Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hiroyuki Miyachi"'
Autor:
Shuichi Hirono, Makoto Makishima, Atsushi Aoyama, Hiroyuki Miyachi, Takuji Oyama, Yuichi Hashimoto, Kosuke Morikawa, Jun Ichi Kasuga, Kumiko Sako, Izumi Nakagome
Publikováno v:
YAKUGAKU ZASSHI. 129:709-718
A series of 3-(4-alkoxypheny)propanoic acid derivatives was prepared as candidate peroxisome proliferator-activated receptor (PPAR) delta-selective agonists, based on our previously discovered potent human PPARalpha/delta dual agonist TIPP-401 as a l
Autor:
Shigeyuki Uno, Yangsik Jeong, Yuichi Hashimoto, Makoto Makishima, Kaori Endo, Katsuyoshi Kawana, Hiroyuki Miyachi
Publikováno v:
Biochemical Pharmacology. 77:186-195
The nuclear receptors liver X receptor (LXR) alpha and LXRbeta serve as oxysterol receptors and play an important role in the regulation of lipid metabolism. We investigated the potential effects of LXRs on pathways of colon carcinogenesis and found
Autor:
Yuko Hirakawa, Hiroyuki Miyachi, Kosuke Morikawa, Makoto Makishima, Takuji Oyama, Yuichi Hashimoto, Jun Ichi Kasuga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4525-4528
We developed a potent peroxisome proliferator-activated receptor pan agonist (a candidate drug for treatment of altered metabolic homeostasis) by introducing fluorine atoms at appropriate position(s) of the known phenylpropionic acid-type pan agonist
Publikováno v:
Chemicalpharmaceutical bulletin. 62(5)
Hesperidin, a flavanone glycoside present abundantly in citrus fruits, is predominantly metabolized to hesperetin-7-O-β-D-glucuronide (H7-OG) and hesperetin-3'-O-β-D-glucuronide (H3'-OG), which exhibit partial agonistic activity towards peroxisome
Autor:
Ko Fujimori, Yangsik Jeong, Kaori Endo-Umeda, Shigeyuki Uno, Hiroyuki Miyachi, Sachiko Yamada, Hiroaki Tokiwa, Yoshikazu Naito, Koichi Saito, Makoto Makishima, Kenji Yamagishi
Publikováno v:
Molecular pharmacology. 81(6)
The liver X receptor α (LXRα) is a nuclear receptor that is involved in regulation of lipid metabolism, cellular proliferation and apoptosis, and immunity. In this report, we characterize three human LXRα isoforms with variation in the ligand-bind
Autor:
Hiroyuki Miyachi, Tomohiro Ide, Koji Murakami, Masaki Tsunoda, Katsuya Awano, Masahiro Nomura, Takahiro Tanase, Takahashi Yukie
Publikováno v:
ChemInform. 33
A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure–activity relationship studies indicated that the substitue
Autor:
Katsuya Awano, Masahiro Nomura, Hiroyuki Miyachi, Koji Murakami, Takahiro Tanase, Masahiro Suzuki
Publikováno v:
ChemInform. 33
Optically active phenylpropanoic acid derivatives [( S )- 5 , and ( R )- 5 ] were prepared, and their affinities for peroxisome proliferator-activated receptor (PPAR)α and PPARγ were evaluated. Binding assay and cell-based reporter assay indicated
Autor:
Takuji Oyama, Hiroyuki Miyachi, Yuichi Hashimoto, Shuichi Hirono, Kumiko Sako, Izumi Nakagome, Atsushi Aoyama, Jun Ichi Kasuga, Makoto Makishima, Kosuke Morikawa
Publikováno v:
ChemInform. 40
A series of 3-(4-alkoxypheny)propanoic acid derivatives was prepared as candidate peroxisome proliferator-activated receptor (PPAR) delta-selective agonists, based on our previously discovered potent human PPARalpha/delta dual agonist TIPP-401 as a l
Autor:
Takuji Ohyama, Hiroyuki Miyachi, Kenji Ohgane, Makoto Makishima, Yuko Hirakawa, Kosuke Morikawa, Jyun Ichi Kasuga, Yuichi Hashimoto
Publikováno v:
ChemInform. 39
Conformationally restricted heterocyclic derivatives of KCL ((S)-2-{4-methoxy-3-[4-(trifluoromethyl)benzylcarbamoyl]benzyl)butanoic acid), which exhibit selective PPARα-agonistic activity, were prepared to examine the significance of the amide bond
Autor:
Hiroyuki Miyachi, Michitaka Ogura, Michiyasu Ishizawa, Yuichi Hashimoto, Atsushi Aoyama, Makoto Makishima, Kumiko Sako, Izumi Nakagome, Jun Ichi Kasuga, Shuichi Hirono
Publikováno v:
Bioorganicmedicinal chemistry. 15(15)
A series of 3-(4-alkoxyphenyl)propanoic acid derivatives was prepared as candidate peroxisome proliferator-activated receptor (PPAR) delta-selective agonists, based on our previously discovered potent human PPARalpha/delta dual agonist TIPP-401 as a