Zobrazeno 1 - 10
of 25
pro vyhledávání: '"M. Kyle Hadden"'
Autor:
Jiachen Wen, M. Kyle Hadden
Publikováno v:
European journal of medicinal chemistry. 228
Vitamin D3 (VD3) is a seco-steroid that inhibits the Hedgehog (Hh) signaling pathway. Initial studies suggested its anti-Hh activity results from direct inhibition of Smoothened, a seven-transmembrane cell surface receptor that is a key regulator of
Publikováno v:
European Journal of Medicinal Chemistry. 162:495-506
The Hedgehog (Hh) pathway is a developmental pathway with therapeutic potential as a target for a variety of cancers. In recent years, several vitamin D-based compounds have been identified as potent inhibitors of Hh signaling. These analogues contai
Autor:
Radha Charan Dash, Dmitry M. Korzhnev, Irina Bezsonova, Angela M. Zaino, M. Kyle Hadden, Yunfeng Li, Alessandro A. Rizzo, Bing Hao, Kerry Silva McPherson
Publikováno v:
ChemMedChem
Rev1 is a protein scaffold of the translesion synthesis (TLS) pathway, which employs low-fidelity DNA polymerases for replication of damaged DNA. The TLS pathway helps cancers tolerate DNA damage induced by genotoxic chemotherapy, and increases mutag
Autor:
M. Kyle Hadden, Jiachen Wen
Publikováno v:
ChemMedChem. 13:748-753
The Hedgehog (Hh) signaling pathway is critical for embryonic patterning and postembryonic tissue regeneration. Constitutive pathway activation has also been linked to human malignancies such as basal cell carcinoma (BCC) and medulloblastoma; therefo
Publikováno v:
ACS Med Chem Lett
[Image: see text] We conducted a structure–activity relationship study to explore simplified analogues of the itraconazole (ITZ) scaffold for their ability to inhibit the hedgehog (Hh) signaling pathway. These analogues were based on exploring the
Autor:
Angela M. Zaino, Lianne Q. Chau, Robert J. Wechsler-Reya, M. Kyle Hadden, Kelly A. Teske, Jennifer R Pace, Radha Charan Dash
Publikováno v:
J Med Chem
The FDA-approved antifungal agent, itraconazole (ITZ), has been increasingly studied for its novel biological properties. In particular, ITZ inhibits the hedgehog (Hh) signaling pathway and has the potential to serve as an anti-cancer chemotherapeuti
Autor:
Robert J. Wechsler-Reya, Radha Charan Dash, M. Kyle Hadden, Shana R. Morel, Kelly A. Teske, Lianne Q. Chau
Inhibition of the hedgehog (Hh) signaling pathway has been validated as a therapeutic strategy to treat basal cell carcinoma and holds potential for several other forms of human cancer. Itraconazole and posaconazole are clinically useful triazole ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c451bc3f50a49966bf26389d93932b
https://europepmc.org/articles/PMC6358021/
https://europepmc.org/articles/PMC6358021/
Exploring the physicochemical and antiproliferative properties of biaryl-linked [13]-macrodilactones
Autor:
Angela M. Zaino, Cristin Bosko, Mark W. Peczuh, Ryan McLean, M. Kyle Hadden, Chengsheng Chen, Catherine P. McGeough
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115671
A macrocyclic motif fosters productive protein-small molecule interactions. There are numerous examples of both natural product and designed, synthetic macrocycles that modulate the immune system, slow microbial infection, or kill eukaryotic cells. R
Autor:
M. Kyle Hadden, Dmitry M. Korzhnev
Publikováno v:
Journal of Medicinal Chemistry. 59:9321-9336
Human cells possess tightly controlled mechanisms to rescue DNA replication following DNA damage caused by environmental and endogenous carcinogens using a set of low-fidelity translesion synthesis (TLS) DNA polymerases. These polymerases can copy ov
Publikováno v:
ChemMedChem. 11:679-686
Oxysterols (OHCs) are metabolic byproducts of cholesterol that are known to function as agonists of the Hedgehog (Hh) signaling pathway. Previously, we reported 23(S)-hydroxycholesterol [23(S)-OHC, 4] as a potent activator of Hh signaling with the ab