Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Shuwen Lei"'
Autor:
Muhammet M Öztürk, Bryce L Mashimo, Maria Medalla, Lulu Jiang, Samantha Boudeau, Peter E.A. Ash, Guillermo Socorro, Jenifer Shattuck, Susanne Wegmann, Pavel Ivanov, Yari Carlomagno, Nicholas M. Kanaan, Benjamin Wolozin, Mark Knobel, Leonard Petrucelli, Shuwen Lei, Louloua F A Al-Mohanna
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(9), e2014188118-(2021). doi:10.1073/pnas.2014188118
Proceedings of the National Academy of Sciences of the United States of America 118(9), e2014188118-(2021). doi:10.1073/pnas.2014188118
Significance Phase separation of proteins is increasingly thought to play a fundamental role in biological processes. Recent studies show that tau protein phase separates, but the biological significance is unknown since artificial crowding agents ar
Autor:
Johnathan F. Crary, Victor E. Alvarez, Brandon F. Maziuk, Leonard Petrucelli, Peter E.A. Ash, Benjamin Wolozin, Rakez Kayed, Nicholas M. Kanaan, Lulu Jiang, Shuwen Lei, Jaehyup Song, Emily van Vliet, Andrew Emili, Cheng Zhang, Weiwei Lin, Samantha Boudeau, Mamta Verma, Hu E Li, Melissa E. Murray, Anna Lourdes Cruz, Julian Kwan
SummaryThe microtubule associated protein tau oligomerizes in response to stress and disease, but the function of oligomeric tau (oTau) and the ultimate mechanisms of toxicity are unknown. To gain insights, we have now used Cry2-based optogenetics to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6489cffb94be6b9745b55cfeccf3fdb6
https://doi.org/10.1101/2020.12.03.409334
https://doi.org/10.1101/2020.12.03.409334
Autor:
Peter E.A. Ash, John F. Crary, Rakez Kayed, Lulu Jiang, Samantha Boudeau, Nicholas M. Kanaan, Hu Li, Julian Kwan, Anna Lourdes Cruz, Andrew Emili, Cheng Zhang, Weiwei Lin, Victor E. Alvarez, Jaehyup Song, Melissa E. Murray, Leonard Petrucelli, Brandon F. Maziuk, Mamta Verma, Emily van Vliet, Benjamin Wolozin, Shuwen Lei
Publikováno v:
SSRN Electronic Journal.
The microtubule associated protein tau oligomerizes in response to stress and disease, but the function of oligomeric tau (oTau) and the ultimate mechanisms of toxicity are unknown. To gain insights, we have now used Cry2-based optogenetics to induce
Autor:
Victor E. Alvarez, Julian Kwan, Brandon F. Maziuk, John F. Crary, Samantha Boudeau, Melissa E. Murray, Hu Li, Emily van Vliet, Jaehyup Song, Andrew Emili, Mamta Verma, Lulu Jiang, Peter E.A. Ash, Cheng Zhang, Weiwei Lin, Benjamin Wolozin, Nicholas M. Kanaan, Anna Lourdes Cruz, Shuwen Lei, Leonard Petrucelli
Publikováno v:
SSRN Electronic Journal.
We combine optogenetics with proteomics for time-resolved identification of tau oligomer (oTau) protein interactomes. Optically induced tau oligomerization is elicits a translational stress response exhibiting increased cytoplasmic localization of N6