Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Osvaldo Giorgi"'
Autor:
Osvaldo Giorgi, Daniele Lecca, Peter Driscoll, M Orlandi, Rm Escorihuela, Maria Giuseppa Corda
Publikováno v:
Brain Research. 638:133-138
The GABAergic and dopaminergic pathways in the central nervous system (CNS) play a pivotal role in the control of emotions and in the adaptive responses to stressful stimuli. The present study was aimed at characterizing a range of biochemical marker
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 245:139-145
The effects of chronic treatment with the selective dopamine D1 receptor antagonist, SCH 23390, on the steady-state densities and turnover rates of these receptors were investigated in the striatum and substantia nigra of the rat. To this aim, we ass
Publikováno v:
Brain Research. 569:323-329
The steady-state density and the turnover rates of D 1 -dopamine receptors were investigated in the striatum, nucleus accumbens, substantia nigra, and retina of adult (3-month-old) and aged (23-month-old) rats. The turnover rates were measured by mon
Publikováno v:
Journal of Neurochemistry. 57:754-759
The present study was designed to examine the steady-state density and the turnover rates of D1 dopamine (DA) receptors in the striatum, nucleus accumbens, substantia nigra, and retina of the rat. The turnover rates were measured by monitoring the re
Publikováno v:
European journal of pharmacology. 196(2)
SCH 32615 is a novel inhibitor of the enzyme, neutral endopeptidase (NEP, E.C. 3.4.24.11), the so called ‘enkephalinase’, which plays a functional role in the degradation of [Met5]- and [Leu5]enkephalin. The present study was designed to assess w
Publikováno v:
Journal of neural transmission. General section. 82(3)
The effects of age on the binding parameters of the selective D-1 dopamine (DA) receptor antagonist 3H-SCH 23390 were studied in membrane preparations from rat striatum, substantia nigra, olfactory tubercle, prefrontal cortex and retina. When compare
Publikováno v:
European Journal of Pharmacology. 106:427-430
The administration of drugs such as fenfluramine, p-chlorophenylalanine or 5,7-dihydroxytryptamine, which lower brain 5-hydroxytryptamine content, increases the enkephalin content of hypothalamus and striatum. None of these treatmentschanges proenkep
Autor:
G Kirschner, G. Ferrari, Stefano Vicini, D. Benvegnù, M. Favaron, R. Dal Toso, Gino Toffano, D. Presti, Osvaldo Giorgi, C. Soranzo
Publikováno v:
The Journal of Neuroscience. 8:733-745
The use of CNS cultures for detection and quantification of neuronotrophic activity in the CNS has been analyzed. In particular the development, i.e., neurotransmitter uptake characteristics, and survival of dopaminergic and GABAergic neurons in feta
Publikováno v:
Neurobiology of aging. 8(1)
The effects of age on the binding parameters of 3H-SCH 23390, the most selective D-1 dopamine receptor ligand available at present, were studied in membrane preparations from rat striatum. When compared with 3 month old animals, there was a significa
Autor:
G. De Montis, S. Mele, Giovanni Biggio, Maria Luisa Porceddu, L. Cocco, Osvaldo Giorgi, Ennio Ongini
Publikováno v:
Life sciences. 41(6)
Dopamine-sensitive adenylate cyclase and 3H-SCH 23390 binding parameters were measured in the rat substantia nigra and striatum 15 days after the injection of 6-hydroxydopamine into the medial forebrain bundle. The activity of nigral dopamine-sensiti