Zobrazeno 1 - 10
of 12 629
pro vyhledávání: '"selectivity"'
Publikováno v:
The Journal of Organic Chemistry. 87:2773-2778
Lewis-acid mediated allylations of β-alkoxy N-tosyl imines lead to 3-alkoxy homoallylic N-tosyl amines with anti diastereoselectivity. Diastereoselectivity and yields of reactions are comparable between two methods of Hosomi-Sakurai allylations. Obs
Publikováno v:
Organic Chemistry Frontiers. 9:129-139
A novel mechanism of the arylation of arenes via norbornene (NBE) relay palladation through meta- to para-selectivity was revealed via density functional theory (DFT) calculations. Our calculated results revealed that the reaction was initiated by a
Autor:
Shuqi Xing, Xuefeng Zeng, Ruonan Zhu, Yangyang Cai, Laping He, Kai Cheng, Cuiqin Li, Qifeng Zhang
Publikováno v:
Process Biochemistry. 111:118-127
The extracellular Aspergillus niger GZUF36 lipase (EXANL1) has broad applicability such as synthesis of functional lipids. The wild-type strain is unstable, and the culture time is long. Studies on the selectivity of substrates for EXANL1 are not ava
Autor:
Yulia Zonis, Dmitry Dar'in, Alexander Safrygin, Maxim Gureev, Mikhail Krasavin, Sergey Silonov, Mariia Kasatkina, Petr A. Zhmurov
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1916-1921 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
An earlier described three-component variant of the Castagnoli-Cushman reaction employing homophthalic anhydrides, carbonyl compound and ammonium acetate was applied towards the preparation of 1-oxo-3,4-dihydroisoquinoline-4-carboxamides with variabl
Publikováno v:
Synlett. 33:415-428
Silicon has been used in carbohydrate chemistry for half a century, but mostly as a protective group for sugar alcohols. Recently, the use of silicon has expanded to functionalization via C–H activation, conformational arming of glycosyl donors, an
Autor:
Xiaoguang Chen, Jing Jin, Ming Ji, Bailing Xu, Jie Zhou, Xiaoyu Wang, Ran Cao, Hailong Zhao, Li Sheng, Yan Li, Chen Xianhong
Publikováno v:
Journal of Medicinal Chemistry. 64:16711-16730
Inhibiting PARP-1/2 offered an important arsenal for cancer treatments via interfering with DNA repair of cancer cells. Novel PARP-1/2 inhibitors were designed by capitalizing on methyl- or ethyl-substituted piperizine ring to capture the characteris
Publikováno v:
Interdisciplinary Sciences: Computational Life Sciences. 14:233-244
d-amino acid introduction in peptides can enrich their biological activities and pharmacological properties as potential drugs. This achievement of stereochemical inversion usually owes to an epimerase or racemase. Interestingly, a unique bifunctiona
Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2 or D3 Receptor Agonists
Autor:
Francisco O. Battiti, Vsevolod Katritch, Saheem A. Zaidi, Amy Hauck Newman, Alessandro Bonifazi
Publikováno v:
Journal of Medicinal Chemistry. 64:16088-16105
Linkers are emerging as a key component in regulating the pharmacology of bitopic ligands directed toward G-protein coupled receptors (GPCRs). In this study, the role of regio- and stereochemistry in cyclic aliphatic linkers tethering well-characteri
Publikováno v:
Angewandte Chemie. 133:25601-25607
Low-temperature NMR studies with a 4-C-methyl-4-O-benzoyl galactopyranosyl donor enable the observation and characterization of a bridged bicyclic dioxacarbenium ion arising from participation by a distal ester. Variable-temperature NMR studies revea
Publikováno v:
Chemistry, Vol 3, Iss 86, Pp 1178-1188 (2021)
Chemistry
Volume 3
Issue 4
Pages 86-1188
Chemistry
Volume 3
Issue 4
Pages 86-1188
Several metal diimine complexes have been reported to possess anticancer properties. To evaluate the anticancer properties of tetrahedral zinc(II) diimine complexes, six complexes were synthesized with the general formula M(N^N)Cl2 {where M = Zn, Pt