Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Huck-Hui Ng"'
Autor:
May Yin Lee, Zhi Han Lim, Yun Shen Chan, Feng Li, Atsushi Suzuki, Edward Kai-Hua Chow, Glenn Kunnath Bonney, John M. Asara, Alicia Stein, Matan Thangavelu Thangavelu, Yoganathan Kanagasundaram, Tan Boon Toh, Guo-Dong Lu, Joanna Z. Yeo, Hong Kee Tan, Kol Jia Yong, Siyu Wang, Justin L. Tan, Chung Yan Leong, Yock Young Dan, Chan Shuo Wu, Giridharan Periyasamy, Zi Hui Tan, Bee Hui Liu, Siming Ma, Wai Leong Tam, Huck-Hui Ng, Guo Hao Ng, Siew Bee Ng, Lissa Hooi, Nikki R. Kong, Tim Chan, Daniel G. Tenen, Li Chai, Kia Ngee Low, Mahmoud A. Bassal, Yue Wu
Publikováno v:
Gastroenterology
Background & Aims Some oncogenes encode transcription factors, but few drugs have been successfully developed to block their activity specifically in cancer cells. The transcription factor SALL4 is aberrantly expressed in solid tumor and leukemia cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d870803882ebda006613d11fea7366ed
https://europepmc.org/articles/PMC7309153/
https://europepmc.org/articles/PMC7309153/
Autor:
Willie Yu, Angie Lay Keng Tan, Patrick Tan, Xin Xiu Sam, Niantao Deng, Jeanie Wu, Wei Keat Wan, Steve Rozen, Na-Yu Chia, Su-Ting Tay, Yansong Zhu, Wai-Keong Wong, Anna Gan, Kakoli Das, Lourdes Trinidad M Dominguez, Gek San Tan, Minghui Lee, Khee Chee Soo, Longyu Hu, Bin Tean Teh, Kiat Hon Lim, Huck-Hui Ng, Dachuan Huang, Liang Kee Goh
Publikováno v:
Europe PubMed Central
Objective Gastric cancer (GC) is a deadly malignancy for which new therapeutic strategies are needed. Three transcription factors, KLF5, GATA4 and GATA6, have been previously reported to exhibit genomic amplification in GC. We sought to validate thes
Publikováno v:
Stem Cells. 32:1805-1816
Master transcription factors Oct4, Sox2, and Nanog are required to maintain the pluripotency and self-renewal of embryonic stem cells (ESCs) by regulating a specific transcriptional network. A few other transcription factors have been shown to be imp
Autor:
Huck-Hui Ng, Jia-Chi Yeo
Publikováno v:
Cell Research. 23:20-32
The defining features of embryonic stem cells (ESCs) are their self-renewing and pluripotent capacities. Indeed, the ability to give rise into all cell types within the organism not only allows ESCs to function as an ideal in vitro tool to study embr
Autor:
Huck-Hui Ng, M. Azim Surani
Publikováno v:
Nature Cell Biology. 13:490-496
Pluripotency and self-renewal are the hallmarks of embryonic stem cells. This state is maintained by a network of transcription factors and is influenced by specific signalling pathways. Current evidence indicates that multiple pluripotent states can
Autor:
Thomas Lufkin, Mikael Huss, Yuriy L. Orlov, Jian-Chien Dominic Heng, Petra Kraus, Jianyong Han, Jianming Jiang, Lin Yang, Bo Feng, Huck-Hui Ng, Jia-Hui Ng, Bing Lim
Publikováno v:
Cell Stem Cell. 6:167-174
SummarySomatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the introduction of Oct4, Sox2, Klf4, and c-Myc. Among these four factors, Oct4 is critical in inducing pluripotency because no transcription factor can substitut
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 75:237-244
Pluripotency and self-renewal are the defining traits of embryonic stem cells (ESCs) and this status quo is maintained by the core transcription factors Oct4, Sox2, and Nanog. Genome-wide mapping of the binding sites of these pivotal factors and othe
Autor:
Na-Yu Chia, Andre Choo, Yun-Shen Chan, Hui Shan Sim, Jingyao Zhang, Ker Sin Tan, Steve Oh, Ken Kwok-Keung Chan, Huck-Hui Ng
Publikováno v:
Stem Cells. 27:2114-2125
Insight into the regulation of core transcription factors is important for a better understanding of the molecular mechanisms that control self-renewal and pluripotency of human ESCs (hESCs). However, the transcriptional regulation of NANOG itself in
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 647:52-58
Embryonic stem cells (ESCs) are characterized by their broad developmental potential and the capacity to self-renew. The advent of high-throughput technologies has facilitated genome-wide studies of transcriptional network, resulting in an ever-incre
Autor:
Yupo Ma, Boon Seng Soh, Bing Lim, Li Chai, Hsiao-Yun Chan, Wai Leong Tam, Paul Robson, Thomas Lufkin, Jianchang Yang, Qiang Wu, Yuefei Lou, Jinqiu Zhang, Huck-Hui Ng, Guo Qing Tong
Publikováno v:
Nature Cell Biology. 8:1114-1123
Embryonic stem (ES) cells are pluripotent cells that can self-renew or differentiate into many cell types. A unique network of transcription factors and signalling molecules are essential for maintaining this capability. Here, we report that a spalt