Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Prasada Rao S. Kodavanti"'
Publikováno v:
Toxicology and Applied Pharmacology. 162:10-21
ortho-Substituted polychlorinated biphenyls (PCBs) make up a large part of the PCB residue found in the environment and human tissues. Our laboratory as well as others have demonstrated that ortho-substituted congeners exhibit important biological ac
Publikováno v:
Toxicology. 136:27-39
Recent studies from the laboratory indicate that polychlorinated biphenyl (PCB) congeners can alter signal transduction and calcium homeostasis in neuronal preparations. These effects were more pronounced for the ortho -substituted, non-coplanar cong
Publikováno v:
Toxicology Letters. :631-635
Despite a ban on their manufacture in 1977, polychlorinated biphenyls (PCBs) are still found in significant quantities in the environment. Developmental exposure to PCBs and related compounds has been reported to be neurotoxic in human and animals. R
Autor:
Prasada Rao S. Kodavanti, Patricia E. Ganey, Isaac N. Pessah, Richard F. Seegal, Lawrence J. Fischer
Publikováno v:
Toxicological Sciences. 41:49-61
Research into the mechanism of toxicity of PCBs has focused on the Ah receptor. However, it is becoming increasingly clear that certain ortho-chlorine-substituted, non-coplanar PCB congeners having low affinity for the Ah receptor exhibit important b
Publikováno v:
Toxicology and Applied Pharmacology. 138:251-261
Our previous reports indicate that ortho-substituted non-coplanar polychlorinated biphenyl (PCB) congeners perturbed neuronal Ca2+-homeostasis in vitro, altered agonist-stimulated inositol phosphate accumulation, and caused protein kinase C (PKC) tra
Publikováno v:
Archives of Toxicology. 70:150-157
Recent studies from our laboratory indicate that polychlorinated biphenyl (PCB) congeners in vitro perturbed signal transduction mechanisms including cellular Ca2+-homeostasis and protein kinase C translocation. We have now investigated the structure
Publikováno v:
Journal of Applied Toxicology. 14:225-229
Polychlorinated biphenyl (PCBs) mixtures contain a number of different congeners, some of which have been proposed to be neuroactive. Recent studies have suggested that ortho-substituted PCBs may be neuroactive, while 'dioxin-like' non-ortho-substitu
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 98(1)
The neuropeptide, vasopressin (VP) is synthesized in magnocellular neuroendocrine cells (MNCs) located within the supraoptic (SON) and paraventricular (PVN) nuclei of the mammalian hypothalamus. VP has multiple functions including maintenance of body
Autor:
Linda S. Birnbaum, Larry W. Robertson, Thomas R. Ward, Prasada Rao S. Kodavanti, Gabriele Ludewig
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 88(1)
Polybrominated diphenyl ethers (PBDEs), widely used as flame-retardants, are now recognized as globally distributed pollutants, and are detected in most environmental and biological samples, including human blood, adipose tissue, and breast milk. Due
Autor:
Prasada Rao S. Kodavanti, Thomas R. Ward, Ethel C Derr-Yellin, Hugh A. Tilson, James D. McKinney
Publikováno v:
Neurotoxicology. 24(2)
Our previous structure–activity relationship (SAR) studies indicated that the effects of polychlorinated biphenyls (PCBs) on neuronal Ca2+ homeostasis and protein kinase C (PKC) translocation were associated with the extent of coplanarity. Chlorine