Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Majer A"'
Autor:
Dan Su, Kyle M. Lancaster, Sean H. Majer, Rachael E. Coleman, Michael K. Fenwick, Brian R. Crane, Siddarth Chandrasekaran, Jack H. Freed, Boris Dzikovski, Hening Lin, Yugang Zhang
Publikováno v:
Journal of the American Chemical Society
All radical S-adenosylmethionine (radical-SAM) enzymes, including the noncanonical radical-SAM enzyme diphthamide biosynthetic enzyme Dph1–Dph2, require at least one [4Fe–4S](Cys)3 cluster for activity. It is well-known in the radical-SAM enzyme
Autor:
Martin Dračínský, Aleš Machara, Milan Kožíšek, Pavel Majer, Robert Reiberger, Jiří Brynda, Václav Zima, Kateřina Radilová, Michal Kráľ, Jan Konvalinka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7735, p 7735 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences
Volume 22
Issue 14
The part of the influenza polymerase PA subunit featuring endonuclease activity is a target for anti-influenza therapies, including the FDA-approved drug Xofluza. A general feature of endonuclease inhibitors is their ability to chelate Mg2+ or Mn2+ i
Publikováno v:
Chemical Science. 10:3756-3764
Ammonia oxidizing bacteria (AOB) use the cytotoxic, energetic molecule hydroxylamine (NH2OH) as a source of reducing equivalents for cellular respiration. Despite disproportionation or violent decomposition being typical outcomes of reactions of NH2O
Publikováno v:
IUCrData. 5
The title compound, ircinianin, C25H32O4, belongs to the sesterterpene tetronic acid compound family and was isolated from the marine sponge Ircinia wistarii. These chemical scaffolds are pharmacologically relevant, since they represent a new class o
Autor:
Jakub Majer, Łukasz Bojarski, Katarzyna Bazydlo, Filip Stefaniak, Maciej Wieczorek, Damian Smuga, Rafał Moszczyński-Pętkowski, Malgorzata Borkowska, Sylwia Janowska, Krzysztof Dubiel, Mikołaj Matłoka
Publikováno v:
European Journal of Medicinal Chemistry. 155:96-116
New compounds containing [1,2,4]triazolo [1,5-a]pyridine (I), pyrazolo [1,5-a]pyridine (II), 1H-1,3-benzodiazole (III) and imidazo [1,2-a]pyrimidine (IV) backbones were designed and synthesized for PDE10A interaction. Among these compounds, 1H-1,3-be
Autor:
Pavel Majer, Andrej Jančařík, Olga Bazalová, Jana Brabcová, Aleš Svatoš, Aleš Buček, Pavel Jedlička, Heiko Vogel, Robert Hanus, Anna Jirošová, Riya Christina Menezes, Klára Dolejšová
Publikováno v:
Insect Biochemistry and Molecular Biology. 82:52-61
The aliphatic nitroalkene ( E )-1-nitropentadec-1-ene ( NPD ), reported in early seventies in soldiers of the termite genus Prorhinotermes , was the first documented nitro compound produced by insects. Yet, its biosynthetic origin has long remained u
Autor:
Petr Pachl, Jana Pokorná, Ales Machara, Milan Kožíšek, Pavlína Řezáčová, Pavel Majer, Kateřina Rojíková, Václav Navrátil, Carlos Berenguer Albiñana, Jason Hudlicky, Jan Konvalinka, Václav Zima
Publikováno v:
Bioorganicmedicinal chemistry. 27(13)
This study focuses on design, synthesis and in vitro evaluation of inhibitory potency of two series of sialylmimetic that target an exosite ("150-cavity") adjacent to the active site of influenza neuraminidases from A/California/07/2009 (H1N1) pandem
Autor:
Rana Rais, Krystyna M. Wozniak, Niyada Hin, Zora Novakova, Takashi Tsukamoto, Jan Vávra, Camilo Rojas, Barbara S. Slusher, Andrej Jancarik, Jiri Pavlicek, Ying Wu, Pavel Majer, Dana Ferraris, Cyril Barinka, Barbora Havlinova, Jakub Ptacek
Publikováno v:
Journal of Medicinal Chemistry. 59:4539-4550
Inhibition of glutamate carboxypeptidase II (GCPII) is effective in preclinical models of neurological disorders associated with excessive activation of glutamatergic systems. Here we report synthesis, structural characterization, and biological acti
Publikováno v:
Croatica Chemica Acta, Vol 88, Iss 3, Pp 281-287 (2015)
Croatica Chemica Acta
Volume 88
Issue 3
Croatica Chemica Acta
Volume 88
Issue 3
Both the chemistry and consequences of the nonenzymatic reaction between reducing sugars and reactive amino groups of amino acids, peptides and proteins (known as the Maillard reaction), have received considerable attention in food and health science
Autor:
Szilvia Bősze, Sarolta Kárpáti, Katalin Uray, Hajnalka Szabados, Ferenc Hudecz, Zsuzsa Majer, Pálma Silló
Publikováno v:
Journal of Peptide Science. 21:731-742
Desmoglein-3 (Dsg3) adhesion protein is the main target of autoantibodies and autoreactive T cells in Pemphigus vulgaris (PV) autoimmune skin disorder. Several mapping studies of Dsg3 T cell epitope regions were performed, and based on those data, we