Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Asla Pitkänen"'
Autor:
Anagha Thakur, Barbara Favier, Stefanie Dedeurwaerdere, Koen Augustyns, Jeroen Van Soom, Annemie Van Eetveldt, Lore M. Peeters, Jurgen Joossens, Stephan Missault, Halima Amhaoul, Asla Pitkänen, Steven Staelens, David Thomae
Publikováno v:
Epilepsia
Objective: Urokinase-type plasminogen activator (uPA) and kallikrein-related peptidase 8 (KLK8) are serine proteases that contribute to extracellular matrix (ECM) remodeling after brain injury. They can be labelled with the novel radiotracer [In-111]
Autor:
Francesco Ferraguti, Ross J. Bland, Francesco Noé, Claudia Balducci, Asla Pitkänen, Annamaria Vezzani, Allan-Hermann Pool, Matthew J. During, Marco Gobbi, Gunther Sperk, Massimo Rizzi, Jari Nissinen
Publikováno v:
Brain. 131:1506-1515
Temporal lobe epilepsy remains amongst the most common and drug refractory of neurological disorders. Gene therapy may provide a realistic therapeutic approach alternative to surgery for intractable focal epilepsies. To test this hypothesis, we appli
Autor:
Asla Pitkänen, Katarzyna Majak
Publikováno v:
International Congress Series. 1301:22-27
Studies on fear conditioning have provided important information that has helped to reveal the basis of mnemonic processing at the structural, cellular and molecular level. Temporal lobe epilepsy (TLE), as a pathological process that leads to damage
Publikováno v:
Experimental Neurology. 205:501-505
Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period to the occurrence of spontaneous seizures. The model is commonly used to investigate mechanisms of epileptogenesis as well as the antiepileptic effects o
Publikováno v:
Epilepsia. 47:479-488
Summary: Purpose: Whether status epilepticus (SE) in early infancy, rather than the underlying illness, leads to temporal lobe neurodegeneration and volume reduction remains controversial. Methods: SE was induced with LiCl-pilocarpine in P12 rats. To
Autor:
Leo Paljärvi, Reetta Kälviäinen, Irina Alafuzoff, Asla Pitkänen, Arto Immonen, Leena Jutila, Matti Vapalahti, Kari Karkola, Terhi J. Pirttilä, Anni Manninen, Jari Nissinen, Esa Mervaala
Publikováno v:
Annals of Neurology. 58:211-223
Human temporal lobe epilepsy (TLE) is associated with cellular alterations (eg, hilar cell death, neurogenesis, and granule cell dispersion) in the dentate gyrus but their underlying molecular mechanism are not known. We previously demonstrated incre
Publikováno v:
Neuroscience. 124:269-281
The functional consequences of neuronal loss during epileptogenesis in the lateral and basal amygdaloid nuclei are poorly understood. The present study tested the hypothesis that electrical responsiveness varies in different amygdaloid nuclei in the
Publikováno v:
European Journal of Neuroscience. 17:271-279
Symptomatic temporal lobe epilepsy typically develops in three phases: brain insult --> latency period (epileptogenesis) --> recurrent seizures (epilepsy). We hypothesized that remodeling of neuronal circuits underlying epilepsy is associated with al
Autor:
Asla Pitkänen
Publikováno v:
Epilepsy Research. 50:141-160
Results of experiments performed in animal epilepsy models and human epilepsy during the past decade indicate that the epileptic brain is not a stable neuronal network, but undergoes modifications caused by the underlying etiology and/or recurrent se
Publikováno v:
Hippocampus. 12:735-755
The posterior cortical nucleus of the amygdala is involved in the processing of pheromonal information and presumably participates in ingestive, defensive, and reproductive behaviors as a part of the vomeronasal amygdala. Recent studies suggest that