Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ke Wan"'
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107236- (2024)
The rapid antidepressant effects of ketamine depend on the N-methyl-D-aspartate (NMDA) receptor containing 2B subunit (NR2B), whose function is influenced by its phosphorylated regulation and distribution within and outside synapses. It remains uncle
Externí odkaz:
https://doaj.org/article/d843223db8d444acaca81dd1eb1538c6
Autor:
Jianying Yin, Yuanfeng Huang, Ke Wang, Qin Zhong, Yuan Liu, Zirui Ji, Yiwen Liao, Zhiyuan Ma, Weijian Bei, Weixuan Wang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionPanax ginseng C. A. Mey. (Araliaceae; Ginseng Radix et Rhizoma), a traditional plant commonly utilized in Eastern Asia, has demonstrated efficacy in treating neuro-damaging diseases and diabetes mellitus. However, its precise roles and me
Externí odkaz:
https://doaj.org/article/d73cd3eefbcf410098ed4824a11a69cb
Autor:
Dianbao Zuo, Yuankui Zhu, Ke Wang, Youjia Qin, Yiyi Su, Sina Lan, Yunyi Li, Shuang Dong, Yinming Liang, Mingqian Feng
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116782- (2024)
LAG3 is an inhibitory immune checkpoint expressed on activated T and NK cells. Blocking the interaction of LAG3 with its ligands MHC-II and FGL1 renders T cells improved cytotoxicity to cancer cells. Current study generated a panel of LAG3 monoclonal
Externí odkaz:
https://doaj.org/article/78f6243d35f844769bd6e5093a8a01b6
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 365-377 (2024)
Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer, although it is limited by the low tumor delivery efficacy of anticancer drugs. Bacterial therapy is emerging for cancer treatment due to its high immune stimulat
Externí odkaz:
https://doaj.org/article/17a959d374e344c5a11d9993b2ad0536
Autor:
Yuankui Zhu, Ke Wang, Linghe Yue, Dianbao Zuo, Junfeng Sheng, Sina Lan, Zilong Zhao, Shuang Dong, Sheng Hu, Xin Chen, Mingqian Feng
Publikováno v:
Pharmacological Research, Vol 203, Iss , Pp 107186- (2024)
Chimeric antigen receptor (CAR)-modified T cell therapy has achieved remarkable efficacy in treating hematological malignancies, but it confronts many challenges in treating solid tumors, such as the immunosuppressive microenvironment of the solid tu
Externí odkaz:
https://doaj.org/article/f8665c4783e94d56bf6dd8728ad45a3b
Autor:
Shen Chen, Ke Wang, Hongzhan Wang, Yang Gao, Kexin Nie, Xinyue Jiang, Hao Su, Yueheng Tang, Fuer Lu, Hui Dong, Zhi Wang
Publikováno v:
Pharmacological Research, Vol 201, Iss , Pp 107090- (2024)
Depression is a major global health issue that urgently requires innovative and precise treatment options. In this context, saikosaponin has emerged as a promising candidate, offering a variety of therapeutic benefits that may be effective in combati
Externí odkaz:
https://doaj.org/article/097aeafc679843a99f32dcaef347171c
Autor:
Ke Wang, Pei-Yin Liao, Wei-Chun Chang, Cian-Ru Yang, Yu-Ting Su, Ping-Ching Wu, Yang-Chang Wu, Yao-Ching Hung, Najim Akhtar, Hsueh-Chou Lai, Wen-Lung Ma
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Small molecule compounds targeting multiple kinases involved in neoangiogenesis have shown survival benefits in patients with unresectable hepatocellular carcinoma (HCC). Nonetheless, despite the beneficial effects of multikinase inhibitors (MKIs), a
Externí odkaz:
https://doaj.org/article/c84b74d970bd4b2997ab62852ef8f6df
Autor:
Huixia He, Feifei Lei, Le Huang, Ke Wang, Yaxi Yang, Liu Chen, Yun Peng, Yinming Liang, Huabing Tan, Xiaoyan Wu, Mingqian Feng
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114797- (2023)
Acute and persistent infection of Epstein-Barr virus (EBV) is associated with several life-threatening hematological disorders, including lymphoproliferative disorders (LPD), hemophagocytic lymphohistiocytosis (HLH), and chronic active Epstein-Barr v
Externí odkaz:
https://doaj.org/article/a64d463c2c004b968d027d6c361ea0d3
Autor:
Liuzeng Chen, Ke Wang, Xiaohan Liu, Lifan Wang, Hui Zou, Shuying Hu, Lingling Zhou, Rong Li, Shiying Cao, Banfeng Ruan, Quanren Cui
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractPterostilbene (PST) is a naturally derived stilbene compound in grapes, blueberries, and other fruits. It is also a natural dietary compound with a wide range of biological activities such as antioxidant, anti-inflammatory, antitumor, and so
Externí odkaz:
https://doaj.org/article/e3cacddd22ba408281c0b222a5581728
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113893- (2022)
Compounds containing Michael acceptor units display a wide variety of biological effects, and have attracted much attention in medicinal chemistry. In this paper, we designed and synthesized a panel of para-quinone methides (p-QMs) derivatives, class
Externí odkaz:
https://doaj.org/article/28bd40f70bee4c0b892b44d87cfe66b4