Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Gerhard Schenk"'
Autor:
Luke W. Guddat, Ajit Kandale, Lendl Tan, Gerhard Schenk, Nicholas P. West, Shun Jie Wun, Waleed M. Hussein, Ross P. McGeary, Khushboo M. Patel, Shan Zheng
Publikováno v:
Journal of Medicinal Chemistry. 64:1670-1684
New drugs to treat tuberculosis (TB) are urgently needed to combat the increase in resistance observed among the current first-line and second-line treatments. Here, we propose ketol-acid reductoisomerase (KARI) as a target for anti-TB drug discovery
Autor:
Ross P. McGeary, Shun Jie Wun, Xin Lin, Gerhard Schenk, Julia L. Kurz, Nicholas P. West, Thierry G. A. Lonhienne, Luke W. Guddat, Waleed M. Hussein, Khushboo M. Patel
Publikováno v:
Chemistry – A European Journal. 27:3130-3141
New drugs aimed at novel targets are urgently needed to combat the increasing rate of drug resistant tuberculosis (TB). Here, the National Cancer Institute Developmental Therapeutic Program (NCI-DTP) chemical library was screened against a promising
Publikováno v:
ACS Catalysis. 10:3684-3696
In this DFT study, the substrate promiscuity of the binuclear [Fe(II)-Zn(II)] core containing glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes has been investigated through the hydrolysis of three chemically diverse groups of substrates: i
Autor:
Martina Haack, Marion Ringel, Wolfgang Eisenreich, Bernhard Loll, Thomas Brück, Daniel Garbe, Markus Reinbold, Russell G. Kerr, Mahmoud Masri, Gerhard Schenk, Luke W. Guddat, Max Hirte, Claudia Huber
Publikováno v:
Green Chemistry. 22:6033-6046
Pseudopterosins (Ps), marine diterpene glycosides derived from the marine octocoral Antillogorgia elisabethae, have potent anti-inflammatory activity demonstrated in phase II clinical trials. As multi-step total chemical synthesis is not economical,
Autor:
David W. Waite, Mikael Bodén, Gerhard Schenk, Luke W. Guddat, Liam A. Wilson, Christopher J. Schofield, Thomas Brück, Philip Hugenholtz, Marcelo Monteiro Pedroso, Marc T. Morris, Esmée Gianna Knaven
Publikováno v:
Antimicrob Agents Chemother
The structural diversity in metallo-β-lactamases (MBLs), especially in the vicinity of the active site, has been a major hurdle in the development of clinically effective inhibitors. Representatives from three variants of the B3 MBL subclass, contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fae9761592cef10df1f49e1b954ce8c
https://ora.ox.ac.uk/objects/uuid:cb4e0f1c-deee-448b-9047-afe7862e9e85
https://ora.ox.ac.uk/objects/uuid:cb4e0f1c-deee-448b-9047-afe7862e9e85
Autor:
Filipy Gobbo Maranha, Cláudia Donald Pereira, Nathalia Castilho, Giliandro Farias, Hernán Terenzi, Gerhard Schenk, Rosely A. Peralta, Bernardo de Souza, Ademir Neves
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 24:675-691
In this paper, the catalytic effects of aminoguanidine and aminopurine groups in the second sphere of a FeIIIZnII complex that mimics the active site of the metallohydrolase purple acid phosphatase (PAP) are investigated, with a particular view on DN
Autor:
Kemin Lv, Wenyu Shao, Jiayu Peng, Bin Wu, Gerhard Schenk, Jiahuang Li, Marcelo Monteiro Pedroso, Bingfang He
Publikováno v:
International journal of biological macromolecules. 168
Processive endoglucanases possess both endo- and exoglucanase activity, making them attractive discovery and engineering targets. Here, a processive endoglucanase EG5C-1 from Bacillus subtilis was employed as the starting point for enzyme engineering
Autor:
Rosely A. Peralta, Hernán Terenzi, Tiago Bortolotto, Ademir Neves, Adailton J. Bortoluzzi, Marcos Paulo da Silva, Cristine Saibert, Gerhard Schenk
Publikováno v:
Journal of inorganic biochemistry. 213
The research reported herein focuses on the synthesis of two new Cu(II) complexes {[Cu2(2-X-4,6-bis(di-2-picolylamino)-1,3,5-triazine], with X = butane-1,4-diamine (2) or N-methylpyrenylbutane-1,4-diamine (3)}, the latter with a pyrene group as a pos
Autor:
Daniel T.C. Tan, Marcelo Monteiro Pedroso, Hanna E. Sidjabat, Gerhard Schenk, Christopher Selleck, Ross P. McGeary
Publikováno v:
European Journal of Medicinal Chemistry. 137:351-364
A SAR study on derivatives of 2-amino-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile 5a revealed that the 3-carbonitrile group, vicinal 4,5-diphenyl and N-benzyl side chains of the pyrrole are important for the inhibitory potencies of these compound
Autor:
Nataša Mitić, Gerhard Schenk, David L. Ollis, Jeffrey Harmer, Marcelo Monteiro Pedroso, Luke W. Guddat, David L. Tierney, Waleed Helweh, Christopher Selleck, Whitney R. Craig, James A. Larrabee
Publikováno v:
Chemistry - A European Journal. 22:17704-17714
Antibiotic resistance has emerged as a major threat to global health care. This is largely due to the fact that many pathogens have developed strategies to acquire resistance to antibiotics. Metallo-β-lactamases (MBL) have evolved to inactivate most