Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Franz Koenig"'
Publikováno v:
Statistical Methods in Medical Research. 31:2470-2485
When testing multiple hypotheses, a suitable error rate should be controlled even in exploratory trials. Conventional methods to control the False Discovery Rate (FDR) assume that all p-values are available at the time point of test decision. In plat
Publikováno v:
Biostatistics.
Summary For randomized clinical trials where a single, primary, binary endpoint would require unfeasibly large sample sizes, composite endpoints (CEs) are widely chosen as the primary endpoint. Despite being commonly used, CEs entail challenges in de
Autor:
Peter K. Kimani, Martin Posch, Werner Brannath, Lisa V. Hampson, James Wason, Johannes Krisam, Thomas Jaki, S. Faye Williamson, Nigel Stallard, Sarah Zohar, Thomas Burnett, John Whitehead, Norbert Benda, Pavel Mozgunov, Franz Koenig, Gernot Wassmer, Tim Friede
Publikováno v:
Statistics in Biopharmaceutical Research
Statistics in Biopharmaceutical Research, 2020, 12 (4), pp.483-497. ⟨10.1080/19466315.2020.1790415⟩
article-version (VoR) Version of Record
Statistics in Biopharmaceutical Research, 2020, 12 (4), pp.483-497. ⟨10.1080/19466315.2020.1790415⟩
article-version (VoR) Version of Record
The COVID-19 pandemic has led to an unprecedented response in terms of clinical research activity. An important part of this research has been focused on randomized controlled clinical trials to evaluate potential therapies for COVID-19. The results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9e91dcef704c907a1dfc0389c3ff5a
https://hal.archives-ouvertes.fr/hal-03122983
https://hal.archives-ouvertes.fr/hal-03122983
Publikováno v:
Statistics in Medicine. 37:4335-4352
Population heterogeneity is frequently observed among patients' treatment responses in clinical trials because of various factors such as clinical background, environmental, and genetic factors. Different subpopulations defined by those baseline fact
Publikováno v:
Statistics in Medicine. 37:3387-3402
Adaptive enrichment designs have recently received considerable attention as they have the potential to make drug development process for personalized medicine more efficient. Several statistical approaches have been proposed so far in the literature
Publikováno v:
Statistical methods in medical research. 29(6)
In rare diseases, fully powered large trials may not be doable in a reasonable time frame even with international collaborations. In a previous work, we proposed an approach based on a series of smaller parallel group two-arm randomised controlled tr
Autor:
Thomas Jaki, Allan Gordon, Pamela Forster, Luc Bijnens, Bjoern Bornkamp, Werner Brannath, Roberto Fontana, Mauro Gasparini, Lisa V. Hampson, Tom Jacobs, Byron Jones, Xavier Paoletti, Martin Posch, Andrew Titman, Richardus Vonk, Franz Koenig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd4bc10bac78ce30f87f5533370374d
https://doi.org/10.1002/pst.1942
https://doi.org/10.1002/pst.1942
Publikováno v:
Biometrical Journal. Biometrische Zeitschrift
If the response to treatment depends on genetic biomarkers, it is important to identify predictive biomarkers that define (sub-)populations where the treatment has a positive benefit risk balance. One approach to determine relevant subpopulations are
Publikováno v:
Pharmaceutical statistics
Multiple testing procedures defined by directed, weighted graphs have recently been proposed as an intuitive visual tool for constructing multiple testing strategies that reflect the often complex contextual relations between hypotheses in clinical t
Publikováno v:
Statistics in Medicine. 28:1181-1217
Adaptive designs play an increasingly important role in clinical drug development. Such designs use accumulating data of an ongoing trial to decide how to modify design aspects without undermining the validity and integrity of the trial. Adaptive des