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pro vyhledávání: '"Olmos-Alonso A"'
Autor:
De Lucia, Chiara, Rinchon, Adeline, Olmos-Alonso, Adrian, Riecken, Kristoffer, Fehse, Boris, Boche, Delphine, Perry, V. Hugh, Gomez-Nicola, Diego
Publikováno v:
Brain, Behavior, and Immunity. 55:179-190
Neurogenesis is altered in neurodegenerative disorders, partly regulated by inflammatory factors. We have investigated whether microglia, the innate immune brain cells, regulate hippocampal neurogenesis in neurodegeneration. Using the ME7 model of pr
Autor:
Chiara, De Lucia, Adeline, Rinchon, Adrian, Olmos-Alonso, Kristoffer, Riecken, Boris, Fehse, Delphine, Boche, V Hugh, Perry, Diego, Gomez-Nicola
Publikováno v:
Brain, Behavior, and Immunity
Highlights • Microglia are proneurogenic in a model of prion disease. • Blocking the expansion of microglia prevents the aberrant differentiation of newborn neurons. • TGFβ dominates the proneurogenic actions of microglia during chronic neurod