Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Philip T. Liu"'
Autor:
Rosane M. B. Teles, Philip T. Liu, Robert L. Modlin, Nathan W. Schmidt, Mirjam Schenk, Matteo Pellegrini, Gerard C. L. Wong, Susan Realegeno, Thomas H. Rea, Kindra M. Kelly-Scumpia, Ernest Y. Lee, Maria Teresa Ochoa, Angeline Tilly Dang, Jing Lu, Euzenir Nunes Sarno
Publikováno v:
PLoS Pathogens
Realegeno, Susan; Kelly-Scumpia, Kindra M; Dang, Angeline Tilly; Lu, Jing; Teles, Rosane; Liu, Philip T; Schenk, Mirjam; Lee, Ernest Y; Schmidt, Nathan W; Wong, Gerard C L; Sarno, Euzenir N; Rea, Thomas H; Ochoa, Maria T; Pellegrini, Matteo; Modlin, Robert L (2016). S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS pathogens, 12(6), e1005705. Public Library of Science 10.1371/journal.ppat.1005705
PLoS pathogens, vol 12, iss 6
PLoS Pathogens, Vol 12, Iss 6, p e1005705 (2016)
Realegeno, Susan; Kelly-Scumpia, Kindra M; Dang, Angeline Tilly; Lu, Jing; Teles, Rosane; Liu, Philip T; Schenk, Mirjam; Lee, Ernest Y; Schmidt, Nathan W; Wong, Gerard C L; Sarno, Euzenir N; Rea, Thomas H; Ochoa, Maria T; Pellegrini, Matteo; Modlin, Robert L (2016). S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS pathogens, 12(6), e1005705. Public Library of Science 10.1371/journal.ppat.1005705
PLoS pathogens, vol 12, iss 6
PLoS Pathogens, Vol 12, Iss 6, p e1005705 (2016)
Triggering antimicrobial mechanisms in macrophages infected with intracellular pathogens, such as mycobacteria, is critical to host defense against the infection. To uncover the unique and shared antimicrobial networks induced by the innate and adapt
Autor:
Songyang Ren, Robert L. Modlin, Niels Borregaard, Martin Hewison, John S. Adams, Adrian F. Gombart, Rene F. Chun, Venu Lagishetty, Philip T. Liu
Publikováno v:
The Journal of Immunology. 182:4289-4295
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) enhances innate immunity by inducing the cathelicidin antimicrobial peptide (hCAP). In monocytes/macrophages, this occurs primarily in response to activation of TLR, that induce expre
Autor:
Robert L. Modlin, John S. Adams, Juan Antonio Robles, Steffen Stenger, Stephan R. Krutzik, Martin Hewison, Philip T. Liu
Publikováno v:
The Journal of Immunology. 181:7115-7120
An essential function of the innate immune system is to directly trigger antimicrobial mechanisms to defend against invading pathogens. In humans, one such pathway involves activation by TLR2/1L leading to the vitamin D-dependent induction of antimic
Autor:
Jenny Kim, Melissa Kanchanapoomi, Dominic Ho-Ping Tang, Brian E. Hall, Jenny Phan, Stephan R. Krutzik, Philip T. Liu
Publikováno v:
The Journal of Immunology. 180:4919-4923
Propionibacterium acnes is a major etiological factor of acne, triggering an inflammatory response in part through the activation of TLR2. In this study, we demonstrate that activation of peripheral blood monocytes with P. acnes in vitro induced thei
Publikováno v:
Trends in Molecular Medicine. 13:117-124
The innate immune system provides the host with an immediate and rapid defense against invading microbes. Detection of foreign invaders is mediated by a class of receptors that are known as the pattern recognition receptors, such as the family of Tol
Publikováno v:
The Journal of Immunology. 174:2467-2470
A major consequence of microbial infection is the tissue injury that results from the host inflammatory response. In acne, inflammation is due in part to the ability of Propionibacterium acnes to activate TLR2. Because all-trans retinoic acid (ATRA)
Autor:
Philip T. Liu
Publisher Summary Rapid detection and antimicrobial activity against microbes are considered to be key direct functions of innate immune cells in relation to infection control. Many studies have identified genes which may confer some degree of suscep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a115d7a327fc5cc531b1c99615d09d
https://doi.org/10.1016/b978-0-12-381978-9.10093-9
https://doi.org/10.1016/b978-0-12-381978-9.10093-9
Autor:
Manali Mehta, Evangelia Komisopoulou, Thomas H. Rea, Euzenir Nunes Sarno, Aria Vazirnia, Thomas G. Graeber, Rosane M. B. Teles, Robert L. Modlin, Benjamin G. Ferguson, Philip T. Liu, Kristina Edfeldt, Matthew Wheelwright
Publikováno v:
Nature medicine
Leprosy provides a model to investigate mechanisms of immune regulation in humans, given that the disease forms a spectrum of clinical presentations that correlate with host immune responses. Here we identified 13 miRNAs that were differentially expr
Autor:
Caroline Keegan, Martin Hewison, John S. Adams, Mirjam Schenk, Kristina Edfeldt, Philip T. Liu, Stephan R. Krutzik, Mario Fabri, Rene F. Chun, Robert L. Modlin, Matthew Wheelwright
We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway in human monocytes. T-cell cytokines differentially influenced TLR2/1-induced expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfab370709ffe28b142337b78b2dbf14
Autor:
Melissa Kanchanapoomi, Ulrich Zügel, Genhong Cheng, Mirjam Schenk, Robert L. Modlin, Andreas Steinmeyer, Xiaoran Zhang, Matthew Wheelwright, Philip T. Liu, Aria Vazirnia, Paul W. Dempsey, Valencia P. Walker, Bruce W. Hollis
Publikováno v:
Liu, Philip T; Schenk, Mirjam; Walker, Valencia P; Dempsey, Paul W; Kanchanapoomi, Melissa; Wheelwright, Matthew; Vazirnia, Aria; Zhang, Xiaoran; Steinmeyer, Andreas; Zügel, Ulrich; Hollis, Bruce W; Cheng, Genhong; Modlin, Robert L (2009). Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS ONE, 4(6), e5810. Public Library of Science 10.1371/journal.pone.0005810
PLoS ONE
PloS one, vol 4, iss 6
PLoS ONE, Vol 4, Iss 6, p e5810 (2009)
PLoS ONE
PloS one, vol 4, iss 6
PLoS ONE, Vol 4, Iss 6, p e5810 (2009)
Antimicrobial effector mechanisms are central to the function of the innate immune response in host defense against microbial pathogens. In humans, activation of Toll-like receptor 2/1 (TLR2/1) on monocytes induces a vitamin D dependent antimicrobial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60b43ea362f30d13c7a16c845f77b3b
https://boris.unibe.ch/102306/1/19503839.PDF
https://boris.unibe.ch/102306/1/19503839.PDF