Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Heewon Lee"'
Autor:
Nelu Grinberg, Jun Wang, Guisheng Li, Jon C. Lorenz, Joe Johnson, Xiufeng Sun, Heewon Lee, Yongda Zhang, Wenjie Li, Joe Gao, Sanjit Sanyal, Zhulin Tan, Nathan K. Yee, Bruce Z. Lu, Keith R. Fandrick, Jiang-Ping Wu, Chris H. Senanayake, Jonathan T. Reeves, Sonia Rodriguez
Publikováno v:
The Journal of Organic Chemistry. 81:2665-2669
An efficient asymmetric synthesis of 11-β-HSD inhibitor 1 has been accomplished in five linear steps and 53% overall yield, starting from the readily available 3-chloro-1-phenylpropan-1-one. The key feature of the synthesis includes an asymmetric me
Autor:
Keith R. Fandrick, Daniel Rivalti, Nizar Haddad, Marisa C. Kozlowski, Olga V. Zatolochnaya, Suttipol Radomkit, Scott Pennino, Nathan K. Yee, Keith McKellop, Dmitry Kurouski, Jean-Nicolas Desrosiers, Heewon Lee, Chris H. Senanayake, Soumik Biswas, Shuklendu D. Karyakarte, Jinhua J. Song, Bo Qu, Sonia Rodriguez, Hari P. R. Mangunuru, Sergei Tcyrulnikov, Joshua D. Sieber
Enantioselective synthesis of α-aryl and α-heteroaryl piperidines is reported. The key step is an iridium-catalyzed asymmetric hydrogenation of substituted N-benzyl pyridinium salts. High levels of enantioselectivity up to 99.3:0.7 er were obtained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea58d5693fceeb4c744ba3de80f4c7e0
https://europepmc.org/articles/PMC5835364/
https://europepmc.org/articles/PMC5835364/
Autor:
Nelu Grinberg, Marc-André Poupart, Jon C. Lorenz, Bo Qu, Nizar Haddad, Nina C. Gonnella, Shengli Ma, Nathan K. Yee, Wenjun Tang, Jiang-Ping Wu, Youla S. Tsantrizos, Wenjie Li, Joe Gao, Kanwar Sidhu, June Wang, Nitinchandra D. Patel, Sonia Rodriguez, Sanjit Sanyal, Heewon Lee, Yongda Zhang, Carl A. Busacca, Diana C. Reeves, Bruce Z. Lu, Keith R. Fandrick, Chris H. Senanayake
Publikováno v:
Angewandte Chemie. 127:7250-7254
A practical and efficient synthesis of a complex chiral atropisomeric HIV integrase inhibitor has been accomplished. The combination of a copper-catalyzed acylation along with the implementation of the BI-DIME ligands for a ligand-controlled Suzuki c
Autor:
Cyrus Ramavarapu, John A. Milligan, Anjan Saha, Zhibin Li, Steven J. Geib, Peter Wipf, Anji Chen, Eakkaphon Rattanangkool, Heewon Lee, Carl A. Busacca, Guijun Wang, Chris H. Senanayake
Publikováno v:
The Journal of Organic Chemistry. 79:9878-9887
The direct addition of anionic secondary phosphine boranes to carbodiimides yields both chiral and achiral phosphaguanidine boranes under ambient temperature conditions. An analogous preparation of menthol-derived phosphinite boranes is also describe
Autor:
Heewon Lee, Rolf Schmid, Nelu Grinberg, Daniel R. Fandrick, Keith R. Fandrick, Jinhua J. Song, Adil Duran, Shengli Ma, Joe Gao, Elizabeth Archer, Nathan K. Yee, Jason A. Mulder, Juergen Daeubler, Carl A. Busacca, Michael Konrad, Nitinchandra D. Patel, Chris H. Senanayake, Frederic G. Buono
Publikováno v:
Organic Letters. 16:4360-4363
A practical noncryogenic process for the Aggarwal stereospecific boronate rearrangement with chiral secondary benzylic carbamates has been developed. The use of LDA instead of sec-BuLi combined with an in situ trapping of the unstable lithiated carba
Autor:
Nathan K. Yee, Sonia Rodriguez, Carl A. Busacca, Shengli Ma, Jolaine Savoie, Bo Qu, Lalith P. Samankumara, Chris H. Senanayake, Nizar Haddad, Daniel R. Fandrick, Heewon Lee, Jinhua J. Song, Xudong Wei
Publikováno v:
The Journal of Organic Chemistry. 79:993-1000
Synthesis of the electron-rich 2-substituted-6-(phenylsulfonyl)pyridines is presented. A series of air-stable, tunable, P-chiral pyridyl-dihydrobenzooxaphosphole ligands were designed and synthesized by a diastereoselective S(N)Ar substitution of the
Autor:
Nitinchandra D. Patel, Xudong Wei, Nizar Haddad, Marisa C. Kozlowski, Jon C. Lorenz, Frank Himmelsbach, Nathan K. Yee, Zhulin Tan, Scot Campbell, Sergei Tcyrulnikov, Jun Wang, Chris H. Senanayake, Jean-Nicolas Desrosiers, Stefan Peters, Xingzhong Zeng, Maurice A. Marsini, Frederic G. Buono, Zhibin Li, Jolaine Savoie, Frank Roschangar, Bing-Shiou Yang, Keith R. Fandrick, Matthias Eckhardt, Heewon Lee, Wenjun Tang, Bo Qu, Jinhua J. Song, Shengli Ma, Osvaldo Gutierrez
Publikováno v:
Journal of the American Chemical Society. 138(47)
A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst loadings. The catalytic enantioselective total synthesis of 1 was accomplished in 7 steps and
Autor:
Michael Spinelli, Jiang-Ping Wu, Austin Gold, Anjan Saha, Chris H. Senanayake, Zhibin Li, Carl A. Busacca, Nizar Haddad, Elisa Farber, Bo Qu, Nicole Grět, Shengli Ma, Nelu Grinberg, Heewon Lee, Magnus C. Eriksson, Steve Han, Peter Wipf, Guijun Wang, Keith R. Fandrick
Publikováno v:
Organic Letters. 15:1132-1135
The first uncatalyzed hydrophosphinations of propargylic amines and alcohols with phosphine- borane complexes are described. The reactions proceed at ambient temperature or below without the use of protecting groups or the need to handle pyrophoric s
Autor:
Diana C. Reeves, Nina C. Gonnella, Shengli Ma, Guisheng Li, Jonathan T. Reeves, Yibo Xu, Zhulin Tan, Heewon Lee, Yongda Zhang, Zhengxu S. Han, Bruce Z. Lu, Chris H. Senanayake
Publikováno v:
Angewandte Chemie. 124:1429-1433
Autor:
Xudong Wei, Jolaine Savoie, Bruce Z. Lu, Mckibben Bryan, Keith R. Fandrick, Heewon Lee, Jean-Nicolas Desrosiers, Melissa A. Herbage, Frank Roschangar, Zhibin Li, Donghong A. Gao, Chris H. Senanayake, Jonathan T. Reeves, Nina C. Gonnella, Maurice A. Marsini, C. Avery Sader, Jianwen Cui
Publikováno v:
Organic letters. 17(22)
A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to provide straightforward access to previously unobtainable, biologically relevant α-quaternar