Zobrazeno 31 - 40
of 157
pro vyhledávání: '"Jeremy N. Rich"'
Autor:
Cong Chen, Sen-Lin Xu, Jeremy N. Rich, Yi-Fang Ping, Zhi-Cheng He, Yu Shi, Xiaoguang Fang, Lin Cheng, Justin D. Lathia, Zhi Huang, Qiulian Wu, Shideng Bao, Xiu-Wu Bian, Wenchao Zhou
Publikováno v:
Cell Death & Differentiation. 24:167-180
Glioblastoma (GBM) is the most malignant and lethal brain tumor harboring glioma stem cells (GSCs) that promote tumor propagation and therapeutic resistance. GSCs preferentially express several critical cell surface molecules that regulate the pro-su
Autor:
Zhe Zhu, Ryan C. Gimple, Shideng Bao, Shruti Bhargava, Xiqing Li, Jeremy N. Rich, Guoxing Zhang, Leo J.Y. Kim, Stephen C. Mack, Linjie Zhao, Zhixin Qiu, Xiuxing Wang, Briana C. Prager, Paul S. Mischel, Sameer Agnihotri, Yu Shi, Li Jiang, Qiulian Wu, Kailin Yang, Andrew R. Morton, Wenchao Zhou, Weiwei Tao
Publikováno v:
Sci Transl Med
Glioblastoma stem cells (GSCs) reprogram glucose metabolism by hijacking high-affinity glucose uptake to survive in a nutritionally dynamic microenvironment. Here, we trace metabolic aberrations in GSCs to link core genetic mutations in glioblastoma
Autor:
Xiuxing Wang, Guoxin Zhang, Leo J.K. Kim, Petra Hamerlik, Briana C. Prager, Ryan C. Gimple, Zhen Dong, Jeremy N. Rich, Shideng Bao, Qiulian Wu
Publikováno v:
JCI Insight. 4
Glioblastomas, which contain stem cell-like glioblastoma stem cells (GSCs), are universally lethal cancers. While neural stem cells (NSCs) are usually quiescent, single-cell studies suggest that proliferating glioblastoma cells reside in the GSC popu
Autor:
Guoxin Zhang, Haidong Huang, Ryan C. Gimple, Zhixin Qiu, Stephen C. Mack, Shideng Bao, Zhen Dong, Leo J.Y. Kim, Lukas Chavez, Deobrat Dixit, Bin Li, Briana C. Prager, Andrew R. Morton, Xiuxing Wang, Zhe Zhu, Meng Qu, Steve A. Kay, Jeremy N. Rich, Wenchao Zhou, Qiulian Wu
Publikováno v:
Cancer Discov
Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSC). Here, we show that GSCs, differentiated glioblastoma cells (DGC), and nonmalignant brain cultures all displayed robust circadian rhythms, yet GSCs alone
Autor:
Xiuxing Wang, Wenchao Zhou, Lukas Chavez, Shideng Bao, Andrew E Sloan, Michael A. Vogelbaum, Jean A. Bernatchez, Kelsey C. Bertrand, Peter C. Scacheri, Q Wu, Irtisha Singh, Clarence K. Mah, Stephen C. Mack, Jair L. Siqueira-Neto, Zhixin Qiu, Andrew R. Morton, Rosie Villagomez, Sisi Lai, Gene H. Barnett, Christine Lee, Rachel A. Hirsch, Briana C. Prager, Jeremy N. Rich, Zhe Zhu, Ryan C. Gimple, Charles Y. Lin, Leo J.Y. Kim
Publikováno v:
The Journal of Experimental Medicine
Mack et al. defined active chromatin landscapes of glioblastoma stem cells (GSCs) and primary tumor specimens, revealing novel transcriptional regulatory circuits and therapeutic targets. Super-enhancers identified essential transcription factors tha
Autor:
Xiaoguang Fang, Zhi Huang, Cheng wei Chu, Shideng Bao, Yu Shi, Jeremy N. Rich, Lin Cheng, Qi Xie, Xiu-Wu Bian, Susan Q. Ke, Wenchao Zhou
Publikováno v:
Oncotarget
Glioblastoma multiforme (GBM) is the most lethal brain tumor. Tumor relapse in GBM is inevitable despite maximal therapeutic interventions. Glioma stem cells (GSCs) have been found to be critical players in therapeutic resistance and tumor recurrence
Publikováno v:
Cancer Research. 80:6611-6611
Glioblastoma is the most prevalent and aggressive primary brain tumor in adults, and conventional treatment strategies have made minimal progress in prolonging overall survival. Cancer stem cells are critical for tumor initiation, growth, and mainten
Autor:
Bjarne Winther Kristensen, Justin D. Lathia, Arnon Møldrup Knudsen, James S. Hale, J. Mark Brown, Andrew E Sloan, Briana C. Prager, Jeremy N. Rich, Lisa C. Wallace, Christopher G. Hubert, Daniel J. Silver, Anthony D. Gromovsky
Publikováno v:
Neuro Oncol
Clinical glioblastoma is marked by a strikingly heterogeneous mix of cell types, cellular metabolisms, and cellular microenvironments spread in different spatial locations throughout a tumor. We have created 3-dimensional organoid models that partial
Autor:
Stephen C. Mack, Ryan C. Gimple, Shideng Bao, Andrew R. Morton, Guoxing Zhang, Linjie Zhao, Sameer Agnihotri, Xiuxing Wang, Wenchao Zhou, Leo J.Y. Kim, Weiwei Tao, Briana C. Prager, Yu Shi, Kailin Yang, Xiqing Li, Jeremy N. Rich, Li Jiang, Qiulian Wu, Paul S. Mischel, Zhixin Qiu, Shruti Bhargava, Zhe Zhu
Publikováno v:
Neuro Oncol
Glioblastoma stem cells (GSCs) reprogram glucose metabolism by hijacking high-affinity glucose uptake to survive in a nutritionally dynamic microenvironment. Here, we trace metabolic aberrations in GSCs to link core genetic mutations in glioblastoma
Autor:
Sungjun Beck, Cleber A. Trujillo, Alysson R. Muotri, Priscilla D. Negraes, Zhou Lan, Rekha Dhanwani, Michael S. Diamond, Zhe Zhu, Qiulian Wu, Simon T. Schafer, Stephen C. Mack, Ryan C. Gimple, Sara M. Weis, Jair L. Siqueira-Neto, Jeremy N. Rich, Sanjay Dhawan, Briana C. Prager, Fred H. Gage, Sonia Sharma, Robert J. Wechsler-Reya, Alex W. Wessel, Leo J.Y. Kim, Hiromi I. Wettersten, Clark C. Chen, Pinar Mesci, Alex E. Clark, Jean A. Bernatchez, Rong Zhang, Xiuxing Wang, David A. Cheresh, Luiz O. F. Penalva, Jing Feng, Hongzhen Hu, Alexandra Garancher
Publikováno v:
Cell Stem Cell
Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem cells (GSCs). Here we demonstrate that ZIKV preferentially infecte