Zobrazeno 1 - 7
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pro vyhledávání: '"Jae J. Song"'
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Biochemical Journal. 373:845-853
Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation. Glucose deprivation disrupted the interaction between TRX/GRX and ASK1 and subsequently activate
Autor:
Yong J. Lee, Jae J. Song
Publikováno v:
Journal of Cellular Biochemistry. 89:653-662
Recently, acute total glucose deprivation has been shown to cause activation of ASK1-MEK-MAPK signal transduction and dissociation of glutaredoxin (GRX) from apoptosis signal-regulating kinase 1 (ASK1). In this study, we investigated whether clinical
Publikováno v:
Molecular Pharmacology. 62:1409-1417
We observed previously that glucose deprivation induces cytotoxicity, increases the intracellular levels of hydroperoxide, and activates the stress-activated protein kinase (SEK) pathway. In this study, we hypothesized that 1-methylpropyl 2-imidazoly
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of cellular biochemistry. 90(2)
Overexpression of catalase, but not manganese superoxide dismutase (MnSOD), inhibited glucose deprivation-induced cytotoxicity and c-Jun N-terminal kinase 1 (JNK1) activation in human prostate adenocarcinoma DU-145 cells. Suppression of JNK1 activati
Autor:
Hyeong Reh Choi Kim, Jin H. Kim, Douglas R. Spitz, Jae J. Song, Young K. Song, Anna Lokshin, Yong J. Lee, Ling Li, R. Rita Siervo-Sassi
Publikováno v:
Experimental cell research. 288(1)
We investigated the role of galectin-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptotic death in human breast carcinoma BT549 cells. We observed that parental galectin-3 null BT549 cells (BT549(par)) as well as con
Autor:
Jae J, Song, Juong G, Rhee, Mohan, Suntharalingam, Susan A, Walsh, Douglas R, Spitz, Yong J, Lee
Publikováno v:
The Journal of biological chemistry. 277(48)
Epitope-tagged glutaredoxin (GRX) was utilized to determine the role of GRX in oxidative stress-induced signaling and cytotoxicity in glucose-deprived human cancer cells (MCF-7/ADR and DU-145). GRX-overexpressing cells demonstrated resistance to gluc
Autor:
Jung Young Kim, Chae-Ok Yun, Heuiran Lee, J. H. Kim, E. Kim, Jae J. Song, Jin Woo Chang, Byeong Ha Lee, Joong Uhn Choi
Publikováno v:
Gene therapy. 8(4)
A retroviral vector constructed from the murine leukemia virus (MLV) can only express transgenes in cells undergoing mitosis, indicating its suitability as a delivery vehicle for cancer gene therapy. However, the transduction efficiency (TE) of retro