Zobrazeno 1 - 7
of 7
pro vyhledávání: 'Tuček, Jan'
Autor:
Stanislav Tuček, Jan Jakubík
Publikováno v:
Scopus-Elsevier
We have found earlier that the neuromuscular blocker alcuronium binds to cardiac muscarinic receptors simultaneously with their specific antagonist [3H]methyl-N-scopolamine ([3H]NMS) and allosterically increases their affinity to this ligand. Nothing
Publikováno v:
Journal of Biological Chemistry. 275:18836-18844
After short preincubations with N-[(3)H]methylscopolamine ([(3)H]NMS) or R(-)-[(3)H]quinuclidinyl benzilate ([(3)H]QNB), radioligand dissociation from muscarinic M(1) receptors in Chinese hamster ovary cell membranes was fast, monoexponential, and in
Publikováno v:
British Journal of Pharmacology. 127:1240-1246
Seven esters of alpha-truxillic acid have been synthesized: bis-3-piperidylpropyl ester and its quaternary bis-N-ethyl derivative, bis-N-diethylaminopropyl ester and its quaternary bis-N-methyl derivative, and bis-4-piperidylbutyl ester and its quate
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 308(1)
Xanomeline is a novel agonist functionally selective for muscarinic receptors of the M 1 subtype. It binds to this receptor in two modes, reversible and quasi-irreversible (wash-resistant). We investigated the unknown mechanism of the wash-resistant
Autor:
Jan Proška, Stanislav Tuček
Publikováno v:
European journal of pharmacology. 305(1-3)
It was discovered recently that alcuronium and strychnine (which is a precursor of alcuronium) allosterically increase the affinity of cardiac muscarinic receptors for the antagonist, N-methylscopolamine. We have now investigated the effects of l-ebu
Autor:
Stanislav Tuček, Jan Jakubík
Publikováno v:
European journal of pharmacology. 289(2)
Changes in the allosteric effects of alcuronium on rat cardiac muscarinic receptors were investigated after chemical modifications of S-S bonds or free carboxyl groups. In membranes pretreated with dithiothreitol, alcuronium lost its positive action
Autor:
Jan Jakubík, Stanislav Tuček
1 By measuring the binding of N-[3H-methyl]-scopolamine ([3H]-NMS) and of unlabelled subtype-specific muscarinic antagonists, two populations of muscarinic binding sites can be distinguished in the membranes of cardiac ventricles taken from 1-day-old
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d2c72a2d01cb31fd244dd65b779fee
https://europepmc.org/articles/PMC1510540/
https://europepmc.org/articles/PMC1510540/