Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Manal F. Abdelmalek"'
Autor:
Cynthia A. Moylan, Alisha M. Mavis, Dereje Jima, Rachel Maguire, Mustafa Bashir, Jeongeun Hyun, Melanie N. Cabezas, Alice Parish, Donna Niedzwiecki, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, Cathrine Hoyo
Publikováno v:
Epigenetics, Vol 17, Iss 11, Pp 1446-1461 (2022)
Non-Alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. Epigenetic alterations, such as through DNA methylation (DNAm), may link adverse childhood exposures and fatty liver and provide non-invasive methods
Externí odkaz:
https://doaj.org/article/340dddde15ac419da0f5f9f960cb993c
Autor:
Rajanshu Verma, Naga Swetha Samji, Mary E. Rinella, Ashwani K. Singal, Aijaz Ahmed, Krishna C. Keri, David I. Bernstein, Manal F. Abdelmalek, Sanjaya K. Satapathy
Publikováno v:
Digestive Diseases and Sciences. 64:3413-3430
Nonalcoholic steatohepatitis is the fastest-growing indication for the liver transplant and a leading cause of hepatocellular carcinoma among patients listed for liver transplantation in the USA. Post-transplant nonalcoholic hepatic steatosis and ste
Autor:
Manal F. Abdelmalek, Margery A. Connelly, Stephen J. Rossi, Mary E. Rinella, Angelo H. Paredes, Stephen A. Harrison, Lei Ling, James F. Trotter, Mark J. Jaros, Alex M. DePaoli
Publikováno v:
Journal of Hepatology. 70:735-744
NGM282, an engineered analogue of the gut hormone FGF19, improves hepatic steatosis and fibrosis biomarkers in patients with non-alcoholic steatohepatitis (NASH). However, NGM282 increases serum cholesterol levels by inhibiting CYP7A1, which encodes
Autor:
Wing-Kin Syn, Keyur Patel, Cynthia D. Guy, Anna Mae Diehl, Robert D. Streilein, Ricardo Henao, Oliver Glass, Hans J Gruss, Manal F. Abdelmalek, Cynthia A. Moylan, Russell P. Hall
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
The severity of hepatic fibrosis is the primary predictor of liver‐related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD‐associated fibrosis are limited. W
Autor:
Naim Alkhouri, Andrea D. Coviello, Manal F. Abdelmalek, Eduardo B. Martins, Gerardo Rodriguez
Publikováno v:
Diabetes. 69
Introduction: In mice, C-C motif chemokine receptor (CCR)5 deletion protects against insulin resistance, hepatic steatosis, and glucose intolerance. We aimed to characterize the metabolic effects of cenicriviroc (CVC), a potent CCR2/5 inhibitor, in t
Autor:
Kris V. Kowdley, Mark L. Van Natta, Arun J. Sanyal, James Tonascia, Edward Doo, Raj Vuppalanchi, Mohammad S. Siddiqui, David E. Kleiner, Manal F. Abdelmalek, Rohit Loomba, Danielle Brandman, Erin Hallinan, Brent A. Neuschwander-Tetri, Srinivas Dasarathy, Naga Chalasani
Publikováno v:
Hepatology. 67:134-144
Vibration-controlled transient elastography estimates liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), which are noninvasive assessments of hepatic fibrosis and steatosis, respectively. However, prior vibration-controlled
Autor:
Ransi M. Somaratne, Stephen J. Rossi, Stephen A. Harrison, Mark Jaros, Manal F. Abdelmalek, Lei Ling, Alex M. DePaoli
Publikováno v:
Diabetes. 67
Background: NGM282 is an engineered variant of human FGF-19 that retains bile acid and metabolic regulatory activities while eliminating the tumorigenic effects of FGF-19. Multiple preclinical models showed improvements in NASH liver histology simila
Autor:
Zac Anchi Chang, Claude B. Sirlin, Benjamin Wildman-Tobriner, Stephen J. Rossi, Manal F. Abdelmalek, Mustafa R. Bashir, Cynthia A. Moylan, Michael M. Middleton, Omar Flores
Publikováno v:
Gastroenterology. 155(5)
BACKGROUND & AIMS: Patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) often require histologic assessment via liver biopsy. Magnetic resonance imaging (MRI)-based methods for measuring liver triglycerides ba
Autor:
Mark L. Palmeri, Manal F. Abdelmalek, Kathryn R. Nightingale, Michael H. Wang, Cynthia D. Guy, Ned C. Rouze, Stephen J. Rosenzweig
Publikováno v:
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 62:165-175
Commercially-available shear wave imaging systems measure group shear wave speed (SWS) and often report stiffness parameters applying purely elastic material models. Soft tissues, however, are viscoelastic, and higher-order material models are necess
Autor:
Danielle Brandman, Erin Hallinan, Brent A. Neuschwander-Tetri, Srinivasan Dasarathy, Raj Vuppalanchi, Naga Chalasani, David E. Kleiner, Kris V. Kowdley, Manal F. Abdelmalek, Rohit Loomba, Arun J. Sanyal, Edward Doo, James Tonascia, Mohammad S. Siddiqui, Mark L. Van Natta
Publikováno v:
Clinical Gastroenterology and Hepatology. 17:156-163.e2
Background & Aims Vibration-controlled transient elastography (VCTE), which measures liver stiffness, has become an important tool for evaluating patients with nonalcoholic fatty liver disease (NAFLD). We aimed to determine the diagnostic accuracy of