Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Ivonne M.C.M. Rietjens"'
Autor:
Ivonne M.C.M. Rietjens, Reiko Kiwamoto, Peter J. van Bladeren, Ala′ A.A. Al-Subeihi, Wasma Alhusainy, Bert Spenkelink, Ans Punt
Publikováno v:
Toxicology and Applied Pharmacology, 283(2), 117-126
Toxicology and Applied Pharmacology 283 (2015) 2
Toxicology and Applied Pharmacology 283 (2015) 2
The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1'-sulfooxymethyleugenol, in the human population by taking variability in key bioactivation and detoxification reactions into accou
Publikováno v:
Toxicological sciences 157 (2017) 2
Toxicological sciences, 157(2), 365-376
Toxicological Sciences, 2, 157, 365-376
Toxicological sciences, 157(2), 365-376
Toxicological Sciences, 2, 157, 365-376
With our recently developed in vitro physiologically based kinetic (PBK) modelling approach, we could extrapolate in vitro toxicity data to human toxicity values applying PBK-based reverse dosimetry. Ideally information on kinetic differences among h
Publikováno v:
Toxicology in Vitro, 44, 303-312
Toxicology in Vitro 44 (2017)
Toxicology in Vitro 44 (2017)
Prenatal developmental toxicity (PDT) as observed with some petroleum substances (PS) has been associated with the presence of 3–7 ring polycyclic aromatic hydrocarbons (PAHs). In the present study, the applicability of ES-D3 cell differentiation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b4c45bd3b600c67e142cd7d02a0bf6
https://research.wur.nl/en/publications/prenatal-developmental-toxicity-testing-of-petroleum-substances-a
https://research.wur.nl/en/publications/prenatal-developmental-toxicity-testing-of-petroleum-substances-a
Autor:
Stephen S. Hecht, Sean V. Taylor, Robert L. Smith, Maria Bastaki, Shoji Fukushima, Nigel J. Gooderham, Lawrence J. Marnett, C. G. Harman, Samuel M. Cohen, T. B. Adams, Ivonne M.C.M. Rietjens
Publikováno v:
Chemical Research in Toxicology, 27(7), 1092-1103
Chemical Research in Toxicology 27 (2014) 7
Chemical Research in Toxicology 27 (2014) 7
The metabolic fate of a compound is determined by numerous factors including its chemical structure. Although the metabolic options for a variety of functional groups are well understood and can often provide a rationale for the comparison of toxicit
Autor:
Ans Punt, A. Spenkelink, Peter J. van Bladeren, Ivonne M.C.M. Rietjens, Alicia Paini, Gabriele Scholz, Benoît Schilter
Publikováno v:
Chemical Research in Toxicology, 29(4), 659-668
Chemical Research in Toxicology 29 (2016) 4
Chemical Research in Toxicology 29 (2016) 4
Estragole is a known hepatocarcinogen in rodents at high doses following metabolic conversion to the DNA-reactive metabolite 1'-sulfooxyestragole. The aim of the present study was to model possible levels of DNA adduct formation in (individual) human
Autor:
Walter Brand, Denis Barron, Petronella A. I. van der Wel, Peter J. van Bladeren, Maarit Rein, Ivonne M.C.M. Rietjens, Gary Williamson
Publikováno v:
Drug Metabolism and Disposition 36 (2008) 9
Drug Metabolism and Disposition, 36(9), 1794-1802
Drug Metabolism and Disposition, 36(9), 1794-1802
Metabolism and transport from intestinal cells back into the lumen by ATP-binding cassette (ABC) transporters is believed to limit the bioavailability of flavonoids. We studied metabolism and transport of the citrus flavonoid hesperetin, the aglycone
Publikováno v:
Toxicology in Vitro 31 (2016)
Toxicology in Vitro, 31, 114-125
Toxicology in Vitro, 31, 114-125
Genotoxicity of α,β-unsaturated aldehydes shown in vitro raises a concern for the use of the aldehydes as food flavourings, while at low dose exposures the formation of DNA adducts may be prevented by detoxification. Unlike many α,β-unsaturated a
Publikováno v:
Toxicology and Applied Pharmacology 282 (2015) 1
Toxicology and Applied Pharmacology, 282(1), 108-117
Toxicology and Applied Pharmacology, 282(1), 108-117
Acyclic α,β-unsaturated aldehydes present in food raise a concern because the α,β-unsaturated aldehyde moiety is considered a structural alert for genotoxicity. However, controversy remains on whether in vivo at realistic dietary exposure DNA add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042079c17244f30cf465584f99dcafdb
https://research.wur.nl/en/publications/an-integrated-qsar-pbkd-modelling-approach-for-predicting-detoxif
https://research.wur.nl/en/publications/an-integrated-qsar-pbkd-modelling-approach-for-predicting-detoxif
Autor:
Hanem M. Awad, Ivonne M.C.M. Rietjens, Jacques Vervoort, Sjef Boeren, Marelle G. Boersma, Peter J. van Bladeren
Publikováno v:
Chemical Research in Toxicology 16 (2003) 7
Scopus-Elsevier
Chemical Research in Toxicology, 16(7), 822-831
Scopus-Elsevier
Chemical Research in Toxicology, 16(7), 822-831
Oxidation of flavonoids with a catechol structural motif in their B ring leads to formation of flavonoid quinone/quinone methides, which rapidly react with GSH to give reversible glutathionyl flavonoid adducts. Results of the present study demonstrat
Autor:
Ludmila A. Golovleva, Vassili V. M. Travkin, Willem J. H. van Berkel, Inna P. Solyanikova, J.J.M. Vervoort, Ivonne M.C.M. Rietjens
Publikováno v:
Journal of Environmental Science and Health. Part B, Pesticides Food Contaminants, and agricultural wastes 38 (2003)
Journal of Environmental Science and Health. Part B, Pesticides Food Contaminants, and agricultural wastes, 38, 121-132
Journal of Environmental Science and Health. Part B, Pesticides Food Contaminants, and agricultural wastes, 38, 121-132
3,4-Dichloro- and 3,4-difluoroanilines were degraded by Pseudomonas fluorescens 26-K under aerobic conditions. In the presence of glucose strain degraded 170 mg/L of 3,4-dichloroaniline (3,4-DCA) during 2-3 days. Increasing of toxicant concentration