Zobrazeno 1 - 5
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pro vyhledávání: '"Michael R. Wasserman"'
Autor:
Roger B. Altman, Jamie H. D. Cate, Daniel S. Terry, Scott C. Blanchard, Michael R. Wasserman, Jonas Noeske
Publikováno v:
Nature structural & molecular biology
Protein synthesis by the ribosome is highly dependent on the ionic conditions in the cellular environment, but the roles of ribosome solvation remain poorly understood. Moreover, the function of modifications to ribosomal RNA and ribosomal proteins a
Publikováno v:
Annals of the New York Academy of Sciences. 1241:E1-E16
Single-molecule fluorescence imaging has provided unprecedented access to the dynamics of ribosome function, revealing transient intermediate states that are critical to ribosome activity. Imaging platforms have now been developed that are capable of
Publikováno v:
Nature structural & molecular biology
In bacteria, the translocation of tRNA and mRNA with respect to the ribosome is catalyzed by the conserved GTPase, elongation factor-G (EF-G). In order to probe the rate determining features in this process, EF-G-catalyzed translocation was imaged fr
Autor:
Jamie H. D. Cate, Sylvie Garneau-Tsodikova, Arto Pulk, Scott C. Blanchard, John C. Zinder, Keith D. Green, Roger B. Altman, Michael R. Wasserman, Zhou Zhou
Publikováno v:
Nature Communications
Wasserman, Michael R.; Pulk, Arto; Zhou, Zhou; Altman, Roger B.; Zinder, John C.; Green, Keith D.; et al.(2015). Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. Nature Communications, 6. UC Office of the President: Multicampus Research Programs and Initiatives (MRPI); a funding opportunity through UC Research Initiatives (UCRI). Retrieved from: http://www.escholarship.org/uc/item/3jf9k6m1
Wasserman, Michael R.; Pulk, Arto; Zhou, Zhou; Altman, Roger B.; Zinder, John C.; Green, Keith D.; et al.(2015). Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. Nature Communications, 6. UC Office of the President: Multicampus Research Programs and Initiatives (MRPI); a funding opportunity through UC Research Initiatives (UCRI). Retrieved from: http://www.escholarship.org/uc/item/3jf9k6m1
Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the bacterial ribosome connecting helices 44 (h44) and 69 (H69) of the small and large subunit, respectively, impacts translation by controlling intersubunit rotation. Here we s
Autor:
Scott C. Blanchard, Michael R. Wasserman, Leyi Wang, Arto Pulk, Jamie H. D. Cate, Roger B. Altman, Michael Feldman
Publikováno v:
Nature structuralmolecular biology. 19(9)
Protein synthesis is targeted by numerous, chemically distinct antibiotics that bind and inhibit key functional centers of the ribosome. Using single-molecule imaging and X-ray crystallography, we show that the aminoglycoside neomycin blocks aminoacy