Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jairo Matthews"'
Autor:
Kunal Rai, Jairo Matthews, Linghua Wang, Naval Daver, Zoe Alaniz, Feng Wang, Katarzyna Tomczak, Guillermo Garcia-Manero, Jianhua Zhang, Jin Seon Im, Padmanee Sharma, Gheath Alatrash, Maomao Ding, Jing Ning, Praveen Barrodia, Dapeng Hao, Latasha Little, Koichi Takahashi, Ruiping Wang, Wei Wang, Sreyashi Basu, Patrick K. Reville, Hussein A. Abbas, James P. Allison, Marina Konopleva, Steven M. Kornblau, Michael R. Green, Andrew Futreal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Allogeneic stem cell transplantation can cure relapsed/refractor (R/R) AML via grafted T cells versus leukemia effect, but not a viable option to many patients. By combining azacitidine with nivolumab, we harnessed T cell activity and demo
Single-Cell Deconvolution Identifies T-Cell Correlates of Response to PD-1 Blockade Treatment in AML
Autor:
Naval Daver, Arash Saeedi, Jay R Adolacion, Sreyashi Basu, Mansour Alfayez, Wilmer Flores, Navin Varadarajan, Jairo Matthews, Steven M. Kornblau, Xingyue An
Publikováno v:
Blood. 134:1950-1950
Background The combination of the αPD-1 (nivolumab) and hypomethylating agent azacytidine demonstrated encouraging response rate and overall survival in relapsed/refractory acute myeloid leukemia (AML) patients, compared to azacytidine alone1 (NCT02
Autor:
Ellias Jabbour, Naval Daver, Marina Konopleva, Steven M. Kornblau, Michael Andreeff, Guillermo Garcia-Manero, Brianna Flynn, Jairo Matthews, Sean Mackay, Hagop M. Kantarjian, Mansour Alfayez, Jing Zhou, Sreyashi Basu
Publikováno v:
Cancer Research. 79:LB-222
Background: The immune status of patients with acute myeloid leukemia (AML) is not fully investigated and predictive biomarkers for immunotherapies are needed. Blockade of PD-1/PD L1 pathways in T cell subsets can exert anti-leukemia responses. We he
Autor:
William G. Wierda, Sreyashi Basu, Hagop M. Kantarjian, Nitin Jain, Francesco C. Stingo, Michael J. Keating, Jorge Blando, Roland L. Bassett, Zeev Estrov, Carlos E. Bueso-Ramos, Tapan M. Kadia, Wilmer Flores, Jan A. Burger, Jairo Matthews, Beenu Thakral, Philip A. Thompson, Naval Daver, Padmanee Sharma, James P. Allison, Narmeen Somani, Alessandra Ferrajoli
Publikováno v:
Blood. 128:2012-2012
Background: Limited data is available on expression levels of checkpoint receptors, respective ligands, and other immune markers in patients with CLL (Ramsay et al. Blood 2012). Checkpoint blockade has been a successful therapy of many cancers includ
Autor:
Carlos E. Bueso-Ramos, Michael Andreeff, Steven M. Kornblau, William G. Wierda, James P. Allison, Tapan M. Kadia, Srdan Verstovsek, Jairo Matthews, Naval Daver, Nitin Jain, Narmeen Somani, Hagop M. Kantarjian, Padmanee Sharma, Jorge E. Cortes, Marina Konopleva, Hui Yang, Gautam Borthakur, Guillermo Garcia-Manero, Peter P. Ruvolo, Wilmer Flores, Jorge Blando, Farhad Ravandi, Sreyashi Basu
Publikováno v:
Cancer Research. 76:3205-3205
Introduction: The expression of co-stimulatory (costim) receptors/ligands in the bone marrow (BM) and peripheral blood (PB) in patients (pts) with AML has not been defined. Identification of immune-checkpoint pathways that dominate in AML will guide