Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ernest S. Smith"'
Autor:
John E. Leonard, Elizabeth E. Evans, Marya F. Chaney, Terrence L. Fisher, Maurice Zauderer, Amber Foster, Ernest S. Smith, Crystal Mallow
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundImmunosuppressive myeloid cells in the tumor microenvironment (TME) are a critical limitation to the efficacy of immune checkpoint inhibitors (ICIs) in patients with head and neck squamous cell carcinoma (HNSCC). Both semaphorin 4D (SEMA4D,
Autor:
Brian Olson, Michael C. Lowe, Maurice Zauderer, Desa Rae Pastore, Crystal Mallow, Conor E. Steuer, John E. Leonard, Ernest S. Smith, Elizabeth E. Evans, Gregory B. Lesinski, Nabil F. Saba, Christina Wu, Ragini R. Kudchadkar, Terrence L. Fisher
Publikováno v:
Cancer Research. 79:CT016-CT016
Interrogation of the tumor microenvironment (TME) is crucial to provide insight into biological activity, resistance mechanisms and implementation of rational combination immunotherapies. Semaphorin 4D (SEMA4D, CD100) has broad immunomodulatory effec
Autor:
Conor E. Steuer, Elizabeth E. Evans, Gregory B. Lesinski, Antoni Ribas, Maria Scrivens, Emily Greengard, Alan Howell, Brian Olson, Paul E. Clavijo, Ernest S. Smith, Siwen Hu-Lieskovan, Terrence L. Fisher, Clint T. Allen, Leslie Balch, Sebold Torno, Christina Wu, Christine Reilly, Maurice Zauderer, Nabil F. Saba, Crystal Mallow, Desa Rae Pastore, John E. Leonard, Holm Bussler
Publikováno v:
Cancer Research. 79:1545-1545
Anti-semaphorin 4D (SEMA4D, CD100) blocking antibody promotes immune infiltration, reduces immunosuppressive myeloid cells, and enhances T cell activity and tumor growth inhibition in combination with various immunotherapies in preclinical animal mod
Publikováno v:
Oral Microbiology and Immunology. 15:181-187
Antigen-specific T-cell clones were obtained from mice immunized with Fusobacterium nucleatum ATCC 10953 and/or Porphyromonas gingivalis 381. 10 BALB/c mice per group were immunized with F. nucleatum followed by P. gingivalis, or with P. gingivalis a
Autor:
Laurie A. Winter, Raymond Watkins, Alan S. Jonason, Jennifer Seils, John E. Leonard, Maurice Zauderer, Terrence L. Fisher, Ernest S. Smith, Chad A. Cornelius
Publikováno v:
Cancer Research. 72:936-936
Vaccinex is developing VX15/2503, a humanized IgG4 anti-Semaphorin 4D (SEMA4D; CD100) antibody with approximately 5 nM affinity, for the treatment of patients with advanced solid tumors and for the treatment of patients with multiple sclerosis. SEMA4
Autor:
Jennifer Seils, Terrence L. Fisher, Alan S. Jonason, Ernest S. Smith, Christine Reilly, Laurie A. Winter, Raymond Watkins, John E. Leonard, Chad A. Cornelius, Maurice Zauderer
Publikováno v:
Cancer Research. 71:4578-4578
VX15/2503 is a humanized IgG4 monoclonal antibody that binds with approximately 3 nM affinity to Semaphorin 4D (SEMA4D, CD100). SEMA4D is an important mediator of axonal growth cone guidance, vascular development, angiogenesis, and T cell and B cell