Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Glenn Dranoff"'
Autor:
Xiuyu Cui, Amber J. Giles, Christina Jackson, Tanner M. Johanns, Luis Sanchez-Perez, Karolina Woroniecka, Kristen E. Rhodin, Gavin P. Dunn, Hanna Kemeny, Vidyalakshmi Chandramohan, Patrick Healy, S. Harrison Farber, Glenn Dranoff, Aladine A. Elsamadicy, Shohei Koyama, Kent J. Weinhold, Pakawat Chongsathidkiet, Darell D. Bigner, Cosette Dechant, Yen-Rei A. Yu, Landon J. Hansen, Peter E. Fecci
Publikováno v:
Clinical Cancer Research. 24:4175-4186
Purpose: T-cell dysfunction is a hallmark of glioblastoma (GBM). Although anergy and tolerance have been well characterized, T-cell exhaustion remains relatively unexplored. Exhaustion, characterized in part by the upregulation of multiple immune che
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
Autor:
Karolina Woroniecka, Jeffrey I. Everitt, Peter E. Fecci, Hanna Kemeny, Robert L. Martuza, John H. Sampson, James E. Herndon, Tooba A. Cheema, Christina Jackson, William T. Curry, Pakawat Chongsathidkiet, Xiuyu Cui, Nicholas C. Souders, Cosette Dechant, Brian V. Nahed, Michael D. Gunn, Shohei Koyama, Franziska Loebel, Glenn Dranoff, Jean-Valery Coumans, Aladine A. Elsamadicy, S. Harrison Farber, Luis Sanchez-Perez
Publikováno v:
Nature medicine
T-cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among other defects, T-cell lymphopenia is characteristic, yet often attributed to treatment. We reveal that even trea
Autor:
Lina Driouk, Joanina K. Gicobi, Yusuke Kamihara, Kayleigh Rutherford, Glenn Dranoff, Jerome Ritz, Susanne H. C. Baumeister
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
CAR T cell approaches to effectively target AML and T-ALL without off-tumor effects on healthy myeloid or T cell compartments respectively are an unmet medical need. NKG2D-ligands are a promising target given their absence on healthy cells and surfac
Autor:
Jeffrey A. Engelman, Catherine Anne Sabatos-Peyton, Adam S. Crystal, Scott Cameron, Viviana Cremasco, Sonia Quaratino, Philip Gotwals, Becker Hewes, Glenn Dranoff, Daniela Cipolletta, Britta Mueller, Lilli Petruzzelli
Publikováno v:
Nature Reviews Cancer. 17:286-301
Over the past 25 years, research in cancer therapeutics has largely focused on two distinct lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous, genetic drivers of tumorigenesis have led to the development of clini
Autor:
Venkat S. Malladi, Chad V. Pecot, Sangeetha Palakurthi, Juan J. Miret, Mingrui Zhu, Kwok-Kin Wong, Esra A. Akbay, Wei Huang, Shohei Koyama, Yujiro Naito, William F. Walker, Glenn Dranoff, Yvonne Y. Li, Min Wu, Peter S. Hammerman, Paul Kirschmeier
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Background Tumor orchestrated metabolic changes in the microenvironment limit generation of anti-tumor immune responses. Availability of arginine, a semi-essential amino acid, is critical for lymphocyte proliferation and function. Levels of arginine
Autor:
K. G. Papavinasasundaram, Alissa C. Rothchild, Cláudio Nunes-Alves, Xinchun Chen, Girija Goyal, Qianting Yang, Christopher M. Sassetti, Samuel M. Behar, Jinhee Lee, Britni L. Stowell, Glenn Dranoff
Publikováno v:
mBio
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e01514-17 (2017)
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e01514-17 (2017)
Mice deficient for granulocyte-macrophage colony-stimulating factor (GM-CSF−/−) are highly susceptible to infection with Mycobacterium tuberculosis, and clinical data have shown that anti-GM-CSF neutralizing antibodies can lead to increased susce
Autor:
Andrew J. Wagner, Stephen A. Allsop, Jerome Ritz, David E. Fisher, David M. Nemer, John M. Goldberg, Catia Fonseca, Suzanne George, Yukoh Nakazaki, F. Stephen Hodi, Gordon J. Freeman, Cecilia Lezcano, Martin C. Mihm, Donna Neuberg, Jeffrey A. Morgan, Glenn Dranoff, Chandrajit P. Raut, George D. Demetri, Christine Canning
Publikováno v:
Clinical Cancer Research. 21:3178-3186
Purpose: Alveolar soft-part sarcoma (ASPS) and clear cell sarcoma (CCS) are rare mesenchymal malignancies driven by chromosomal translocations that activate members of the microphthalmia transcription factor (MITF) family. However, in contrast to mal
Autor:
Glenn Dranoff, Gordon J. Freeman, Margaret Soucheray, Camilla L. Christensen, Matthew D. Wilkerson, Mohit Butaney, Lynette M. Sholl, Andrew D. Cherniack, Esra A. Akbay, D. Neil Hayes, Travis J. Cohoon, Kwok-Kin Wong, Shohei Koyama, Julian Carretero, Oliver Mikse, Peter S. Hammerman, Scott J. Rodig, Jeremy H. Tchaicha, Peter E. Fecci, Jacob B. Reibel, Pasi A. Jänne, Geoffrey I. Shapiro, Matthew Meyerson, Ellen M. Beauchamp, Abigail Altabef, Takeshi Shimamura, Trevor J. Pugh
Publikováno v:
Cancer Discovery. 3:1355-1363
The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between EGF receptor (EGFR) pathway activation and a signature of immun
Autor:
Natalie R. Goldstein, Philippe Armand, Corey Cutler, Jeng-Shin Lee, Richard C. Mulligan, Di Wu, Vincent T. Ho, Ursula Hainz, Ana Brusic, Robert J. Soiffer, Catherine J. Wu, Anselmo Alonso, Jerome Ritz, Mildred Pasek, John Koreth, Jessica Wong, Joseph H. Antin, Ute E. Burkhardt, Edwin P. Alyea, Jennifer R. Brown, Masayasu Naito, Glenn Dranoff, Ann Perrin, Wanyong Zeng, Sean McDonough, Tetsuro Sasada, Christine Canning, Donna Neuberg, Naa Norkor Hammond, Quinlan L. Sievers, Kristen E. Stevenson
Publikováno v:
Journal of Clinical Investigation. 123:3756-3765
Background Patients with advanced hematologic malignancies remain at risk for relapse following reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT). We conducted a prospective clinical trial to test whe
Autor:
Seth Ettenberg, Nicholas S. Wilson, Sarah M. Rue, Maurice Windman, Yannick Bulliard, Jennifer Brogdon, Glenn Dranoff, Rose Jolicoeur, Deborah A. Knee
Publikováno v:
The Journal of Experimental Medicine
Antibodies that coengage activating FcγRs expressed by tumor-associated leukocytes facilitate the selective elimination of intratumoral T cells.
Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target
Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target