Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Zakharenko, A"'
Autor:
Oksana V. Salomatina, Tatyana E. Kornienko, Alexandra L. Zakharenko, Nina I. Komarova, Chigozie Achara, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho
Publikováno v:
Molecules, Vol 29, Iss 3, p 581 (2024)
Deoxycholic acid derivatives containing various heterocyclic functional groups at C-3 on the steroid scaffold were designed and synthesized as promising dual tyrosyl-DNA phosphodiesterase 1 and 2 (TDP1 and TDP2) inhibitors, which are potential target
Externí odkaz:
https://doaj.org/article/f7a6940d786f428597863fdfcc30635e
Akademický článek
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Autor:
Chepanova, A. A.1 (AUTHOR), Zakharenko, A. L.1 (AUTHOR), Dyrkheeva, N. S.1 (AUTHOR), Chernyshova, I. A.1 (AUTHOR), Zakharova, O. D.1 (AUTHOR), Ilina, E. S.1 (AUTHOR), Luzina, O. A.2 (AUTHOR), Salakhutdinov, N. F.2 (AUTHOR), Lavrik, O. I.1 (AUTHOR) lavrik@niboch.nsc.ru
Publikováno v:
Doklady Biochemistry & Biophysics. Feb2023, Vol. 508 Issue 1, p25-30. 6p.
Autor:
Chernyshova, Irina A.1 (AUTHOR), Zakharenko, Aleksandra L.1 (AUTHOR), Kurochkin, Nikolay N.2 (AUTHOR), Dyrkheeva, Nadezhda S.1 (AUTHOR), Kornienko, Tatyana E.1 (AUTHOR), Popova, Nelly A.3,4 (AUTHOR), Nikolin, Valeriy P.3 (AUTHOR), Ilina, Ekaterina S.1,4 (AUTHOR), Zharkov, Timofey D.1 (AUTHOR), Kupryushkin, Maxim S.1 (AUTHOR), Oslovsky, Vladimir E.2 (AUTHOR), Drenichev, Mikhail S.2 (AUTHOR), Lavrik, Olga I.1,4 (AUTHOR) lavrik@niboch.nsc.ru
Publikováno v:
Molecules. Jan2023, Vol. 28 Issue 1, p323. 20p.
Autor:
Irina A. Chernyshova, Aleksandra L. Zakharenko, Nikolay N. Kurochkin, Nadezhda S. Dyrkheeva, Tatyana E. Kornienko, Nelly A. Popova, Valeriy P. Nikolin, Ekaterina S. Ilina, Timofey D. Zharkov, Maxim S. Kupryushkin, Vladimir E. Oslovsky, Mikhail S. Drenichev, Olga I. Lavrik
Publikováno v:
Molecules, Vol 28, Iss 1, p 323 (2022)
The use of cancer chemotherapy sensitizers is a promising approach to induce the effect of clinically used anticancer treatments. One of the interesting targets is Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), a DNA-repair enzyme, that may prevent the acti
Externí odkaz:
https://doaj.org/article/1bed77c2f7a94878b8b6b1122def7fc2
Autor:
Oksana V. Salomatina, Nadezhda S. Dyrkheeva, Irina I. Popadyuk, Alexandra L. Zakharenko, Ekaterina S. Ilina, Nina I. Komarova, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho
Publikováno v:
Molecules, Vol 27, Iss 1, p 72 (2021)
A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and 2 (TDP2) enzymes. In addition, 1,2,4- and 1,3,4-oxadiazole derivatives were synthesized to
Externí odkaz:
https://doaj.org/article/c64eb3aa47244fa6bcc807412f459bfb
Autor:
Anastasia O. Komarova, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Irina V. Kulikova, Vladimir E. Oslovsky, Olga D. Zakharova, Alexandra L. Zakharenko, Sergey N. Mikhailov, Olga I. Lavrik
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1415-1429 (2018)
A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors based on disaccharide nucleosides was identified. TDP1 plays an essential role in the resistance of cancer cells to currently used antitumour drugs based on Top1 inhibitors such as topo
Externí odkaz:
https://doaj.org/article/7e913c6c387b42bb8c2b1be76f61b1aa
Autor:
Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Kristina A. Orlova, Irina A. Chernyshova, Tatyana E. Kornienko, Anastasia A. Malakhova, Sergey P. Medvedev, Alexandra L. Zakharenko, Ekaterina S. Ilina, Rashid O. Anarbaev, Konstantin N. Naumenko, Kristina V. Klabenkova, Ekaterina A. Burakova, Dmitry A. Stetsenko, Suren M. Zakian, Nariman F. Salakhutdinov, Olga I. Lavrik
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11336 (2021)
Tyrosyl-DNA phosphodiesterase 1 (TDP1) catalyzes the cleavage of the phosphodiester bond between the tyrosine residue of topoisomerase 1 (TOP1) and the 3′ phosphate of DNA in the single-strand break generated by TOP1. TDP1 promotes the cleavage of
Externí odkaz:
https://doaj.org/article/ffbea489293848d98465c39d785114bf
Akademický článek
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Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.