Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Xinxin Ding"'
Autor:
Hans-Joachim Lehmler, Eric Uwimana, Laura E. Dean, Nataliia Kovalchuk, Qing-Yu Zhang, Xinxin Ding
Publikováno v:
Chemical research in toxicology. 35(12)
Chiral polychlorinated biphenyls (PCB) are environmentally relevant developmental neurotoxicants. Because their hydroxylated metabolites (OH-PCBs) are also neurotoxic, it is necessary to determine how PCB metabolism affects the developing brain, for
Publikováno v:
Toxicol Sci
Previous studies have established that cytochrome P450 enzymes (CYPs) in both liver and lung are capable of bioactivating naphthalene (NA), an omnipresent air pollutant and possible human carcinogen, in vitro and in vivo. The aim of this study was to
Autor:
Senyan Liu, Stewart Sell, Lei Li, Kathleen G. Dickman, Changlin Mei, Xinxin Ding, Xiaochen Bao, Liang Ding, Jun Gu, Qing Yu Zhang
Publikováno v:
Toxicol Sci
The effect of variations in the expression of cytochrome P450 reductase (CPR or POR) is determined in mice with decreased POR expression to identify potential vulnerabilities in people with low POR expression. There is an age-dependent appearance of
Autor:
Oliver Fiehn, Nathanial C. Stevens, Laura S. Van Winkle, Xinxin Ding, Lisa M. Tran, Patricia C. Edwards
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology, vol 184, iss 2
Toxicol Sci
Toxicol Sci
Naphthalene is a ubiquitous environmental contaminant produced by combustion of fossil fuels and is a primary constituent of both mainstream and side stream tobacco smoke. Naphthalene elicits region-specific toxicity in airway club cells through cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9612ae4e68d4da297608a647dbc7e51
https://escholarship.org/uc/item/7n94c2cv
https://escholarship.org/uc/item/7n94c2cv
Autor:
Xinxin Ding, Laura S. Van Winkle, Nicole M. Collette, Matthew Hartog, Bruce A. Buchholz, Edward A. Kuhn, Sarah A. Carratt
Publikováno v:
Toxicol Lett
Naphthalene (NA) is a ubiquitous environmental pollutant and possible human carcinogen that forms tumors in rodents with tissue/regional and species selectivity. This study seeks to determine whether NA is able to directly adduct DNA in an ex vivo cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9122f9d767a96dbb5f24e9787e252ade
https://escholarship.org/uc/item/7w25m74s
https://escholarship.org/uc/item/7w25m74s
Publikováno v:
Toxicol Sci
Human exposure to naphthalene (NA), an acute lung toxicant and possible human carcinogen, is primarily through inhalation. Acute lung toxicity and carcinogenesis are thought to be related because the target sites for both are similar. To understand s
Publikováno v:
Toxicol Sci
Many constituents of tobacco smoke (TS) require bioactivation to exert toxic effects; however, few studies have examined the role of bioactivation enzymes in the adverse effects of TS exposure. This knowledge gap is a major source of uncertainty for
Publikováno v:
Chemical Research in Toxicology. 29:797-809
Albumin is a commonly used serum protein for studying human exposure to xenobiotic compounds, including therapeutics and environmental pollutants. Often, the reactivity of albumin with xenobiotic compounds is studied ex vivo with human albumin or pla
Autor:
Nataliia Kovalchuk, Yanan Wang, Matthew Hartog, Sarah A. Carratt, Lei Li, Patricia C. Edwards, Qing Yu Zhang, Xinxin Ding, Laura S. Van Winkle, Kunzhi Jia
Publikováno v:
Environmental health perspectives, vol 125, iss 6
Environmental Health Perspectives
Environmental Health Perspectives
Background: The potential carcinogenicity of naphthalene (NA), a ubiquitous environmental pollutant, in human respiratory tract is a subject of intense debate. Chief among the uncertainties in risk assessment for NA is whether human lung CYP2A13 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cf0f17ae1b890aa1a66416918f7c61
https://escholarship.org/uc/item/0qp5m9mz
https://escholarship.org/uc/item/0qp5m9mz
Autor:
Qing Yu Zhang, Lei Li, Laura S. Van Winkle, Patricia C. Edwards, Nataliia Kovalchuk, Xinxin Ding, Matthew Hartog, Jacklyn S. Kelty
We determined whether a decrease in hepatic microsomal cytochrome P450 activity would impact lung toxicity induced by inhalation exposure to naphthalene (NA), a ubiquitous environmental pollutant. The liver-Cpr-null (LCN) mouse showed decreases in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef6068b17672f50c635fff0c9b5b1b2
https://europepmc.org/articles/PMC6398949/
https://europepmc.org/articles/PMC6398949/