Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Doron Merkler"'
Autor:
Raphael Kuhn, Ioana Sandu, Andreas Agrafiotis, Kai-Lin Hong, Danielle Shlesinger, Daniel Neimeier, Doron Merkler, Annette Oxenius, Sai T. Reddy, Alexander Yermanos
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
CD8+ T cells play a crucial role in the control and resolution of viral infections and can adopt a wide range of phenotypes and effector functions depending on the inflammatory context and the duration and extent of antigen exposure. Similarly, viral
Externí odkaz:
https://doaj.org/article/3fe6fda7adbd4b97a8c9ea15e226f3d6
In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell–Mediated Host Surveillance
Autor:
Ben J. Nichols, Nora Ruef, Nicolas Page, Guerric P. B. Samson, Verena Niggli, Jens V. Stein, Daniel F. Legler, Xenia Ficht, Federica Moalli, Doron Merkler, Alba Diz-Muñoz, Bettina Stolp
Publikováno v:
Journal of Immunology, Vol. 203, No 9 (2019) pp. 2377-2387
Flotillin-1 (Flot1) is an evolutionary conserved, ubiquitously expressed lipid raft–associated scaffolding protein. Migration of Flot1-deficient neutrophils is impaired because of a decrease in myosin II–mediated contractility. Flot1 also accumul
Autor:
Thomas Gruber, Nicolas Page, Aaron J. Johnson, Armelle Klopstein, Vivianne M. Schallenberg, Javier R. Pareja, Urban Deutsch, Sidar Aydin, Elisa Kaba, Britta Engelhardt, Doron Merkler, Mirjam Schenk
Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+T cells are found in MS lesions and antigen (Ag)-presentation at the BBB was pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::846ca216210c4b2599834376fd42c3b6
https://doi.org/10.1101/2021.10.12.464035
https://doi.org/10.1101/2021.10.12.464035
Autor:
Sai T. Reddy, Raphael Kuhn, Annette Oxenius, Andreas Agrafiotis, Kai-Lin Hong, Doron Merkler, Alexander Yermanos, Ioana Sandu, Daniel Neumeier
Publikováno v:
Frontiers in Immunology, 13
CD8+ T cells play a crucial role in the control and resolution of viral infections and can adopt a wide range of phenotypes and effector functions depending on the inflammatory context and the duration and extent of antigen exposure. Similarly, viral
Autor:
Ingrid Wagner, Giovanni Di Liberto, Doron Merkler, Bogna Klimek, Jonathan Kaye, Nicolas Page, Alexandre Mariotte, Sylvain Lemeille, Ilena Vincenti
Publikováno v:
Nature Communications, Vol. 12, No 1 (2021) P. 1009
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Self-reactive CD8+ T cells are important mediators of progressive tissue damage in autoimmune diseases, but the molecular program underlying these cells’ functional adaptation is unclear. Here we characterize the transcriptional and epigenetic land
Autor:
Ingrid Wagner, Dirk H. Busch, Giovanni Di Liberto, Simon P. Fräßle, Sarah Dötsch, Thomas Korn, Christopher Sie, Doron Merkler, Benjamin Knier, Meike Mitsdoerffer, Lilian Aly, Mario Kreutzfeldt, Monika Pfaller
Publikováno v:
Brain (2021)
Brain
Brain
Meningeal B lymphocyte aggregates have been described in autopsy material of patients with chronic multiple sclerosis. The presence of meningeal B cell aggregates has been correlated with worse disease. However, the functional role of these meningeal
Autor:
Mario Kreutzfeldt, Melanie Greter, Doron Merkler, Ingrid Wagner, Noushin Hadadi, Ilena Vincenti, Mary-Aude Rochat, Martina Spiljar, Nicolas Page, Mirko Trajkovski, Ozren Stojanović, Matthias Mack, Bogna Klimek, Dilay Cansever, Claire Chevalier, Nicolas Suárez-Zamorano, Dorothée Rigo, Karin Steinbach
SUMMARYAutoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6Chi monocytes are key effectors in CNS autoimmunity with elusive role in priming naïve autoreactive T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d4bc2a547c16771095b00097357fbad
https://doi.org/10.1101/2020.08.28.269563
https://doi.org/10.1101/2020.08.28.269563
Autor:
Federica Moalli, U. Valentin Nägerl, Christoph Schlapbach, Bettina Stolp, Philipp Germann, Oliver T. Fackler, Nicolas Page, Kirsten A. Keyser, Flavian Thelen, Lukas M. Altenburger, Matthias S. Dettmer, James Sharpe, Doron Merkler, S. Morteza Seyed Jafari, Xenia Ficht, Andrea Raimondi, Jens V. Stein, V. V. G. Krishna Inavalli, Nora Ruef, Matteo Iannacone, Francesca Barone
Publikováno v:
Science Immunology, Vol. 5, No 46 (2020) P. eaaz4371
It is well established that tissue macrophages and tissue-resident memory CD8+ T cells (TRM) play important roles for pathogen sensing and rapid protection of barrier tissues. In contrast, the mechanisms by which these two cell types cooperate for ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1038eff2b8c89f6e7956eea98a55f48f
http://doc.rero.ch/record/328393/files/ste_sgm.pdf
http://doc.rero.ch/record/328393/files/ste_sgm.pdf
In vivo function of the lipid raft protein Flotillin 1 during CD8+ T cell-mediated host surveillance
Autor:
Federica Moalli, Doron Merkler, Nora Ruef, Bettina Stolp, Nicolas Page, Xenia Ficht, Alba Diz-Muñoz, Verena Niggli, Jens V. Stein, Ben J. Nichols
Flotillin-1 (Flot1) is a highly conserved, ubiquitously expressed lipid raft-associated scaffolding protein. Migration of Flot1-deficient neutrophils is impaired due to a decrease in myosin II-mediated contractility. Flot1 also accumulates in the uro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca731df683f0fbb90c9b0d2918157eaa
https://doi.org/10.1101/403592
https://doi.org/10.1101/403592
Autor:
Mykhailo Vladymyrov, Ruth Lyck, Michael Sixt, Xenia Ficht, Alba Diz-Muñoz, Jasmin Balmer, Martin Bähler, Ingrid de Vries, Bettina Stolp, Matteo Iannacone, Jens V. Stein, Federica Moalli, Amleto Fiocchi, Doron Merkler, Michael Hubert Stoffel, Mario Kreutzfeldt, Akitaka Ariga, James Sharpe, Philipp Germann
Publikováno v:
Moalli, Federica; Ficht, Xenia; Germann, Philipp; Vladymyrov, Mykhailo; Stolp, Bettina; de Vries, Ingrid; Lyck, Ruth; Balmer, Jasmin Maria; Fiocchi, Amleto; Kreutzfeldt, Mario; Merkler, Doron; Iannacone, Matteo; Ariga, Akitaka; Stoffel, Michael Hubert; Sharpe, James; Bähler, Martin; Sixt, Michael; Diz-Muñoz, Alba; Stein, Jens Volker (2018). The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 T cells. Journal of experimental medicine, 215(7), pp. 1869-1890. Rockefeller University Press 10.1084/jem.20170896
The Journal of Experimental Medicine
Journal of Experimental Medicine, Vol. 215, No 7 (2018) pp. 1869-1890
The Journal of Experimental Medicine
Journal of Experimental Medicine, Vol. 215, No 7 (2018) pp. 1869-1890
Moalli et al. combine in vitro CD8+ T cell motility analysis with intravital imaging of mouse tissues to identify the actomyosin regulator Myo9b as a central player for nonlymphoid tissue infiltration during adaptive immune responses by facilitating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4de5cecfa49254e0fcb9a44b1977e9
https://boris.unibe.ch/117340/1/jem.20170896.full.pdf
https://boris.unibe.ch/117340/1/jem.20170896.full.pdf