinical stages, the clinical translation of this technolog
Externí odkaz:
https://doaj.org/article/0a1c8dee9ff84e248f794e57c3e0480d
Autor:
Triantafyllos Stylianopoulos, James W. Baish, Chrysovalantis Voutouri, Dan G. Duda, Fotios Mpekris, Lance L. Munn, Rakesh K. Jain
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immunotherapy has changed the standard of care in cancer treatment, but an estimated 87% of patients currently do not derive long-term benefit from immune checkpoint blocker monotherapy. Therefore, new therapeutic strategies are needed t
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports
Scientific Reports
The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. Because in vivo experimental methods are unable to isolate o
Autor:
Hadi Tavakoli Nia, Lance L. Munn
Publikováno v:
Proceedings of the National Academy of Sciences. 116:21960-21962
Experiments and modeling over the past decade have concluded that cells use sophisticated molecular “clutches” at focal adhesions to determine the stiffness of their supporting substrate (1). This mechanism has been shown to modulate a variety of
Publikováno v:
Clinical Cancer Research. 25:2024-2026
The physical microenvironment of pancreatic tumors is highly abnormal, and this causes significant challenges for drug delivery through multiple mechanisms. Measurements of tissue elasticity could be used as a physical biomarker to assess aberrant dr
Autor:
Lance L. Munn, Rakesh K. Jain
Publikováno v:
Science
Blood and lymphatic vessels regulate antitumor immunity through direct and indirect mechanisms, providing new opportunities for improving cancer immunotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3850f860cd72dd25fea14547d686e0ff
https://europepmc.org/articles/PMC7321824/
https://europepmc.org/articles/PMC7321824/
Autor:
Rakesh K. Jain, Triantafyllos Stylianopoulos, James W. Baish, Dan G. Duda, Fotios Mpekris, Chrysovalantis Voutouri, Lance L. Munn
Publikováno v:
Cancer Immunology Research. 9:PO054-PO054
The clinical successes achieved with immune checkpoint blockers (ICBs) have revolutionized the treatment of multiple advanced-stage malignancies. While these responses are often durable, overall only a subset of patients receiving ICBs has thus far e
Publikováno v:
Integrative Biology. 8:1301-1311
Testing the efficacy of cancer drugs requires functional assays that recapitulate the cell populations, anatomy and biological responses of human tumors. Although current animal models and in vitro cell culture platforms are informative, they have si
Solid stress, distinct from both tissue stiffness and fluid pressure, is a mechanical stress that is often elevated in both murine and human tumors. The importance of solid stress in tumor biology has been recognized in initial studies: solid stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f07d67fe3d4e01d34c4f6f79b16f87
https://europepmc.org/articles/PMC6546092/
https://europepmc.org/articles/PMC6546092/
Publikováno v:
Scientific Reports
Angiogenesis requires the coordinated growth and migration of endothelial cells (ECs), with each EC residing in the vessel wall integrating local signals to determine whether to remain quiescent or undergo morphogenesis. These signals include vascula