Zobrazeno 1 - 10
of 61
pro vyhledávání: '"R. Wands"'
Autor:
Kevin P. Charpentier, Qiushi Lin, Howard Safran, Kosuke Ogawa, Lianxin Liu, Fuliang He, Yongwei Wang, Bei Sun, Rui Kong, Songhua Zhang, Katsuya Nagaoka, Hong Zhu, Qinggang Xu, Hua Chen, Jack R. Wands, Rolf I. Carlson, Le Li, Xuesong Chen, Xuewei Bai, Xiaoqun Dong, Min Li
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2019)
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2019)
BackgroundSignaling pathways critical for embryonic development re-emerge in adult pancreas during tumorigenesis. Aspartate β-hydroxylase (ASPH) drives embryonic cell motility/invasion in pancreatic development/differentiation. We explored if dysreg
Autor:
Chiung-Kuei Huang, Xiaoqun Dong, Yoshifumi Iwagami, Qiushi Lin, Grace Jang, Jack R. Wands, Miran Kim, Carl E. Wagner, Mark Olsen, Rolf I. Carlson, John Michael Thomas
Publikováno v:
Hepatology. 63:1213-1226
Aspartate β-hydroxylase (ASPH) is an enzyme overexpressed in human hepatocellular carcinoma (HCC) tumors that participates in the malignant transformation process. We determined if ASPH was a therapeutic target by exerting effects on cellular senesc
Autor:
Qiushi Lin, Shaofan Weng, Zheping Huang, Arihiro Aihara, Christina Nadolny, Waihong Chung, Yu Li, Jack R. Wands, Xuesong Chen, Rolf I. Carlson, Xiaoqun Dong
Publikováno v:
Cancer Lett
The transcriptional factor liver receptor homolog 1 (LRH1) regulates pancreatic development, and may participate in pancreatic oncogenesis through activation of growth factor signaling transduction cascades. We measured transcriptional activity of β
Publikováno v:
Molecular Cancer Research. 8:254-265
The canonical Wnt signaling is frequently activated due to overexpression and/or mutations in components of this pathway in hepatocellular carcinoma (HCC). However, the biological role of noncanonical Wnt-mediated signaling in HCC with respect to the
Autor:
Rhonda F. Souza, Murray B. Resnick, Jose Behar, David Lambeth, Ronald A. DeLellis, Weibiao Cao, Jack R. Wands, Li Juan Wang, Jie Hong, Stuart J. Spechler
Publikováno v:
Gut. 59:170-180
Background and aimsMechanisms of the progression from Barrett's oesophagus to oesophageal adenocarcinoma (OA) are not fully understood. Bile acids may have an important role in this progression. This study aimed at examining the role of NADPH oxidase
Innovations that improve sensitivity and reduce cost are of paramount importance in diagnostic imaging. The novel x-ray imaging modality called Spatial Frequency Heterodyne Imaging (SFHI) is based on a linear arrangement of x-ray source, tissue, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf67560fd2d5bf2999bed4f51621522
https://europepmc.org/articles/PMC4323189/
https://europepmc.org/articles/PMC4323189/
Autor:
Yutaka Sasaki, Masayoshi Horimoto, Masatsugu Hori, Takashi Toyama, Jiro Fujimoto, Tetsuo Takehara, Norio Hayashi, Jack R. Wands, Kenya Iyoda, Mitsuru Sakakibara, Takayuki Yakushijin
Publikováno v:
Cancer. 97:3017-3026
BACKGROUND The mitogen-activated protein kinase (MAPK) cascade is activated in response to various extracellular stimuli. The authors investigated the involvement of the p38 MAPK, a member of the MAPK superfamily, cascade in hepatoma cell lines and i
Autor:
Howard Chang, Stephanie A. Lahousse, Brad Gemelli, Jack R. Wands, Suzanne M. de la Monte, Paul S Sepe, Takashi Maeda
Publikováno v:
Laboratory Investigation. 82:881-891
Aspartyl (asparaginyl) beta-hydroxylase (AAH) is overexpressed in various malignant neoplasms, and high levels of immunoreactivity mainly occur in infiltrating or metastasized tumors. In addition, AAH is abundantly expressed in normally invasive plac
Autor:
Leonhard Mohr, Tim U. Krohne, Bruce L. Roberts, Michael Geissler, Jack R. Wands, Hubert E. Blum, Srinivas Shankara, Seung-Kew Yoon
Publikováno v:
Hepatology. 31:606-614
Expression of viral or bacterial enzymes in tumor cells to convert nontoxic prodrugs into highly toxic metabolites is an attractive gene-therapeutic approach for the treatment of hepatocellular carcinoma (HCC). The Escherichia coli purine nucleoside
Publikováno v:
Biochemical and Biophysical Research Communications. 255:785-791
We evaluated the potential of an intracellularly expressed antibody fragment to interfere with hepatitis B virus (HBV). Sequences coding for the immunoglobulin variable regions of the HBV surface antigen (HBsAg) specific monoclonal antibody 5C3 were