Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Harley I. Kornblum"'
Autor:
Kruttika Bhat, Ling He, Harley I. Kornblum, Nhan T. Nguyen, Paul Medina, Mohammad Saki, Angeliki Ioannidis, David Sung, Linda M. Liau, Le Zhang, Clara E. Magyar, Sirajbir S. Sodhi, Frank Pajonk
Publikováno v:
Neuro-oncology, vol 22, iss 10
Neuro Oncol
Neuro Oncol
BackgroundNormal tissue toxicity to the CNS is an inevitable consequence of a successful radiotherapy of brain tumors or cancer metastases to the CNS. Cranial irradiation commonly leads to neurocognitive deficits that manifest months or years after t
Autor:
Yasmin Ghochani, Sree Deepthi Muthukrishnan, Alireza Sohrabi, Riki Kawaguchi, Michael C. Condro, Soniya Bastola, Fuying Gao, Yue Qin, Jack Mottahedeh, M. Luisa Iruela-Arispe, Nagesh Rao, Dan R. Laks, Linda M. Liau, Gary W. Mathern, Steven A. Goldman, S. Thomas Carmichael, Ichiro Nakano, Giovanni Coppola, Stephanie K. Seidlits, Harley I. Kornblum
Publikováno v:
Ghochani, Y, Muthukrishnan, S D, Sohrabi, A, Kawaguchi, R, Condro, M C, Bastola, S, Gao, F, Qin, Y, Mottahedeh, J, Iruela-Arispe, M L, Rao, N, Laks, D R, Liau, L M, Mathern, G W, Goldman, S A, Carmichael, S T, Nakano, I, Coppola, G, Seidlits, S K & Kornblum, H I 2022, ' A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration ', Cell Reports, vol. 41, no. 3, 111511 . https://doi.org/10.1016/j.celrep.2022.111511
Cell reports, vol 41, iss 3
Cell reports, vol 41, iss 3
Glioblastoma (GBM) is characterized by extensive microvascular hyperproliferation. In addition to supplying blood to the tumor, GBM vessels also provide trophic support to glioma cells and serve as conduits for migration into the surrounding brain, p
Autor:
Michael C. Condro, Raymond Gau, Nathan VanderVeer-Harris, Q. Wang, Amy Pham, Yue Qin, Steven A. Goldman, Alvaro G. Alvarado, Maverick Johnson, Pooja Nair, Pedro R. Lowenstein, Rachna Prasad, Sree Deepthi Muthukrishnan, Arjun Deb, Maria G. Castro, Jason D Hinman, Daniel H. Geschwind, Riki Kawaguchi, Terry C. Burns, Frank Pajonk, Harley I. Kornblum
Treatment-refractory glioma stem and tumor cells exhibit phenotypic plasticity driving recurrence, but the underlying molecular mechanisms remain to be elucidated. Here, we employed single-cell and whole transcriptomic analyses to discover that radia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e3d98d4529be4b2c07217d687e34026
https://doi.org/10.1101/2021.06.03.447005
https://doi.org/10.1101/2021.06.03.447005
Autor:
Phioanh L. Nghiemphu, Harley I. Kornblum, Angeliki Ioannidis, Le Zhang, Kruttika Bhat, Joshua E. Allen, Nhan T. Nguyen, Timothy F. Cloughesy, Ling He, Linda M. Liau, Frank Pajonk
Publikováno v:
Radiother Oncol
Background Glioblastoma (GBM) is the deadliest of all brain cancers in adults. The current standard-of-care is surgery followed by radiotherapy and temozolomide, leading to a median survival time of only 15 months. GBM are organized hierarchically wi
Autor:
Linda M. Liau, Le Zhang, Frank Pajonk, Kruttika Bhat, Angeliki Ioannidis, Timothy F. Cloughesy, Jashua E Allen, Ling He, Phioanh L. Nghiemphu, Harley I. Kornblum, Nhan T. Nguyen
BackgroundGlioblastoma (GBM) is the deadliest of all brain cancers in adults. The current standard-of-care is surgery followed by radiotherapy and temozolomide, leading to a median survival time of only 15 months. GBM are organized hierarchically wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::352e8228dab06a304a035c16794d34f8
https://doi.org/10.1101/2020.07.23.218446
https://doi.org/10.1101/2020.07.23.218446
Autor:
Harley I. Kornblum, Kirsten Ludwig, Maeve A. Caldwell, Janel E. Le Belle, Neil G. Harris, Jantzen Sperry
Fatty acids are well known as important constituents for the synthesis of membrane lipids and as sources of cellular energy in the CNS. However, fatty acids can also act as vital second messenger molecules in the nervous system and regulate the activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a6ab7a9c575ecf9d424a6128552c2c
https://doi.org/10.1101/2020.02.10.942870
https://doi.org/10.1101/2020.02.10.942870
Autor:
Harley I. Kornblum, Sadashib Ghosh, Ichiro Nakano, Soniya Bastola, Marat S. Pavlyukov, Morgan Kurowsky, Yasmin Ghochani
Publikováno v:
Neuro Oncol
BACKGROUND Glioblastoma (GBM) is a highly invasive, angiogenic and therapeutically resistant primary brain tumor. It is impossible to completely resect the tumor, which subsequently leaves behind tumor “edge” that can act as seeds for recurrence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b039b019d092e9c74a2a8ba339a5f577
https://europepmc.org/articles/PMC6846403/
https://europepmc.org/articles/PMC6846403/
Autor:
Harley I. Kornblum, Maverick Johnson, Kaleab Tessema, Michael C. Condro, Sree Deepthi Muthukrishnan
Glioblastoma (GBM) is a highly vascularized, invasive and therapy-resistant brain tumor driven by glioma stem-like cells (GSCs). GSCs reside in three specialized niches or microenvironments: the perivascular, hypoxic and invasive niches. The perivasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b2f6710d43c2d942d6915033f98192
https://europepmc.org/articles/PMC6217109/
https://europepmc.org/articles/PMC6217109/
Publikováno v:
Cell stem cell, vol 22, iss 4
Cell Stem Cell
Cell Stem Cell
Glioblastoma is the most lethal primary brain tumor, however the crosstalk between glioblastoma stem cells (GSCs) and their supportive niche is not well understood. Here, we interrogated reciprocal signaling between GSCs and their differentiated glio
Autor:
Harley I. Kornblum, J.E. Le Belle
Publikováno v:
Neuron. 101:1-2
Microenvironment cues and cell-to-cell interactions balance stem cell quiescence with proliferation and direct neurogenesis in the adult hippocampal niche. Tang et al. report that hippocampal stem cells release feedback signals that regulate the dend