Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Chenglong LI"'
Autor:
Li Pan, Jonathan L. Finlay, Ruijie Zhang, Ling Ma, Jiayuh Lin, Christopher R. Pierson, Chenglong Li
Publikováno v:
Cancer Biol Ther
Persistent activation of signal transducer and activator of transcription 3 (STAT3) is frequently reported in cancers and plays important roles in tumor progression. Therefore, directly targeting persistent STAT3 signaling is an attractive cancer the
Autor:
Shengling Fu, Ruijie Zhang, Jiayuh Lin, Jinhua Song, Jia Wei, Li Pan, Jonathan L. Finlay, Chenglong Li, Xiang Chen, Christopher R. Pierson, Ren Yuan Bai, Xiaozhi Yang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor and an oncogene product, which plays a pivotal role in tumor progression. Therefore, targeting persistent STAT3 signaling directly is an attractive anticancer strate
Autor:
Tianshu Liu, Wei Shi, Sheng Li, Maocai Zhai, Shengqi Huo, Junyi Guo, Cuntai Zhang, Li Lin, Jiayuh Lin, Haiyan Ma, Chenglong Li, Pengcheng Luo, Dan Yan, Jiagao Lv, Jingwen Tao
Publikováno v:
Journal of Cellular and Molecular Medicine
The role of IL‐6 signalling in hypertensive heart disease and its sequelae is controversial. Our group demonstrated that Bazedoxifene suppressed IL‐6/gp130 signalling in cancer cells but its effect on myocardial pathology induced by pressure over
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0240145 (2021)
PLoS ONE, Vol 16, Iss 4, p e0240145 (2021)
Ovarian cancer is the fifth most common cause of cancer deaths among American women. Platinum and taxane combination chemotherapy represents the first-line approach for ovarian cancer, but treatment success is often limited by chemoresistance. Theref
Publikováno v:
Current Cancer Drug Targets. 19:571-582
Background:Medulloblastoma is the most common malignant brain tumor in children. Despite improvement in overall survival rate, it still lacks an effective targeted treatment strategy. The Janus family of cytoplasmic tyrosine kinases (JAKs) and Src ki
Autor:
Wei Pei, Emma E Kraus, Xiaozhi Yang, Michael K. Racke, Marissa F. Farinas, Saba I. Aqel, Amy E. Lovett-Racke, Jinhua Song, Erin Y Zhao, Yuhong Yang, Chenglong Li
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 4 (2021)
JCI Insight, Vol 6, Iss 4 (2021)
Reestablishing an appropriate balance between T effector cells (Teff) and Tregs is essential for correcting autoimmunity. Multiple sclerosis (MS) is an immune-mediated chronic CNS disease characterized by neuroinflammation, demyelination, and neurona
Autor:
Li Lin, Pengcheng Luo, Wei Shi, Shengqi Huo, Dan Yan, Chenglong Li, Sheng Li, Jiayuh Lin, Junyi Guo, Haiyan Ma, Jiagao Lv, Cuntai Zhang
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Background. Inflammation and oxidative stress are involved in the initiation and progress of heart failure (HF). However, the role of the IL6/STAT3 pathway in the pressure overload-induced HF remains controversial. Methods and Results. Transverse aor
Autor:
Shengqi Huo, Tianshu Liu, Haiyan Ma, Jiayuh Lin, Cuntai Zhang, Wei Shi, Junyi Guo, Moran Wang, Chenglong Li, Jiagao Lv, Pengcheng Luo, Yina Wang, Sheng Li, Dan Yan, Li Lin
Publikováno v:
Life sciences. 261
Aims The signal transducer and activator of transcription 3 (STAT3) pathway plays an important role in inflammatory cascade process. Our previous studies found that Raloxifene targeted against IL-6/GP130 protein-protein interface and inhibited STAT3
Autor:
Chengguang, Zhao, Lehe, Yang, Feng, Zhou, Yun, Yu, Xiaojing, Du, Youqun, Xiang, Chenglong, Li, Xiaoying, Huang, Congying, Xie, Zhiguo, Liu, Jiayuh, Lin, Liangxing, Wang, Guang, Liang, Ri, Cui
Publikováno v:
Oncogene. 39(20)
Pancreatic cancer is one of the world's leading causes of cancer-related death. Activation of STAT3 has been reported as a major contributor in pancreatic cancer tumorigenesis and chemoresistance. However, treatment of advanced pancreatic cancer pati
Autor:
Li, Pan, Xiang, Chen, Shengling, Fu, Wenying, Yu, Chenglong, Li, Tiffany, Wang, Hui-Wen, Lo, Jiayuh, Lin
Publikováno v:
Breast cancer research and treatment. 181(1)
Persistent STAT3 signaling is frequently detected in many cancer types including triple-negative breast cancer, and thus could potentially serve as a viable therapeutic target. We have designed a novel non-peptide compound LLY17 targeting STAT3 using