Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Jeremy N. Rich"'
Autor:
Ryan C. Gimple, Guoxin Zhang, Linjie Zhao, Leo J.Y. Kim, Jia Z. Shen, Cheryl Kim, Briana C. Prager, Xujun Wang, Jean A. Bernatchez, Xiang-Dong Fu, Jeremy N. Rich, Kailin Yang, Jair L. Siqueira-Neto, Deobrat Dixit, Zhixin Qiu, Lukas Chavez, Zhe Zhu, Deguan Lv, Ye Zheng, Denise Hinz, Zhengyu Liang, Charles Spruck, Xiuxing Wang, Chunyu Jin, Qiyuan Yang, Qiulian Wu, Lihua Min, Katherine A. Jones, Zhen Dong, Shruti Bhargava
Publikováno v:
Cancer Discov
Glioblastoma (GBM) is the most lethal primary brain cancer characterized by therapeutic resistance, which is promoted by GBM stem cells (GSC). Here, we interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-de
Autor:
Zhen Dong, Kristoffer Vitting-Seerup, Xiuxing Wang, Li Jiang, Qiulian Wu, Qi Xie, Briana C. Prager, Shruti Bhargava, Reilly L. Kidwell, Jeremy N. Rich, Zhixin Qiu, Leo J.Y. Kim, Deobrat Dixit, Yang Wang, Samie R. Jaffrey, Petra Hamerlik, Hui Xian Poh, Jing Crystal Zhao, Ryan C. Gimple, Zhe Zhu
Publikováno v:
Cancer Discov
Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here, we interrogated N6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA immunoprecipitation followed by sequencing and transcriptome analysis, findin
Autor:
Wenchao Zhou, Jeremy N. Rich, Kui Zhai, Shideng Bao, Weiwei Tao, Andrew E. Sloan, Jennifer S. Yu, Aili Zhang, Xiaoguang Fang, Zhi Huang
Publikováno v:
Neuro Oncol
Background The tumorigenic potential of glioma stem cells (GSCs) is associated with multiple reversible molecular alternations, but the role of posttranslational protein sumoylation in GSCs has not been elucidated. The development of GSC-targeting dr
Autor:
Jinkyu Jung, Amber J. Giles, Orieta Celiku, Wei Zhang, Brian J. Williams, Roger Abounader, Jeremy N. Rich, Mark R. Gilbert, Deric M. Park, Ying Zhang, Hua Song
Publikováno v:
Cancer Research. 79:5218-5232
Cancer cells rely on mitochondrial functions to regulate key survival and death signals. How cancer cells regulate mitochondrial autophagy (mitophagy) in the tumor microenvironment as well as utilize mitophagy as a survival signal is still not well u
Autor:
Stephen C. Mack, Leo J.Y. Kim, Hu Cang, Zhen Dong, Deguan Lv, Jeremy N. Rich, Megan E Wolf, Reilly L. Kidwell, Qi Xie, Tao Huan, Qing Ye, J. Mark Brown, Xiuxing Wang, Tengqian Sun, Junfeng Bi, Guoxin Zhang, Derrick Lee, Ryan C. Gimple, Andrew E. Sloan, Zhe Zhu, Shruti Bhargava, Anthony D. Gromovsky, Linjie Zhao, Briana C. Prager, Li Jiang, Qiulian Wu, Paul S. Mischel
Publikováno v:
Cancer Discovery. 9:1248-1267
Glioblastoma ranks among the most aggressive and lethal of all human cancers. Functionally defined glioma stem cells (GSC) contribute to this poor prognosis by driving therapeutic resistance and maintaining cellular heterogeneity. To understand the m
Autor:
Courtney L.R. Jurd, Kathleen S. Ensbey, Thomas Robertson, Zara C. Bruce, Paul R. Jamieson, Carolin Offenhäuser, Rochelle C.J. D’Souza, Bryan W. Day, Fiona M. Smith, Andrew W. Boyd, Po Inglis, Rosalind L. Jeffree, Kevin P. Campbell, Seckin Akgul, Yuchen Li, Justin D. Lathia, Zarnie Lwin, Yi Chieh Lim, Jeremy N. Rich, Terrance Grant Johns, Brett W. Stringer, Krishna P.L. Bhat, Ulrich Baumgartner
Publikováno v:
Acta Neuropathologica
Glioblastomas (GBMs) are malignant central nervous system (CNS) neoplasms with a very poor prognosis. They display cellular hierarchies containing self-renewing tumourigenic glioma stem cells (GSCs) in a complex heterogeneous microenvironment. One pr
Autor:
Shideng Bao, Kui Zhai, Xiaoguang Fang, Jeremy N. Rich, Zhi Huang, Leo J.Y. Kim, Jennifer S. Yu, Alexandru Almasan, Xiaoxia Li, Weiwei Tao, Qiulian Wu, Qian Huang, George R. Stark
Publikováno v:
Science Translational Medicine. 13
Glioblastoma (GBM), a lethal primary brain tumor, contains glioma stem cells (GSCs) that promote malignant progression and therapeutic resistance. SOX2 is a core transcription factor that maintains the properties of stem cells, including GSCs, but me
Autor:
Zhe Zhu, Arko Sen, Ryan C. Gimple, Donglim Esther Park, Jair L. Siqueira-Neto, Alex E. Clark, Sungjun Beck, Jean A. Bernatchez, Jeremy N. Rich, Graham McVicker, Briana C. Prager
Glioblastoma is the most prevalent primary malignant brain tumor in adults and is characterized by poor prognosis and universal tumor recurrence. Effective glioblastoma treatments are lacking, in part due to somatic mutations and epigenetic reprogram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b798adff051ed55d3ee8e042e514e418
https://doi.org/10.1101/2021.06.22.449493
https://doi.org/10.1101/2021.06.22.449493
Autor:
Weiwei Tao, Shideng Bao, Jeremy N. Rich, Justin D. Lathia, Jennifer S. Yu, Qiulian Wu, Xiaoguang Fang, Kui Zhai, Zhi Huang, Qian Huang
Glioblastoma (GBM) is the most lethal brain tumor containing glioma stem cells (GSCs) that promote malignant growth and therapeutic resistance. The self-renewal and tumorigenic potential of GSCs are maintained by core stem cell transcription factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68178abccb66485c9d847c6a1f27f98c
https://doi.org/10.1101/2021.06.09.447550
https://doi.org/10.1101/2021.06.09.447550
Autor:
H. Alex Brown, J. Mark Brown, Jeremy N. Rich, Justin D. Lathia, Luiz O. F. Penalva, Briana C. Prager, Arnon Møldrup Knudsen, Sajina Shakya, Christopher G. Hubert, Bjarne Winther Kristensen, Anthony D. Gromovsky, James S. Hale, Lisa C. Wallace
Publikováno v:
Shakya, S, Gromovsky, A D, Hale, J S, Knudsen, A M, Prager, B, Wallace, L C, Penalva, L O F, Brown, H A, Kristensen, B W, Rich, J N, Lathia, J D, Brown, J M & Hubert, C G 2021, ' Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches ', Acta Neuropathologica Communications, vol. 9, 101 . https://doi.org/10.1186/s40478-021-01205-7
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
BackgroundGlioblastoma (GBM) is marked by cellular heterogeneity, including metabolic heterogeneity, that varies among cellular microenvironments in the same tumor. Altered cellular metabolism in cancer is well-established, but how lipid metabolism i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f771c8bce9d113f49f80845ee84e7a6e
https://findresearcher.sdu.dk:8443/ws/files/183278150/s40478_021_01205_7.pdf
https://findresearcher.sdu.dk:8443/ws/files/183278150/s40478_021_01205_7.pdf