Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Zhiyong Jiang"'
Publikováno v:
CCS Chemistry. 3:2192-2200
The stereoselective construction of vicinal all-carbon quaternary stereocenters has long been a formidable synthetic challenge. Direct asymmetric coupling of a tertiary carbon nucleophile with a te...
Autor:
Qiangqiang Zhan, Yunqiang Li, Xiaowei Zhao, Kuo-Wei Huang, Guanghui Wang, Baokun Qiao, Zhiyong Jiang, Yanli Yin, Théo P. Gonçalves
Publikováno v:
Journal of the American Chemical Society. 142:19451-19456
A radical-based asymmetric olefin difunctionalization strategy for rapidly forging all-carbon quaternary stereocenters α to diverse azaarenes is reported. Under cooperative photoredox and chiral Bronsted acid catalysis, cyclopropylamines with α-bra
Publikováno v:
Organic Chemistry Frontiers. 7:1343-1348
Herein, we report a chiral bifunctional thiourea catalyzed asymmetric Michael addition reaction between 2-(trifluoromethyl)oxazol-5(2H)-one as a direct C-2-position nucleophile and 4-nitro-5-styrylisoxazoles for the first time. The reaction affords t
Autor:
Manman Kong, Zhiyong Jiang, Choon-Hong Tan, Yaqi Tan, Baokun Qiao, Xiaowei Zhao, Shanshan Cao
Publikováno v:
Journal of the American Chemical Society. 143(10)
A novel enantioselective protonation protocol that is triggered by reductive cross coupling of olefins is reported. When under cooperative photoredox and chiral hydrogen-bonding catalytic conditions and using a terminal reductant, various α-branched
Autor:
Guobi Chai, Zhiyong Jiang, Xiaowei Zhao, Yajuan Li, Tianju Shao, Chunyang Li, Nana Ma, Baokun Qiao
Publikováno v:
iScience, Vol 16, Iss, Pp 410-419 (2019)
Summary: The site-specific incorporation of deuterium (D) into small molecules is frequently used to access isotopically labeled compounds with broad utility in many research areas, such as drug development, mechanistic studies, and NMR analyses. Nev
Publikováno v:
Synlett. 28:1310-1314
An unprecedented catalytic asymmetric reaction between azlactones and N-itaconimides has been developed. In the presence of an l-tert-leucine-based urea–tertiary amine Brønsted base catalyst, the tandem conjugate addition–protonation products co
Publikováno v:
Chemical Communications. 53:7493-7496
A direct strategy to construct chiral secondary C-O bonds for quaternary carbon stereocenters at the nonadjacent β-position is described. Methylene 1,3-oxazolidine-2,4-diones were for the first time employed in an asymmetric reaction as viable elect
Publikováno v:
Organic letters. 21(9)
An asymmetric, phase-transfer-catalyzed vinylogous conjugate addition-vinylogous cyclization cascade of olefinic azlactones with 4-nitro-5-styrylisoxazoles is reported. In the presence of an l- tert-leucine-derived urea-quaternary ammonium salt as a
Publikováno v:
Organic Chemistry Frontiers. 3:470-474
The first catalytic asymmetric conjugate addition of diaryloxazolidin-2,4-diones to nitroolefins is described. By employing an L-threonine-based tertiary amine-urea as the catalyst, the reaction proceeded in an excellent enantio- and diastereoselecti
Publikováno v:
Chemical Science. 7:6060-6067
Versatile synthetic strategies that access diverse chemical substrates in a highly chemo- and stereo-selective manner are crucial but demanding. Construction of chiral molecules with multiple (hetero)-quaternary carbon stereocenters in a single fashi