Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jenny C. Chang"'
Autor:
Kai Sun, Yitian Xu, Licheng Zhang, Polly Niravath, Jorge Darcourt, Tejal Patel, Bin S. Teh, Andrew M. Farach, Carlo Guerrero, Sunil Mathur, Mark A. Sultenfuss, Nakul Gupta, Mary R. Schwartz, Susan L. Haley, Sindhu Nair, Xiaoxian Li, Thi Truc Anh Nguyen, Joseph D. Butner, Joe Ensor, Jaime A. Mejia, Zhuyong Mei, E. Brian Butler, Shu-hsia Chen, Eric H. Bernicker, Jenny C. Chang
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(20)
Purpose: A Phase 2 trial of stereotactic radiotherapy and in situ cytotoxic virus therapy in patients with metastatic triple-negative breast cancer (mTNBC) followed by pembrolizumab (STOMP) was designed to evaluate dual approach of enhancing single-a
Autor:
Andrew W. Chung, Kartik Anand, Ann C. Anselme, Alfred A. Chan, Nakul Gupta, Luz A. Venta, Mary R. Schwartz, Wei Qian, Yitian Xu, Licheng Zhang, John Kuhn, Tejal Patel, Angel A. Rodriguez, Anna Belcheva, Jorge Darcourt, Joe Ensor, Eric Bernicker, Ping-Ying Pan, Shu Hsia Chen, Delphine J. Lee, Polly A. Niravath, Jenny C. Chang
Publikováno v:
Science translational medicine. 13(624)
The inducible nitric oxide signaling (iNOS) pathway is associated with poor prognosis in triple-negative breast cancer (TNBC). Prior studies using in vivo models showed that inhibition of the iNOS signaling pathway using the pan-NOS inhibitor NG-mono
Publikováno v:
The Breast Journal. 26:1793-1796
Metastatic triple-negative breast cancer (mTNBC) patients tend to have a poor overall survival. The primary goals of treatment focus on palliation of symptoms and improvement in overall survival (OS). Single-agent sequential chemotherapy with anthrac
Autor:
Daniel Davila-Gonzalez, Roberto R. Rosato, Anthony J. Kozielski, Dong Soon Choi, Wei Qian, Jenny C. Chang, Wen Chen, Bhuvanesh Dave, Helen Wong
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-16 (2018)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing this paradigm. In the present study, we examined the in vivo activity of a human
Autor:
Tejal Patel, Toniva Boone, Jenny C. Chang, Angel Rodriguez, Polly A. Niravath, Kartik Anand, Jorge Darcourt, Joe Ensor, Anna Belcheva
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports
Scientific Reports
Triple-negative breast cancer (TNBC) patients who do not achieve pathologic complete response post neoadjuvant chemotherapy have a poor prognosis. Alteration in PI3K/mTOR plus DNA repair pathways are some of the major mechanisms of chemotherapy resis
Autor:
Melinda E. Sanders, Jennifer Bordeaux, Derek A. Franklin, Phillip T. Dean, Justin M. Balko, Jehovana Orozco Bender, Jean Gabriel Judde, Susan R. Opalenik, Christine Vaupel, Jenny C. Chang, Rebecca S. Cook, Violeta Sanchez, Paula I. Ericsson-Gonzalez, Michael T. Lewis, Joe T. Sharick, Stefano Cairo, Gary K. Geiss, Melissa C. Skala, Douglas Hinerfeld
Publikováno v:
JCI Insight
Triple-negative breast cancers (TNBCs) are heterogeneous and aggressive, with high mortality rates. TNBCs frequently respond to chemotherapy, yet many patients develop chemoresistance. The molecular basis and roles for tumor cell–stromal crosstalk
Autor:
Johan Lantto, Jenny C. Chang, Ann Cassany Anselme, Ivan D. Horak, Dong S. Choi, Tejaswini P. Reddy, Wei Qian, Wen Chen, Roberto R. Rosato, Michael Kragh
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Background The human epidermal growth factor receptor (HER) family, notably EGFR, is overexpressed in most triple-negative breast cancer (TNBC) cases and provides cancer cells with compensatory signals that greatly contribute to the survival and deve
Autor:
Helen Piwnica-Worms, Stacy L. Moulder, Jenny C. Chang, Tejaswini P. Reddy, Roberto R. Rosato, Xiaoxian Li
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 22, Iss 1, Pp 1-11 (2020)
Breast Cancer Research, Vol 22, Iss 1, Pp 1-11 (2020)
Metaplastic breast cancer (MpBC) is an exceedingly rare breast cancer variant that is therapeutically challenging and aggressive. MpBC is defined by the histological presence of at least two cellular types, typically epithelial and mesenchymal compon
Autor:
Anthony J. Kozielski, Daniel Davila-Gonzalez, John G. Kuhn, Wen Chen, Jenny C. Chang, Roberto R. Rosato, Helen Wong, Dong Soon Choi, Sergio Granados-Principal, Wen-Feng Li, Wei Qian, Bhuvanesh Dave
Publikováno v:
Clinical Cancer Research. 24:1152-1162
Purpose: Chemoresistance in triple-negative breast cancer (TNBC) is associated with the activation of a survival mechanism orchestrated by the endoplasmic reticulum (EnR) stress response and by inducible nitric oxide synthase (iNOS). Our aim was to d
Autor:
Joe Ensor, Roberto R. Rosato, Bhuvanesh Dave, Stephen T. C. Wong, Wei Qian, Dario Marchetti, Sergio Granados-Principal, Amanda Polley, Jianting Sheng, Olivier Elemento, Anil K. Sood, Dong Soon Choi, Diana Hwang Liang, Zheng Li, Yang Cong, Gabriel Lopez-Berestein, Steve Benz, Melissa D. Landis, Akanksha Verma, Jenny C. Chang, Cristian Rodriguez-Aguayo, Yi Liu, Helen Wong
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 1, Pp 212-227 (2018)
Stem Cell Reports, Vol 10, Iss 1, Pp 212-227 (2018)
Summary Here, we show that HEMATOLOGICAL AND NEUROLOGICAL EXPRESSED 1-LIKE (HN1L) is a targetable breast cancer stem cell (BCSC) gene that is altered in 25% of whole breast cancer and significantly correlated with shorter overall or relapse-free surv