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pro vyhledávání: '"Tatsuya Toma"'
Autor:
Nagayasu Nakajima, Eiji Yoshida, Tatsuya Toma, Yoshitake Nishiyama, Masayuki Inoue, Tohru Fukuyama, Satoshi Yokoshima
Publikováno v:
Organic letters. 24(44)
A synthetic route to ecteinascidin 743 has been established via an intramolecular cascade Heck reaction to construct the diazabicyclo[3.3.1]nonane skeleton while controlling the two contiguous stereogenic centers. The strategically formed five-member
Publikováno v:
Journal of the American Chemical Society. 135:13684-13687
A straightforward synthesis of ecteinascidin 743 was accomplished from readily available l-glutamic acid as a single chiral source. Our novel synthesis features a concise and convergent approach for construction of the B-ring, consisting of a sequenc