Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Espen Molden"'
Autor:
Espen Molden
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 17:1211-1221
Clozapine (CLZ) is the superior drug in treatment of schizophrenia. Serum concentration of CLZ is associated with clinical response and dose-dependents side effects, where generalized tonic-clonic seizures are most critical. Thus, therapeutic drug mo
Publikováno v:
Clinical pharmacology and therapeutics
The metabolic activity of the polymorphic CYP2D6 enzyme is dependent on the CYP2D6 genotype; however, the guidelines for translating the genotype into phenotype, which are of relevance for adequate drug dose personalization, are ambiguous. In the pre
Publikováno v:
Journal of Clinical Psychopharmacology. 41:281-285
PURPOSE The aim of this study was to investigate the potential dose-dependent CYP2D6 inhibition by bupropion (BUP) in patients with depression. METHODS Patients combining BUP with venlafaxine were included from a therapeutic drug monitoring (TDM) dat
Publikováno v:
European Journal of Clinical Pharmacology. 77:1201-1208
Paliperidone palmitate is an antipsychotic medication available as long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age and gender on paliperidone exposure after administration of LAI formulations. Dat
Publikováno v:
European Journal of Clinical Pharmacology. 77:215-221
Purpose Zuclopenthixol is an antipsychotic available as oral and long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age on zuclopenthixol exposure during oral and LAI administrations without and with adj
Autor:
Roy Miodini Nilsen, Monica Hermann, Susanna M. Wallerstedt, Espen Molden, Kristine Tveit, Ragnhild Birkeland Waade
Publikováno v:
691–701
Drugs & Aging
Drugs & Aging
Background According to previous studies, older patients frequently have serum concentrations of antidepressant medication above the recommended reference range. Objective The aim of this study was to investigate whether prescribed doses of antidepre
Publikováno v:
European Journal of Clinical Pharmacology. 76:41-49
Tailoring medication dosing for the individual patient is complex, and many factors can influence drug exposure. We investigated the effect of age and CYP2D6 genotype on aripiprazole and dehydroaripiprazole exposure in patients using long-acting inje
Publikováno v:
Frederiksen, T, Smith, R L, Wollmann, B M, Areberg, J & Molden, E 2021, ' Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data ', Clinical Pharmacokinetics, vol. 60, no. 11, pp. 1475-1486 . https://doi.org/10.1007/s40262-021-01029-7
Clinical Pharmacokinetics
Clinical Pharmacokinetics
Introduction Vortioxetine is an antidepressant primarily metabolized by the polymorphic enzyme cytochrome P450 (CYP) 2D6. A population pharmacokinetic (popPK) model of vortioxetine and its CYP2D6-dependent metabolite was recently published. Objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c2219e990ad44f794b91b8a588049c
https://findresearcher.sdu.dk:8443/ws/files/194772021/Frederiksen_2021_Validation_of_a_population_pharmaco.pdf
https://findresearcher.sdu.dk:8443/ws/files/194772021/Frederiksen_2021_Validation_of_a_population_pharmaco.pdf
Publikováno v:
Therapeutic Drug Monitoring. 41:396-400
Drugs may potentially adsorb to blood collection tubes containing gel separators in the preanalytical phase of therapeutic drug monitoring. The aim of this study was to compare measured concentrations of 28 psychoactive drugs and 13 metabolites in sp
Autor:
Christoph U. Correll, Marit Tveito, Gudrun Høiseth, Espen Molden, Cecilie B. Hartberg, Robert Løvsletten Smith, Tore Haslemo, Helge Refsum
Publikováno v:
Journal of Clinical Psychopharmacology. 38:570-576
PURPOSE Olanzapine is a commonly prescribed antipsychotic available as oral and long-acting injectable (LAI) formulations. Data are lacking on the use and safety of olanzapine-LAI in older patients. The aim of this study was to investigate the effect