Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alex M. Jaeger"'
Autor:
Dennis J. Thiele, Daniel W. Neef, Alex M. Jaeger, Rocío Gómez-Pastor, Felix Willmund, Judith Frydman
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 955-966 (2014)
SummaryHeat shock transcription factor 1 (HSF1) is an evolutionarily conserved transcription factor that protects cells from protein-misfolding-induced stress and apoptosis. The mechanisms by which cytosolic protein misfolding leads to HSF1 activatio
Publikováno v:
Nature structural & molecular biology
Heat Shock Transcription Factor (HSF) family members function in stress protection and in human disease including proteopathies, neurodegeneration and cancer. The mechanisms that drive distinct post-translational modifications, co-factor recruitment
Publikováno v:
Nature Reviews Drug Discovery. 10:930-944
Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and prion-based neurodegeneration are associated with the accumulation of misfolded proteins, resulting in neuronal
Publikováno v:
The Journal of biological chemistry, vol 289, iss 44
The heat shock transcription factor 1 (HSF1) activates expression of a variety of genes involved in cell survival, including protein chaperones, the protein degradation machinery, anti-apoptotic proteins, and transcription factors. Although HSF1 acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92f998f198fc6d24471d256d6f279e6
https://europepmc.org/articles/PMC4215228/
https://europepmc.org/articles/PMC4215228/
Publikováno v:
G3: Genes|Genomes|Genetics
Human heat shock transcription factor 1 (HSF1) promotes the expression of stress-responsive genes and is a critical factor for the cellular protective response to proteotoxic and other stresses. In response to stress, HSF1 undergoes a transition from