Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mark A. Dawson"'
Autor:
Veerle W. Daniels, Enid Y.N. Lam, Paloma Cejas, Clifford A. Meyer, Omer Gilan, Mark A. Dawson, Raga Vadhi, Ian E. Krop, Xintao Qiu, Bogdan Pasaniuc, Cynthia X. Ma, Len Taing, Klothilda Lim, Henry W. Long, Nikolas Kesten, Matthew J. Ellis, April C. Watt, Claudia Giambartolomei, Charles C. Bell, Rhiannon Coulson, Shom Goel, Eric P. Winer, Keegan Korthauer, Otto Metzger-Filho, Molly J. DeCristo, Jean J. Zhao, Alba Font-Tello, Haley BrinJones, Anthony Letai, Matthew L. Freedman, Ji-Heui Seo, Myles Brown, Joan Montero
Publikováno v:
Nature cancer, vol 2, iss 1
Nat Cancer
Nat Cancer
Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to induce cancer cell cycle arrest. Recent studies have suggested that these agents also exert other effects, influencing cancer cell immunogenicity, apoptotic respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07391ad275d64c17c054e5bd0859ea39
https://escholarship.org/uc/item/0b43x9f8
https://escholarship.org/uc/item/0b43x9f8
Autor:
Peter Ernest Soden, Emma J. Roberts, Danette L. Daniels, Chun-wa Chung, Stephen John Atkinson, Paul Bamborough, Anne Marie Michon, Johanna Vappiani, Andrea C. Haynes, Massimo Petretich, Marcus Bantscheff, Miriam M. Yeung, Matthew J Bell, Sarah-Jane Dawson, Paola Grandi, Dane Vassiliadis, Simon Taylor, James Gray, Omer Gilan, Kathy Knezevic, Marjeta Urh, Matthew J Lindon, Marian L. Burr, Rab K. Prinjha, Alex Preston, Inmaculada Rioja, Mark A. Dawson, Gerard Drewes, Thilo Werner, Christopher Roland Wellaway, Emmanuel Hubert Demont, Anna K. Bassil, Nicola Harker, Thomas Gobbetti, Enid Y.N. Lam, David F. Tough, Vinod Kumar
Publikováno v:
Science
Bromodomain inhibitors revisited Bromodomain and extraterminal domain (BET) proteins contribute to the pathogenesis of cancer and immune diseases through their effects on transcriptional regulation. BET proteins contain two nearly identical bromodoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f230e3011891f1a84ffe803aee2fab
https://europepmc.org/articles/PMC7610820/
https://europepmc.org/articles/PMC7610820/
Autor:
Ana Rio-Machin, Özgen Deniz, Miguel R. Branco, Mark A. Dawson, Christopher D. Todd, Mamataz Ahmed
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Acute myeloid leukemia (AML) is characterised by a series of genetic and epigenetic alterations that result in deregulation of transcriptional networks. One understudied source of transcriptional regulators are transposable elements (TEs), whose aber
Autor:
Omer Gilan, Helen Ierino, Soroor Hediyeh-Zadeh, Thomas Boudier, Kira Behrens, Tracy A. Willson, Andrew J. Kueh, Ladina DiRago, Warren S. Alexander, Stephen L. Nutt, Kelly L. Rogers, Yih-Chih Chan, Timothy M. Johanson, Sandra Mifsud, Rhys S. Allan, Melissa J. Davis, Mark A. Dawson, Hannah D. Coughlan, Charles C. Bell, Elizabeth M. Viney, Michael Sze Yuan Low, Ashley P. Ng, Craig D. Hyland, Gordon K. Smyth, Marco J Herold, David M. Tarlinton
Summary/AbstractB-cell development is initiated by the stepwise differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating the mature B-cells that mediate protective immunity. This highly regulated process a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964a341948061671b72d3f82a6840407
https://doi.org/10.1101/861542
https://doi.org/10.1101/861542
Autor:
Mark A. Dawson, Charles C. Bell
Publikováno v:
Cancer Cell. 33:1-3
Selectively disrupting oncogenic transcription factors in cancer remains an elusive ambition of targeted therapeutics. In this issue of Cancer Cell, Xu et al. provide an elegant proof-of-concept study demonstrating that interaction between MYB and th
Autor:
Aparna Jayachandran, Rebecca Nightingale, Andrew K. Shiau, Oliver M. Sieber, Panagis Filippakopoulos, Diego Arango, Amardeep S. Dhillon, Beatriz Diez-Dacal, John M. Mariadason, Mark A. Dawson, Timothy C. Gahman, Rui Wu, Hoanh Tran, Toby J. Phesse, Anderly C. Chueh, Lars Tögel
Publikováno v:
Molecular Cancer Therapeutics. 15:1217-1226
Inhibitors of the bromodomain and extraterminal domain (BET) protein family attenuate the proliferation of several tumor cell lines. These effects are mediated, at least in part, through repression of c-MYC. In colorectal cancer, overexpression of c-
Autor:
Margaret A. Goodell, Yun Huang, Mark A. Dawson, Jia Li, Clifford Stephan, Anna Guzman, Lei Guo, Deqiang Sun, Peter J.A. Davies, Yubin Zhou, Tingting Li, Minjung Lee, Hongxiang Zeng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Primary and acquired drug resistance imposes a major threat to achieving optimized clinical outcomes during cancer treatment. Aberrant changes in epigenetic modifications are closely involved in drug resistance of tumor cells. Using BET inhibitor (BE
Autor:
Julia Spindel, Mario Iurlaro, Pierre Murat, Mark A. Dawson, Guillem Portella, Sergio Martínez Cuesta, Wolf Reik, Robyn Hardisty, Shankar Balasubramanian, Zhe Li, Eun-Ang Raiber, Wendy Dean, Dario Beraldi
Nucleosomes are the basic unit of chromatin that ensure genome integrity and control access to the genetic information. The organization of nucleosomes is influenced by the underlying DNA sequence itself, transcription factors or other transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81617abf204a674a3dd63edc431749f9
Autor:
Andrew J. Murphy, Grace Liu, Giovanna Pomilio, Cécile Esnault, Meaghan Wall, Andrew H. Wei, Ladina DiRago, Margherita Ghisi, Donald Metcalf, Emilia Simankowicz, Mark A. Dawson, Luyi Tian, Shalin H. Naik, Stephen L. Nutt, Charles C. Bell, Michael Erlichster, Pavle Krsmanovic, Ruijie Liu, Shian Su, Ethan P. Oxley, Luisa Cimmino, Matthew T. Witkowski, Aleksandar Dakic, Matthew E. Ritchie, Johannes Zuber, Tina Vu, Ricky W. Johnstone, Nouraiz Ahmed, Daniela Zalcenstein, Timm Schroeder, Steven Ngo, Tracey M. Baldwin, Mark D. McKenzie, Jessica M. Salmon, V Pospisil, Graeme I. Lancaster, Ross A. Dickins, Shu Wang, Michael Chopin, Ben A. Croker
Publikováno v:
Cell Stem Cell, 25 (2)
Tumors are composed of phenotypically heterogeneous cancer cells that often resemble various differentiation states of their lineage of origin. Within this hierarchy, it is thought that an immature subpopulation of tumor-propagating cancer stem cells
Autor:
Omer Gilan, Chun Yew Fong, Isabelle Becher, Andrew J. Bannister, Neil Stuart Garton, Enid Y.N. Lam, Mark A. Dawson, Gerard Drewes, Sarah-Jane Dawson, David Smil, Gerard Joberty, Dave Lugo, Ricky W. Johnstone, Rab K. Prinjha, Sarah Ftouni, Laura MacPherson, Margherita Ghisi, Aoife Ward, Brian J. P. Huntly, Dean Tyler, Meike Wiese, Paola Grandi, Christopher L. Carpenter, Tony Kouzarides, Ester Cannizzaro, Yih-Chih Chan, Cheryl H. Arrowsmith, Kym Stanley, Marnie E. Blewitt, Chen-Fang Weng, Peter Brown
Publikováno v:
Nature Structural & Molecular Biology
Targeted therapies against disruptor of telomeric silencing 1-like (DOT1L) and bromodomain-containing protein 4 (BRD4) are currently being evaluated in clinical trials. However, the mechanisms by which BRD4 and DOT1L regulate leukemogenic transcripti