Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Chen-Ming Fan"'
Publikováno v:
Development. 130:6233-6243
Sonic hedgehog (Shh) signaling is essential for sclerotome development in the mouse. Gli2 and Gli3 are thought to be the primary transcriptional mediators of Shh signaling; however, their roles in Shh induction of sclerotomal genes have not been inve
Publikováno v:
Development. 127:4701-4709
The secreted protein sonic hedgehog (Shh) is required to establish patterns of cellular growth and differentiation within ventral regions of the developing CNS. The expression of Shh in the two tissue sources responsible for this activity, the axial
Publikováno v:
Development. 127:109-118
Dorsoventral polarity of the somitic mesoderm is established by competitive signals originating from adjacent tissues. The ventrally located notochord provides the ventralizing signals to specify the sclerotome, while the dorsally located surface ect
Autor:
Richard M. Harland, Chen-Ming Fan, Jill A. McMahon, Shinji Takada, Andrew P. McMahon, Lyle B. Zimmerman
Publikováno v:
Genes & Development. 12:1438-1452
Embryonic patterning in vertebrates is dependent upon the balance of inductive signals and their specific antagonists. We show thatNoggin, which encodes a bone morphogenetic protein (BMP) antagonist expressed in the node, notochord, and dorsal somite
Publikováno v:
Developmental Biology. 191(1):160-165
Dorsoventral patterning of somites into sclerotome and dermomyotome involves antagonistic actions of ventralizing and dorsalizing signals originating from tissues surrounding the somites. The notochord and the floor plate of the neural tube provide a
Autor:
Chen-Ming Fan, Marc Tessier-Lavigne
Publikováno v:
Cell. 79:1175-1186
An early step in the development of vertebrae, ribs, muscle, and dermis is the differentiation of the somitic mesoderm into dermomyotome dorsally and sclerotome ventrally. To analyze this process, we have developed an in vitro assay for somitic mesod
Publikováno v:
Nature. 433(7023)
Select members of the Wnt family of secreted glycoproteins have been implicated in inducing the myogenic determinant genes Pax3, MyoD and Myf5 during mammalian embryogenesis, but the mechanism of induction has not been defined. We describe an unexpec
Autor:
Chen-Ming Fan, Gregory Marques
Publikováno v:
Cerebellum (London, England). 1(4)
Cell proliferation is an essential force to build up the size, shape, and function of an organ. This force is particularly prominent in the production of the cerebellar granule neurons, which represent 80% of all brain neurons. Extensive cell biologi
Publikováno v:
Developmental biology. 258(1)
WNT signaling plays a major role in patterning the dermomyotome of the somitic mesoderm. However, knowledge of downstream target genes and their regulation is limited. To identify new genes involved in the development and early patterning of the somi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(20)
The dorsal–ventral polarity of the somite is controlled by antagonistic signals from the dorsal neural tube/surface ectoderm, mediated by WNTs, and from the ventral notochord, mediated by sonic hedgehog (SHH). Each factor can act over a distance gr