Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Justin Eyquem"'
Autor:
Sjoukje J. C. van der Stegen, Pieter L. Lindenbergh, Roseanna M. Petrovic, Hongyao Xie, Mame P. Diop, Vera Alexeeva, Yuzhe Shi, Jorge Mansilla-Soto, Mohamad Hamieh, Justin Eyquem, Annalisa Cabriolu, Xiuyan Wang, Ramzey Abujarour, Tom Lee, Raedun Clarke, Bahram Valamehr, Maria Themeli, Isabelle Riviere, Michel Sadelain
Publikováno v:
van der Stegen, S J C, Lindenbergh, P L, Petrovic, R M, Xie, H, Diop, M P, Alexeeva, V, Shi, Y, Mansilla-Soto, J, Hamieh, M, Eyquem, J, Cabriolu, A, Wang, X, Abujarour, R, Lee, T, Clarke, R, Valamehr, B, Themeli, M, Riviere, I & Sadelain, M 2022, ' Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells ', Nature Biomedical Engineering, vol. 6, no. 11, pp. 1284-1297 . https://doi.org/10.1038/s41551-022-00915-0
Nature Biomedical Engineering, 6(11), 1284-1297. Nature Publishing Group
Nat Biomed Eng
Nature Biomedical Engineering, 6(11), 1284-1297. Nature Publishing Group
Nat Biomed Eng
The production of autologous T cells expressing a chimaeric antigen receptor (CAR) is time-consuming, costly and occasionally unsuccessful. T-cell-derived induced pluripotent stem cells (TiPS) are a promising source for the generation of ‘off-the-s
Autor:
Dana V. Foss, Joseph J. Muldoon, David N. Nguyen, Daniel Carr, Srishti U. Sahu, John M. Hunsinger, Stacia K. Wyman, Netravathi Krishnappa, Rima Mendonsa, Elaine V. Schanzer, Brian R. Shy, Vivasvan S. Vykunta, Vincent Allain, Zhongmei Li, Alexander Marson, Justin Eyquem, Ross C. Wilson
Publikováno v:
Nature biomedical engineering, vol 7, iss 5
CRISPR-mediated genome editing of primary human lymphocytes is typically carried out via electroporation, which can be cytotoxic, cumbersome and costly. Here we show that the yields of edited primary human lymphocytes can be increased substantially b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d98d71ebdbd567262a88ba896fa4ca
https://escholarship.org/uc/item/0d8552gt
https://escholarship.org/uc/item/0d8552gt
Autor:
Daniel B. Goodman, Camillia S. Azimi, Kendall Kearns, Alexis Talbot, Kiavash Garakani, Julie Garcia, Nisarg Patel, Byungjin Hwang, David Lee, Emily Park, Vivasvan S. Vykunta, Brian R. Shy, Chun Jimmie Ye, Justin Eyquem, Alexander Marson, Jeffrey A. Bluestone, Kole T. Roybal
Publikováno v:
Science translational medicine, vol 14, iss 670
Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T cells to refractory cancers but have shown limited efficacy in persistent, recurrent malignancies. Here, we introduce “CAR Pooling,” a multiplexed approach to
Autor:
Julia Carnevale, Eric Shifrut, Nupura Kale, William A. Nyberg, Franziska Blaeschke, Yan Yi Chen, Zhongmei Li, Sagar P. Bapat, Morgan E. Diolaiti, Patrick O’Leary, Shane Vedova, Julia Belk, Bence Daniel, Theodore L. Roth, Stefanie Bachl, Alejandro Allo Anido, Brooke Prinzing, Jorge Ibañez-Vega, Shannon Lange, Dalia Haydar, Marie Luetke-Eversloh, Maelys Born-Bony, Bindu Hegde, Scott Kogan, Tobias Feuchtinger, Hideho Okada, Ansuman T. Satpathy, Kevin Shannon, Stephen Gottschalk, Justin Eyquem, Giedre Krenciute, Alan Ashworth, Alexander Marson
Publikováno v:
Nature, vol 609, iss 7925
The efficacy of adoptive T cell therapies for cancer treatment can be limited by suppressive signals from both extrinsic factors and intrinsic inhibitory checkpoints1,2. Targeted gene editing has the potential to overcome these limitations and enhanc
Autor:
Yannick D. Muller, Duy P. Nguyen, Leonardo M. R. Ferreira, Patrick Ho, Caroline Raffin, Roxxana Valeria Beltran Valencia, Zion Congrave-Wilson, Theodore L. Roth, Justin Eyquem, Frederic Van Gool, Alexander Marson, Laurent Perez, James A. Wells, Jeffrey A. Bluestone, Qizhi Tang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in immunology, vol. 12, pp. 639818
Frontiers in Immunology
Frontiers in immunology, vol. 12, pp. 639818
Frontiers in Immunology
Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the extracellular antigen-targeting CARs and the intracellula
Autor:
Michel Sadelain, Jie Sun, Judith Feucht, Annalisa Cabriolu, Josef Leibold, Anton Dobrin, Zeguo Zhao, Yu-Jui Ho, Justin Eyquem, Mohamad Hamieh
Publikováno v:
Nature Medicine. 25:82-88
Chimeric antigen receptors (CARs) are synthetic receptors that target and reprogram T cells to acquire augmented antitumor properties1. CD19-specific CARs that comprise CD28 and CD3ζ signaling motifs2 have induced remarkable responses in patients wi
Autor:
Michel Sadelain, Sjoukje J. C. van der Stegen, Mithat Gonen, Mohamad Hamieh, Theodoros Giavridis, Ashlesha Odak, Jorge Mansilla-Soto, Justin Eyquem, Kristen M. Cunanan
Publikováno v:
Nature. 543:113-117
Chimeric antigen receptors (CARs) are synthetic receptors that redirect and reprogram T cells to mediate tumour rejection. The most successful CARs used to date are those targeting CD19 (ref. 2), which offer the prospect of complete remission in pati
Autor:
Justin Eyquem, Steven M. Larson, Simone Krebs, Thomas Reiner, Meghan Bell, Christian Brand, Stephen Gottschalk, Afruja Ahad, Vladimir Ponomarev, Michel Sadelain, Wolfgang A. Weber, Lukas M. Carter, Claude F. Meares
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 59(12)
There remains an urgent need for the noninvasive tracking of transfused chimeric antigen receptor (CAR) T cells to determine their biodistribution, viability, expansion, and antitumor functionality. DOTA antibody reporter 1 (DAbR1) comprises a single
Autor:
Fabiana Perna, Cameron Brennan, Mohamad Hamieh, Rajesh K. Soni, Ronald C. Hendrickson, Samuel H. Berman, Michel Sadelain, Justin Eyquem, Jorge Mansilla-Soto
Publikováno v:
Cancer cell. 32(4)
Summary Chimeric antigen receptor (CAR) therapy targeting CD19 has yielded remarkable outcomes in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute myeloid leukemia (AML), we probed the AML surfaceome for overexpr
Autor:
Gordon Weng-Kit Cheung, Agnès Gouble, Sophie Derniame, Roman Galetto, Justin Eyquem, Brian Philip, Cécile Schiffer-Mannioui, Pierrick Potrel, Julianne Smith, Karl S. Peggs, Aymeric Duclert, Cécile Bas, Andrew M. Scharenberg, Laetitia Lemaire, Martin Pule, Diane Le Clerre, Céline Lebuhotel, Sylvain Arnould, Laurent Poirot, Isabelle Chion-Sotinel
Publikováno v:
Cancer research. 75(18)
Adoptive immunotherapy using autologous T cells endowed with chimeric antigen receptors (CAR) has emerged as a powerful means of treating cancer. However, a limitation of this approach is that autologous CAR T cells must be generated on a custom-made