Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Hiroyuki Miyachi"'
Autor:
Minoru Waki, Osamu Ohno, Hiroyuki Miyachi, Osamu Takikawa, Tomomi Sasaki, Akira Asai, Miwa Fukuda, Kenji Matsuno, Tomoko Hashimoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2846-2849
Kynurenine is biosynthesised from tryptophan catalysed by indoleamine 2,3-dioxygenase (IDO). The abrogation of kynurenine production is considered a promising therapeutic target for immunological cancer treatment. In the course of our IDO inhibitor p
Autor:
Hiroyuki Miyachi
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9223, p 9223 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 9223, p 9223 (2021)
Progress in understanding peroxisome proliferator-activated receptor (PPAR) subtypes as nuclear receptors that have pleiotropic effects on biological responses has enabled the exploration of new subtype-selective PPAR ligands. Such ligands are useful
Autor:
Kazuto Nunomura, Kenji Ishimoto, Syohei Fukuda, Takefumi Doi, Keisuke Tachibana, Ryotaro Tabata, Hiroyuki Miyachi, Tomohiro Yuzuriha, Bangzhong Lin, Tadayuki Kobayashi
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(16)
We previously reported that 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivative 6 is an agonist of human peroxisome proliferator-activated receptor alpha (hPPARα). Here, we prepared a series of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid deri
Autor:
Teruo Kuroda, Hiroyuki Miyachi
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 138(12)
We previously showed that a naturally occurring macrocyclic bis(bibenzyl) derivative, riccardin C (RC), exhibits antibacterial activity towards methicillin-resistant Staphylococcus aureus (MRSA), with a potency comparable to that of the clinically us
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2324-2327
Macrocyclic bis(bibenzyl)-type phenolic natural products, found exclusively in bryophytes, exhibit potent antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Here, in order to identify the minimum essentia
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2639-2644
We designed and synthesized acylsulfonamide derivative (3) as a human peroxisome proliferator-activated receptor gamma (hPPARγ) partial agonist by structural modification of hPPARγ full agonist 1. Co-crystallization of 3 with hPPARγ LBD afforded a
Autor:
Minoru Waki, Takuji Oyama, Masao Ohashi, Hiroyuki Miyachi, Yuta Tanaka, Nobuyasu Matsuura, Kenji Matsuno, Hiroaki Tokiwa, Kanae Gamo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4001-4005
We previously reported that a α-benzylphenylpropanoic acid-type hPPARγ-selective agonist with a piperidine ring as the hydrophobic tail part (3) exhibited sub-micromolar-order hPPARγ agonistic activity. In order to enhance the activity, we planned
Autor:
Teruo Kuroda, Hiroaki Tokiwa, Hiroyuki Miyachi, Kenji Matsuno, Hiromi Sawada, Erika Ishitsubo, Daichi Morita, Kenji Onoda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6563-6568
We synthesized a series of macrocyclic bis(bibenzyl) derivatives, including riccardin-, isoplagiochin- and marchantin-class structures, and evaluated their antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity
Autor:
Takuji Oyama, Ken Kataoka, Masao Ohashi, Nam Ho Huh, Masakazu Yashiro, Hiromi Nobusada, Kenji Matsuno, Hiroyuki Miyachi, Tsuyoshi Waku, Kosuke Morikawa, Endy Widya Putranto
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2319-2332
In the continuing study directed toward the development of peroxisome proliferator-activated receptor gamma (hPPARγ) agonist, we attempted to improve the water solubility of our previously developed hPPARγ-selective agonist 3, which is insufficient
Autor:
Miki Okazaki, Kenji Matsuno, Yuichi Hashimoto, Teruo Kuroda, Hiroyuki Miyachi, Daichi Morita, Hiromi Sawada
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7444-7447
Members of a series of macrocyclic bis(bibenzyl) riccardin-class derivatives were found to exhibit antibacterial activity towards methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure–activity relationship (SAR) studies were c