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pro vyhledávání: '"Gail V.W. Johnson"'
Autor:
Gail V.W. Johnson, Jeffrey W. Keillor
Publikováno v:
Expert Opinion on Therapeutic Targets. 25:721-731
Introduction : Transglutaminase 2 (TG2) has been implicated in numerous neurological conditions, including neurodegenerative diseases, multiple sclerosis, and CNS injury. Early studies on the role of TG2 in neurodegenerative conditions focused on its
Publikováno v:
Analytical biochemistry. 591
The ubiquitously expressed transglutaminase 2 (TG2) has diverse functions in virtually all cell types, with its role depending not only on cell type, but also on specific subcellular localization. In the central nervous system (CNS) different types o
Publikováno v:
Molecular and Cellular Neuroscience. 86:72-80
The protein transglutaminase 2 (TG2) has been implicated as a modulator of neuronal viability. TG2's role in mediating cell survival processes has been suggested to involve its ability to alter transcriptional events. The goal of this study was to ex
Publikováno v:
NeuroReport. 28:1208-1214
The multifunctional protein transglutaminase 2 (TG2) has been widely implicated as a modulator of cellular viability. Specifically, TG2 expression is beneficial to neuronal survival following an ischemic injury, whereas the opposite is true in astroc
Publikováno v:
Biochemical and Biophysical Research Communications. 482:942-947
Astrocytes play numerous complex roles that support and facilitate the function of neurons. Further, when there is an injury to the central nervous system (CNS) they can both facilitate or ameliorate functional recovery depending on the location and
Publikováno v:
American Journal of Hypertension
BACKGROUND Although numerous recent studies have shown a strong link between inflammation and hypertension, the underlying mechanisms by which inflammatory cytokines induce hypertension remain to be fully elucidated. Hypertensive disorders are also a
Autor:
Heather Natola, Julianne Feola, Christoph Pröschel, Gail V.W. Johnson, Alina Monteagudo, Changyi Ji
Astrocytes play an indispensable role in maintaining a healthy, functional neural network in the central nervous system (CNS). A primary function of CNS astrocytes is to support the survival and function of neurons. In response to injury, astrocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff44d776e42193f6512bafae30e01dd
https://europepmc.org/articles/PMC6218936/
https://europepmc.org/articles/PMC6218936/
Publikováno v:
The European journal of neuroscience. 48(9)
Transglutaminase 2 (TG2) is a protein that modulates neuronal survival processes. Although TG2 is primarily cytosolic, data have suggested the nuclear localization of TG2 is strongly associated with neuronal viability. Depletion of TG2 in neurons res
Autor:
Maria Nurminskaya, Richard L. Eckert, Gozde Colak, Mari T. Kaartinen, Kapil Mehta, Gail V.W. Johnson, Alexey M. Belkin
Publikováno v:
Physiological Reviews. 94:383-417
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease. This review hi
Publikováno v:
Brain research. 1668
Transglutaminase 2 (TG2) is a multifunctional protein that can contribute to cell death and cell survival processes in a variety of disease contexts. Within the brain, TG2 has been shown to promote cell death in ischemic injury when expressed in astr