Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yuqiong Liang"'
Publikováno v:
Nat Immunol
Maintenance of tissue homeostasis is dependent on the communication between stem cells and supporting cells in the same niche. Regulatory T cells (Treg) are a critical component of the stem cell niche to support their differentiation. How Treg cells
Autor:
Jovylyn Gatchalian, Chin-San Loo, Bhargav Venkatraghavan, Yuqiong Liang, Josephine Ho, Ye Zheng, Diana C. Hargreaves, Mingjun Xie, Mathias Leblanc
Publikováno v:
Immunity
Summary Regulatory T (Treg) cells play a pivotal role in suppressing auto-reactive T cells and maintaining immune homeostasis. Treg cell development and function are dependent on the transcription factor Foxp3. Here, we performed a genome-wide CRISPR
Autor:
Mathias Leblanc, Christopher Liddle, Ronald M. Evans, Annette R. Atkins, Ruth T. Yu, Jae Myoung Suh, Yuqiong Liang, Ye Zheng, Michael Downes, Sihao Liu, Carmen Zhou, Sungsoon Fang, Yang Zhang, Albert Cheng, Sagar P. Bapat
Publikováno v:
Nature. 528:137-141
Age-associated insulin resistance (IR) and obesity-associated IR are two physiologically distinct forms of adult-onset diabetes. While macrophage-driven inflammation is a core driver of obesity-associated IR, the underlying mechanisms of the obesity-
Autor:
Chan-Wang J. Lio, Chyi-Song Hsieh, Jingqin Luo, Stephanie K. Lathrop, Katherine A. Forbush, Jhoanne L. Bautista, Yuqiong Liang, Alexander Y. Rudensky
Publikováno v:
Nature Immunology. 10:610-617
Because the deletion of self-reactive T cells is incomplete, thymic development of natural Foxp3+CD4+ regulatory T cells (Treg cells) is required for preventing autoimmunity. However, the function of T cell antigen receptor (TCR) specificity in thymi
Publikováno v:
Nature Immunology. 7:401-410
The relationship between the T cell receptor (TCR) repertoires used by self-reactive transcription factor Foxp3-positive (Foxp3(+)) CD4(+) regulatory T cells (T(reg) cells) and nonregulatory T cells with autoimmune potential is unclear. Here we found
Publikováno v:
Cell. 158(4)
SummaryThe homeostasis of multicellular organisms requires terminally differentiated cells to preserve their lineage specificity. However, it is unclear whether mechanisms exist to actively protect cell identity in response to environmental cues that
Autor:
Arnold Kas, Alexander Y. Rudensky, Yuqiong Liang, Piper M. Treuting, Robert M. Samstein, Dipayan Rudra, Ashutosh Chaudhry
Publikováno v:
Science (New York, N.Y.). 326(5955)
Outfoxing Immune Excess Immune responses are kept in check by Foxp3-expressing CD4 + -regulatory T cells (T regs ) through a variety of mechanisms. Expression of specific transcription factors directs T reg responses into distinct T helper cell linea