Zobrazeno 1 - 10
of 29
pro vyhledávání: '"David G. Hoel"'
Autor:
David G. Hoel, Mulugeta Gebregziabher
Publikováno v:
Human and Ecological Risk Assessment: An International Journal. 15:858-875
The statistical analysis of cancer bioassay data has historically depended on the pathological determination of the experimental animal's cause of death. The poly-k statistical test has provided a method of statistical analysis of animal bioassay dat
Publikováno v:
Clinical Chemistry. 55:165-169
Background: Laboratory studies often involve analyses of highly skewed data for which means are not an adequate measure of central tendency because they are sensitive to outliers. Attempts to transform skewed data to symmetry are not always successfu
Autor:
Richard Wakeford, Colin R. Muirhead, David G. Hoel, J. Molitor, John D. Boice, Mark P. Little
Publikováno v:
Radiation Research. 169:660-676
Generalized relative and absolute risk models are fitted to the latest Japanese atomic bomb survivor solid cancer and leukemia mortality data (through 2000), with the latest (DS02) dosimetry, by classical (regression calibration) and Bayesian techniq
Publikováno v:
Risk Analysis. 12:115-121
The use of average qualitative concordance between two bioassay endpoints is considered, with emphasis directed at agreement between rats and mice from results of long-term carcinogenicity studies. It is noted that concordance varies as a function of
Autor:
Gizelle S. Baker, David G. Hoel
Publikováno v:
Health physics. 85(6)
Cancer incidence and mortality data from the cohort of Japanese atomic bomb survivors in Hiroshima have been adjusted for the uncertainty that exists in the dose estimates, the systematic error in the neutron dose estimates, and a dose-dependent rela
Autor:
Tomas Radivoyevitch, David G. Hoel
Publikováno v:
Radiation and environmental biophysics. 39(3)
Radiation cancer risks are typically deter- mined by the use of simple statistical descriptions of epidemiological data. It is important in risk assessment in general, however, to attempt to incorporate as much biological information into the risk mo
Autor:
David G. Hoel, Gerald R. Chase
Publikováno v:
Biometrika. 62:329-334
SUMMARY The effect of small errors of dilution is shown to be sizeable when serial dilutions are required to estimate particle concentrations. Optimal dilution designs are given. The error effect and optimal design are also investigated for ratios of
Publikováno v:
Biometrika. 62:195-200
We examine results produced by a new likelihood stopping rule for terminating clinical trials, designed to choose the better of two competing dichotomous treatments, or to decide that they are equal. A method for adaptive assignment is also discussed
Autor:
Takashi Yanagawa, David G. Hoel
Publikováno v:
Environmental Health Perspectives
Statistical methods for the use of historical control data in testing for a trend in proportions in carcinogenicity rodent bioassays are reviewed. Asymptotic properties of the Hoel-Yanagawa exact conditional tests are developed and compared with the
Autor:
Christopher J. Portier, David G. Hoel
Publikováno v:
Risk Analysis. 7:437-447
The TD50 (or tumorigenic dose rate 50) is a generally accepted measure of the carcinogenic potency of a chemical in a particular strain of animal. This paper discusses error in the estimation of the TD50 caused by intercurrent mortality and error res